Allelic diversity and haplotype structure of HLA loci in the Chinese Han population living in the Guanzhong region of the Shaanxi province

Shen, Chunmei; Zhu, Bo; Ye, Shi Hui; Liu, Meng Li; Yang, Guang; Liu, Sheng; Qin, Hai Xia; Zhang, Hua Dong; Lucas, Rudolf; Li, Shen Bing

doi:10.1016/j.humimm.2010.02.012

Cited by 23 publications

(29 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We analyzed these major alleles for the evaluation of the risk of disease severity, because rare alleles would have little impact on population risk. The data of the healthy control group in our study were compatible with the earlier data on the same Chinese Han population living in the Guanzhong region of the Shannxi Province [26, 27]. …”

Section: Resultssupporting

confidence: 91%

“…According to the study about the frequency of HLA haplotypes among the Guanzhong Han population, we observed six HLA A-B haplotypes, six HLA B-DRB1 haplotypes, and two HLA A-B-DRB1 haplotypes with frequencies higher than the others [27] and compared their frequencies between HFRS patients and normal controls. As shown in Table 4, neither the HLA A-B haplotypes nor the three loci haplotypes exhibited differences between patients and controls, whereas the two loci haplotypes HLA-B*46-DRB1*09 ( P = 0.040; OR = 2.16; 95% CI: 1.02–4.55) and HLA-B*51-DRB1*09 ( P = 0.037; OR = 3.62; 95% CI: 1.00–13.18) were more commonly shown in HFRS patients than controls.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population

Yuan

et al. 2012

Clinical and Developmental Immunology

View full text Add to dashboard Cite

The polymorphism of human leukocyte antigen (HLA), which is a genetic factor that influences the progression of hemorrhagic fever with renal syndrome (HFRS) after Hantaan virus (HTNV) infection, was incompletely understood. In this case-control study, 76 HFRS patients and 370 healthy controls of the Chinese Han population were typed for the HLA-A, -B, and -DRB1 loci. The general variation at the HLA-DRB1 locus was associated with the onset of HFRS (P < 0.05). The increasing frequencies of HLA-DRB1∗09 and HLA-B∗46-DRB1∗09 in HFRS patients were observed as reproducing a previous study. Moreover, the HLA-B∗51-DRB1∗09 was susceptible to HFRS (P = 0.037; OR = 3.62; 95% CI: 1.00–13.18). The increasing frequencies of HLA-B∗46, HLA-B∗46-DRB1∗09, and HLA-B∗51-DRB1∗09 were observed almost in severe/critical HFRS patients. The mean level of maximum serum creatinine was higher in HLA-B∗46-DRB1∗09 (P = 0.011), HLA-B∗51-DRB1∗09 (P = 0.041), or HLA-B∗46 (P = 0.011) positive patients than that in the negative patients. These findings suggest that the allele HLA-B∗46 and haplotypes HLA-B∗46-DRB1∗09 and HLA-B∗51-DRB1∗09 in patients could contribute to a more severe degree of HFRS and more serious kidney injury, which improve our understanding of the HLA polymorphism for a different outcome of HTNV infection.

show abstract

Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population

Yuan

et al. 2012

Clinical and Developmental Immunology

View full text Add to dashboard Cite

show abstract

“…This low frequency is an important information regarding the association that some of the B*27 alleles have with ankylosing spondylitis [30]. With regard to groups B*46, B*54 and B*59, which are also absent in the sample studied, they are almost exclusively characteristic of Mongoloid populations of East Asia, where they have a high frequency [5,31]. Among the most common HLA-B allele groups, B*35 is more frequent in Amerindian populations, but also, though less so, in European Mediterranean populations [5].…”

Section: Discussionmentioning

confidence: 77%

“…DRB1*09 is absent in the sample although it has a high frequency in populations of Eastern Asia and some Amerindian populations [5,31,33]. The most common DRB1*04 shows a high frequency in many populations of diverse origin, but it is found with the highest frequency among Amerindian populations [5,33,34].…”

