2020
DOI: 10.1016/j.vas.2020.100114
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Allele frequency of nonsense mutation responsible for hereditary nephropathy in English cocker spaniel dogs

Abstract: Hereditary nephropathy is a primary progressive glomerular disease in dogs associated with the c.115A>T mutation in the COL4A4 gene in English cocker spaniel (ECS) dogs. The disease is inherited in an autosomal recessive manner. Hereditary nephropathy has been described in this breed since the late 1940s. To date, there are no data on the prevalence of this disease in Brazil, so the aim of this study was to evaluate the allelic frequency of this mutation in ECS dogs in this country. The … Show more

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