2022
DOI: 10.1101/2022.10.24.513455
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Allelic diversity uncovers protein domains contributing to the emergence of antimicrobial resistance

Abstract: Antimicrobial resistance (AMR) remains a major threat to global health. To date, tractable approaches that decipher how AMR emerges within a bacterial population remain limited. Here, we developed a framework that exploits genetic diversity from environmental bacterial populations to decode emergent phenotypes such as AMR. OmpU, is a porin that makes up to 60% of the outer membrane of Vibrio cholerae, the cholera pathogen. This porin is directly associated with the emergence of the bacterium and confers resist… Show more

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Cited by 3 publications
(11 citation statements)
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“…Modularity spans many scales in biological systems from genes, to cells, to ecosystems and provides a cohesive mechanistic framework to explain biological complexity [74][75][76][77] . Recently, we determined that the porin OmpU contains modular protein domains that uniquely contribute to the emergence of antimicrobial resistance in certain alleles 38 . Here, we unveil a new layer in the complex modular nature of the ompU ORF and demonstrate that OueS also displays modular characteristics.…”
Section: Discussionmentioning
confidence: 99%
See 4 more Smart Citations
“…Modularity spans many scales in biological systems from genes, to cells, to ecosystems and provides a cohesive mechanistic framework to explain biological complexity [74][75][76][77] . Recently, we determined that the porin OmpU contains modular protein domains that uniquely contribute to the emergence of antimicrobial resistance in certain alleles 38 . Here, we unveil a new layer in the complex modular nature of the ompU ORF and demonstrate that OueS also displays modular characteristics.…”
Section: Discussionmentioning
confidence: 99%
“…Modularity spans many scales in biological systems from genes, to cells, to ecosystems and provides a cohesive mechanistic framework to explain biological complexity [74][75][76][77] . Recently, we determined that the porin OmpU contains modular protein domains that uniquely contribute to the emergence of antimicrobial resistance in certain alleles 38 (NFC) of genetic information, which might be critical for the emergence of complex phenotypes. We contend this information is a) nested and fractal, as increasing the resolution within the unit ORF (nested) unveils successive layers of complexity (fractal), and b) compressed, as the overlapping of the coregulated modular porin gene with that of the modular sRNA confers a non-linear, finetuned regulation that is greater than the individual contributions of either of the two.…”
Section: Discussionmentioning
confidence: 99%
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