Allelic diversity distributions of 21 new autosomal short tandem repeat loci in Chinese Ningxia Han population

Wang, Hongdan; Liao, Shixiu; Shen, Chunmei; Liu, Wenjuan; Yuan, Guo-Lian; Zhang, Yu-Dang; Yang, Guang; Yan, Jiangwei; Qin, Haixia; Xie, Ting

doi:10.1016/j.fsigen.2012.11.012

Cited by 19 publications

(13 citation statements)

References 11 publications

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“…The compared results showed that the largest differences were found between Yi group and Uigur group , with differences at 13 loci; whereas the least differences were found in the Russian group , with differences at five loci. Significant differences of pairwise allelic frequency comparison were also observed between Yi group with Tujia , Kazak , Bai , Ningxia Han , Salar, and Tibetan groups at 6, 7, 7, 7, 8, and 12 STR loci, respectively. We found significant differences between Yi group and other four or more groups while calculating the single‐locus Fst and p ‐values using the AMOVA method for eight loci data including D10S1435, D22S1045, D4S2408, D1GATA113, D17S1301, D11S4463, D12ATA63, and D20S482.…”

Section: Resultsmentioning

confidence: 81%

“…Studies on the genetic relationships between different groups are of great significance to reveal the origin, migration, and evolution of ethnic groups. The previous studies have reported the genetic polymorphisms of 21 microsatellite loci in Ningxia Han , Northern Han population , Tibetan , Bai , Tujia , Uigur , Salar , Kazak , and Russian groups . Significant differences of allelic frequency distributions between these different ethnic groups were observed.…”

Section: Introductionmentioning

confidence: 98%

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Population genetics and forensic efficiency of twenty‐one novel microsatellite loci of Chinese Yi ethnic group

et al. 2013

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In this study, we investigated polymorphic distributions of allelic frequencies and forensic genetic parameters of 21 novel autosomal microsatellite loci from 110 unrelated healthy individuals of Chinese Yi ethnic group. Expected heterozygosity, power of discrimination, and polymorphic information content ranged from 0.617 to 0.812, 0.777 to 0.936 and 0.560 to 0.790. The microsatellite loci showed high forensic efficiency. The total discrimination power and cumulate probability of exclusion were 0.99999999999999999986902 and 0.999998818, respectively. Locus-by-locus allelic frequencies were compared using analysis of molecular variance (AMOVA) method, and the statistically significant differences were observed between Yi group and Russian, Tujia, Kazak, Bai, Ningxia Han, Salar, Tibetan, and Uigur groups at 5, 6, 7, 7, 7, 8, 12, and 13 loci, respectively. The results of genetic distance comparisons, genetic structure analyses, and principal component analysis all indicated that the Yi group showed relatively short genetic relationships with Russian, Salar, and Bai group. The experimental results showed that the 21 loci in the multiplex system provided highly polymorphic information and forensic efficiency for forensic individual identification and paternity testing, also basic population data for population genetics and anthropological research.

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Section: Resultsmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 98%

Population genetics and forensic efficiency of twenty‐one novel microsatellite loci of Chinese Yi ethnic group

et al. 2013

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“…The population structure analyses were conducted on the basis of the raw population data of the same 21 STR loci between the studied Kyrgyz and other previously published populations by the S tructre program. All the reference populations included nine populations from East Asia (Ningxia Han [ 19 ], Guanzhong Han [ 20 ], Tibetan [ 21 ], Bai [ 22 ], Yi [ 23 ], Russian [ 24 ], Salar [ 25 ], Tujia [ 26 ] and Mogolian [ 27 ]) and three populations from Central Asia (Chinese Kazak [ 28 ], Uygur [ 29 ] and the studied Kyrgyz). Each of K = 2–7 with 15 runs was carried out; then the optimum K was selected by S tructure H arvester v. 0.6.94 and the results are shown in the electronic supplementary material, figure S1, suggesting that K = 6 was the most appropriate configuration.…”

