Allelic distribution of human leukocyte antigen in Iranian patients with pulmonary tuberculosis

Association of HLA-DRB alleles and pulmonary tuberculosis in North Chinese patients

“…HLA-DRB1*15 has been reported in many ethnic groups to be the main HLA allele associated with susceptibility, such as in the Indian population (Ravikumar et al, 1999;Sriram et al, 2001) and in the Mexican population (Teran-Escandon et al, 1999). Some results of other studies were different from ours, such as DRB1*12 in the Indonesian population (Yuliwulandari et al, 2010), DRB1*13 in the Polish population (Dubaniewicz et al, 2000), DRB1*14 in the Iranian population (Mahmoudzadeh-Niknam et al, 2003), and DRB1*1302 in the South African population (Lombard et al, 2006). The difference in HLA-DRB alleles between various populations can be explained partly by variation in the technique used, small sample size, and linkage disequilibrium.…”

“…As one of the host genetic factors, an association of HLA with susceptibility to tuberculosis has been studied in many ethnic groups, but the results are conflicting. HLA studies have revealed that the allele DRB1*15 is associated with tuberculosis in Indians (Sriram et al, 2001), DRB1*12 in Indonesians (Yuliwulandari et al, 2010), DRB1*13 in Polish (Dubaniewicz et al, 2000), DRB1*14 in Iranians (Mahmoudzadeh-Niknam et al, 2003), and DRB1*1302 in South Africans (Lombard et al, 2006). DRB1*0803 and DQB1*0601 were associated with tuberculosis disease progression in Koreans (Kim et al, 2005).…”

Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis

“…DRB1*16 is reported to have a positive association with the susceptibility to tuberculosis in Polish population (Dubaniewicz et al, 2005), but a negative association in the Sahariya tribe of North Central India (Mishra et al, 2014). DRB1*12 has been reported in the Indonesian population (Yuliwulandari et al, 2010), DRB1*13 in the Polish (Dubaniewicz et al, 2000), and South African populations (Lombard Z et al, 2006), and DRB1*14 in the Iranian (Mahmoudzadeh et al, 2003) and Portuguese populations (Duarte et al, 2011). The differences in the HLA-DRB alleles between the populations can be partly explained by the variation in the technique used, limited sample size and linkage disequilibrium.…”

Association of HLA-A, -B, and -DRB1 with pulmonary tuberculosis in western Javanese Indonesia

“…The discrepancies between the present results and those previously reported in Indonesian and other populations may be due to differences in resolution level of the genotyping method (DNA sequence based [11,14 -22] vs serologic based [9,10]), the sample size (most studies used low sample size with low statistical power) [10,12-18,20 -22], and the clinical features of the study participants (some studies used general TB patients [9 -18,20], whereas some others used the cases with various clinical subsets [19,21,22]. Alternatively, many earlier studies have focused mainly on HLA class II [9 -14,16,20 -22], whereas only a few studies have investigated both HLA class I and class II [15,[17][18][19]. Therefore an association of HLA-B alleles detected in this study may not have been reported.…”

“…Several studies have supported a weak to moderate association of HLA with TB; the implicated antigens include HLA-DR2, encoded by HLA-DR*15 and HLA-DR*16 alleles in Indians, Indonesians, and Poles [9 -13], -DR13 in Poles [14], -DR14 in Iranians [15], HLA-DQB1 in Cambodians and Poles [16,17], and HLA-DQw1 in Indonesians [10]. However, other studies have reported no such associations [18 -20].…”