Allele frequency distribution of CYP2C9*2 and CYP2C9*3 polymorphisms in six Mexican populations

Genotype frequencies of VKORC1 and CYP2C9 in Native and Mestizo populations from Mexico, potential impact for coumarin dosing

“…Similar to previous reports, this indicates a prevalent phenotype (≥ 92%) of CYP2C9 extensive metabolizers among these four native populations (Castelan-Martinez et al, 2013). Homozygous alleles for CYP2C9 nonfunctional alleles, *2, *3, *4, and *5, were absent in natives, and only 3% were heterozygous for a variant allele (Table 1).…”

“…In support, frequency differences among populations indicate that Native Mexicans have a CYP2C9 genotype frequency similar to that of Asians, while Mestizos frequencies are closer to those of Caucasian descent (Castelan-Martinez et al, 2013;Scott et al, 2010;Aguilar et al, 2008;Dorado et al, 2010).…”

“…There are a couple of studies on the allele frequency of CYP2C9*2 and CYP2C9*3 in Mexican natives and Mestizos (Castelan-Martinez et al, 2013;Ross et al, 2010;Speed et al, 2009), but previous studies have not considered variants CYP2C9*4 and CYP2C9*5. Moreover, there are around 60 different native populations in Mexico and to the best of our knowledge this is the first time these variants are reported for the native populations of Tepehuanos, Mixtecos, and Zapotecos.…”

“…It is thus evident, that the collection and description of genetic diversity in the peoples of the Americas have just started. In this study, we aimed to assess the allele frequency of 11 variants in two genes relevant to oral anticoagulation therapy by expanding previous knowledge on the frequency of CYP2C9 alleles (Castelan-Martinez et al, 2013), and by describing frequencies of major alleles on VKORC1 in 300 Mestizos and 717 native individuals from Mexico. Our results contribute to the collection of the genetic diversity of the Mexican people, and aim to aid in the selection of drugs and doses whose pharmacokinetics or pharmacodynamics are associated with these genes.…”

CYP2C9, CYP2C19, ABCB1 genetic polymorphisms and phenytoin plasma concentrations in Mexican-Mestizo patients with epilepsy

“…[29][30][31][32] In both our patient and volunteer MM samples, we observed a predominance of the wild-type CYP2C19*1 allele, a low frequency of CYP2C19*2 and an absence of CYP2C19*3 allele, as it has been previously reported. [33][34][35][36][37][38] The frequency of CYP2C19*17 allele found in the present study (MM from Central Mexico) shows a minor nonsignificant difference from that found in a recent report in MM from the state of Jalisco (0.09 and 0.14, respectively).…”