Section: Resultsmentioning

confidence: 99%

Forensic efficiency estimate and phylogenetic analysis for Chinese Kyrgyz ethnic group revealed by a panel of 21 short tandem repeats

et al. 2018

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Short tandem repeats (STRs) with a high level of polymorphisms and convenient detection method play an indispensable role in human population and forensic genetics. Recently, we detected the 21 autosomal non-combined DNA index system (non-CODIS) STR loci in a Kyrgyz ethnic group, calculated their forensic parameters and analysed its genetic relationships with reference populations from China. In total, 168 alleles were observed at 21 non-CODIS STRs with corresponding allelic frequencies from 0.0016 to 0.4788. No significant deviations at these STRs were observed from the Hardy–Weinberg equilibrium. The values of cumulative power of discrimination and probability of exclusion for all the 21 non-CODIS STRs were 0.99999999999999999998835 and 0.9999994002, respectively. Furthermore, the analyses of phylogenetic trees, genetic distances and interpopulation differentiations demonstrated that the Kyrgyz group had relatively close genetic relationships with the Uygur and Kazak groups. These 21 non-CODIS STRs were characterized by high genetic diversities in the Kyrgyz group and could be applied as a robust tool for individual identification and kinship testing in forensic sciences.

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“…Genotyping results of the 21 STR loci from 10 Chinese groups were chosen for population comparison, including Mongolian (n = 86) from Inner Mongolia autonomous region 6 , Bai (n = 106) from Yunnan province 7 , Kazak (n = 114) from Xinjiang autonomous region 8 , Ningxia Han (Northern Han) (n = 202) from Ningxia autonomous region 9 , Russian (n = 114) from Inner Mongolia autonomous region 10 , Tibetan (n = 104) from Tibet autonomous region 11 , Tujia (n = 107) from Hubei province 12 , Uigur (n = 218) from Xinjiang autonomous region 13 , Yi (n = 110) from Yunnan province 14 , Salar (n = 120) from Qinghai province 16 . The geographical locations of the reference populations were shown in Figure 1 .…”

Section: Methodsmentioning

confidence: 99%

“…And, it is necessary to analyze the allelic distribution of STR loci before used in forensic applications. We have so far reported population data 6 7 8 9 10 11 12 13 14 for a panel of 21 STR loci, and these STR loci demonstrated tremendous potential for forensic applications. In the present study, we first aimed to present the population genetic data and forensic parameters of the Chinese Guanzhong Han (Northern Han in geography) with a panel of 21 non-CODIS autosomal STRs.…”

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confidence: 99%

Genetic Variability and Phylogenetic Analysis of Han Population from Guanzhong Region of China based on 21 non-CODIS STR Loci

Zhang

Tang

Meng

et al. 2015

Sci Rep

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In the present study, we presented the population genetic data and their forensic parameters of 21 non-CODIS autosomal STR loci in Chinese Guanzhong Han population. A total of 166 alleles were observed with corresponding allelic frequencies ranging from 0.0018 to 0.5564. No STR locus was observed to deviate from the Hardy-Weinberg equilibrium and linkage disequilibriums after applying Bonferroni correction. The cumulative power of discrimination and probability of exclusion of all the 21 STR loci were 0.99999999999999999993814 and 0.999998184, respectively. The results of genetic distances, phylogenetic trees and principal component analysis revealed that the Guanzhong Han population had a closer relationship with Ningxia Han, Tujia and Bai groups than other populations tested. In summary, these 21 STR loci showed a high level of genetic polymorphisms for the Guanzhong Han population and could be used for forensic applications and the studies of population genetics.

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Allelic diversity distributions of 21 new autosomal short tandem repeat loci in Chinese Ningxia Han population

Cited by 19 publications

References 11 publications

Population genetics and forensic efficiency of twenty‐one novel microsatellite loci of Chinese Yi ethnic group

Population genetics and forensic efficiency of twenty‐one novel microsatellite loci of Chinese Yi ethnic group

Forensic efficiency estimate and phylogenetic analysis for Chinese Kyrgyz ethnic group revealed by a panel of 21 short tandem repeats

Genetic Variability and Phylogenetic Analysis of Han Population from Guanzhong Region of China based on 21 non-CODIS STR Loci

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