Allele frequency distributions and other population genetic parameters for 13 STR loci in a UAE local population from Dubai

Alshamali, Farida; Alkhayat, A.; Budowle, Bruce; Watson, Nigel

doi:10.1016/s0531-5131(02)00625-8

Cited by 8 publications

(3 citation statements)

References 12 publications

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“…The number of alleles scored for each marker is an invaluable indicator of the future usefulness of the marker for genetic screening. Finding the same number of alleles for certain different loci in various populations (for example, Iran, Syrian, Emirates, Qatar and Egyptian populations) may indicate common ancestries (Reyhaneh and Sadeq, 2009;Alshamali et al, 2003;Ana et al, 2003;Clotilde et al, 2007). The frequency and the number of alleles, however, may be an indication for the degree of inbreeding within each population and thus reflects the homogeneity of the population.…”

Section: Allele Frequency Of Common Autosomal Genetic Locimentioning

confidence: 99%

“…The analysis of STR polymorphisms by PCR-based method offers certain advantages over RFLP typing. In recent years, short tandem repeat (STR) systems have gained importance in forensic analysis of biological specimens as well as in paternity testing, as an alternative to the use of restriction fragment length polymorphism (RFLP) analysis (Alshamali et al, 2003;Ana et al, 2003;Clotilde et al, 2007;Hammond et al, 1994). The analysis of STR polymorphisms by PCR-based method offers certain advantages over RFLP typing: (1) STR loci can be typed with a high degree of specificity and sensitivity in a short time period, (2) these loci can be successfully amplified from a limited amount of DNA even if it is degraded, and (3) typing of multiple loci can be accomplished in a single multiplex reaction (Hochmeister et al, 1991;Lins et al, 1996).…”

Section: Allele Frequency Of Common Autosomal Genetic Locimentioning

confidence: 99%

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Detection of new variant Off-ladder at the D12S391, D19S433 and D1S1656 loci and tri-allelic pattern at the D16S539 locus in a 21 locus autosomal short tandem repeat database of 400 Iraqi Individuals

Jebor¹,

Hameed²,

Kareem³

2015

Afr. J. Biotechnol.

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The objectives of the study included the detection of genetic variation of 21 autosomal short tandem repeats (STRs) loci from random unrelated individuals in the middle and South Arab people of Iraq, the Forensic efficiency parameters of the autosomal 21 genetic loci using power plex21® kit and to evaluate the importance of these loci for forensic genetic purposes and the possibility to use the new kit in routine practical work. FTA® Technology was utilized to extract DNA from blood collected on FTA™ paper. Twenty one (21) STR loci including D3S1358, D13S317, D19S433 and Amelogenin were amplified by using power plex21® kit. PCR products were detected by genetic analyzer 3130xL then, the data processed and analyzed by PowerStatsV1.2 software. Several statistical parameters of genetic and forensic efficiencies based on allelic frequencies have been estimated. This includes the observed heterozygosity (Ho), expected heterozygosity (He), paternity index (PI), random match probability (RMP), power of discrimination (PD), chance of exclusion (CE), polymorphic information content (PIC) and P-value. The power of discrimination values for autosomal tested loci was from 75 to 96% therefore those loci can be safely used to establish a DNA-based database for Iraq population for identifical purpose. The high PIC values of the selected markers confirm their usefulness for genetic polymorphism studies and linkage mapping programs in human as well. The mean heterozygosity observed, expected and mean PIC values across the 20 loci were 0.79, 0.83 and 0.81, respectively indicating high gene diversity. A total of nine off-ladder alleles and one tri-allelic pattern were detected in this study.

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Section: Allele Frequency Of Common Autosomal Genetic Locimentioning

confidence: 99%

Section: Allele Frequency Of Common Autosomal Genetic Locimentioning

confidence: 99%

Detection of new variant Off-ladder at the D12S391, D19S433 and D1S1656 loci and tri-allelic pattern at the D16S539 locus in a 21 locus autosomal short tandem repeat database of 400 Iraqi Individuals

Jebor¹,

Hameed²,

Kareem³

2015

Afr. J. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Finding the same number of alleles for certain different loci in various populations (e.g., Iran, Syrian, Emirates, Qatar and Egyptian populations) may indicate common ancestries (Reyhaneh et al, 2009;Alshamali et al, 2003;Ana et al, 2006;Clotilde et al, 2007). The frequency and the number of alleles, however, may be an indication for the degree of inbreeding within each population and thus reflects the homogeneity of the population.…”

Section: Allele Frequency Of Common Autosomal Genetic Locimentioning

confidence: 99%

Genetic variation of twenty autosomal STR loci and evaluate the importance of these loci for forensic genetic purposes

Hadi¹,

Abdullah²,

Jaber³

et al. 2014

Afr. J. Biotechnol.

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Autosomal microsatellite variability of the Arrernte people of Australia

Alfonso‐Sánchez¹,

Pérez-Miranda²,

Herrera³

2007

American J Hum Biol

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The genomic diversity of the Arrernte people of Australia or caterpillar people was investigated utilizing 13 autosomal short tandem repeat (STR) markers. Significant departures from Hardy-Weinberg equilibrium were detected at the D18S51, TPOX and CSF1PO loci, which persisted after applying the Bonferroni correction. Gene diversity values oscillate between 0.6302 (CSF1PO) and 0.8731 (D21S11). Observed heterozygosity (Ho) ranges from 0.2632 (D18S51) to 0.8333 (vWA) and is lower than the expected heterozygosity (He) for 12 of the 13 loci analyzed. The genetic relationships of the Arrernte with Middle Eastern, East Asian, South Asian and Indian populations were analyzed by distance-based methods, including Neighbor-Joining trees and nonmetric multidimensional scaling. In addition, the genetic contribution of the populations included in the analysis to the Arrernte gene pool was estimated utilizing weighted least square coefficients. Although the Arrernte population exhibits a remarkable level of genetic differentiation, results of the phylogeographic analyses based on autosomal microsatellite data suggest a certain degree of genetic relatedness between the Arrernte tribe of Australia and populations from the Indian subcontinent. In contrast, the STR diversity analyses failed to detect substantial East Asian contribution to the genetic background of the Arrernte group.

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Allele frequency distributions and other population genetic parameters for 13 STR loci in a UAE local population from Dubai

Cited by 8 publications

References 12 publications

Detection of new variant Off-ladder at the D12S391, D19S433 and D1S1656 loci and tri-allelic pattern at the D16S539 locus in a 21 locus autosomal short tandem repeat database of 400 Iraqi Individuals

Detection of new variant Off-ladder at the D12S391, D19S433 and D1S1656 loci and tri-allelic pattern at the D16S539 locus in a 21 locus autosomal short tandem repeat database of 400 Iraqi Individuals

Genetic variation of twenty autosomal STR loci and evaluate the importance of these loci for forensic genetic purposes

Autosomal microsatellite variability of the Arrernte people of Australia

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