Section: Discussionmentioning

confidence: 81%

HLA-A, -B, -C, -DQB1, and -DRB1,3,4,5 allele and haplotype frequencies in the Costa Rica Central Valley Population and its relationship to worldwide populations

et al. 2011

View full text Add to dashboard Cite

“…Therefore, the extensive allelic polymorphisms and the linkage disequilibrium among different HLA loci in different populations are usually used as highly polymorphic genetic markers in anthropology studies. Genetic distance calculation, cluster analysis and principal component analysis on the basis of the allelic frequencies at HLA loci in different populations have become valuable tools to study the genetic relationships among different ethnic groups as well as the origin, evolution and migration of the populations [12], [13].…”

Section: Introductionmentioning

confidence: 99%

Allele Polymorphism and Haplotype Diversity of HLA-A, -B and -DRB1 Loci in Sequence-Based Typing for Chinese Uyghur Ethnic Group

et al. 2010

Self Cite

View full text Add to dashboard Cite

BackgroundPrevious studies indicate that the frequency distributions of HLA alleles and haplotypes vary from one ethnic group to another or between the members of the same ethnic group living in different geographic areas. It is necessary and meaningful to study the high-resolution allelic and haplotypic distributions of HLA loci in different groups.Methodology/Principal FindingsHigh-resolution HLA typing for the Uyghur ethnic minority group using polymerase chain reaction-sequence-based-typing method was first reported. HLA-A, -B and -DRB1 allelic distributions were determined in 104 unrelated healthy Uyghur individuals and haplotypic frequencies and linkage disequilibrium parameters for HLA loci were estimated using the maximum-likelihood method. A total of 35 HLA-A, 51 HLA-B and 33 HLA-DRB1 alleles were identified at the four-digit level in the population. High frequency alleles were HLA-A*1101 (13.46%), A*0201 (12.50%), A*0301 (10.10%); HLA-B*5101(8.17%), B*3501(6.73%), B*5001 (6.25%); HLA-DRB1*0701 (16.35%), DRB1*1501 (8.65%) and DRB1*0301 (7.69%). The two-locus haplotypes at the highest frequency were HLA-A*3001-B*1302 (2.88%), A*2402-B*5101 (2.86%); HLA-B*5001-DRB1*0701 (4.14%) and B*0702-DRB1*1501 (3.37%). The three-locus haplotype at the highest frequency was HLA-A*3001-B*1302-DRB1*0701(2.40%). Significantly high linkage disequilibrium was observed in six two-locus haplotypes, with their corresponding relative linkage disequilibrium parameters equal to 1. Neighbor-joining phylogenetic tree between the Uyghur group and other previously reported populations was constructed on the basis of standard genetic distances among the populations calculated using the four-digit sequence-level allelic frequencies at HLA-A, HLA-B and HLA-DRB1 loci. The phylogenetic analyses reveal that the Uyghur group belongs to the northwestern Chinese populations and is most closely related to the Xibe group, and then to Kirgiz, Hui, Mongolian and Northern Han.Conclusions/SignificanceThe present findings could be useful to elucidate the genetic background of the population and to provide valuable data for HLA matching in clinical bone marrow transplantation, HLA-linked disease-association studies, population genetics, human identification and paternity tests in forensic sciences.

show abstract

Allelic diversity and haplotype structure of HLA loci in the Chinese Han population living in the Guanzhong region of the Shaanxi province

Cited by 23 publications

References 14 publications

The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population

The Genetic Polymorphisms of HLA Are Strongly Correlated with the Disease Severity after Hantaan Virus Infection in the Chinese Han Population

HLA-A, -B, -C, -DQB1, and -DRB1,3,4,5 allele and haplotype frequencies in the Costa Rica Central Valley Population and its relationship to worldwide populations

Allele Polymorphism and Haplotype Diversity of HLA-A, -B and -DRB1 Loci in Sequence-Based Typing for Chinese Uyghur Ethnic Group

Contact Info

Product

Resources

About