Allelic loss on chromosomes 2q, 3p and 21q: possibly a poor prognostic factor in oral squamous cell carcinoma

Yamamoto, Nobuharu; Mizoe, Jun Etsu; Numasawa, Hideyuki; Tsujii, Hirohiko; Shibahara, Takahiko; Noma, Hiroyasu

doi:10.1016/s1368-8375(03)00079-4

Cited by 33 publications

(27 citation statements)

References 27 publications

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“…68 In a study of LOH at 2q, 3p, and 21q it was shown that allelic loss in these regions is associated with the progression of OSCC and correlates with worse prognosis, particularly regarding 2q. 69 The molecular study of these loci may help select patients who should undergo more aggressive therapies.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano

Regateiro

Januário

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

548

436

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Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano

Regateiro

Januário

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

548

436

View full text Add to dashboard Cite

“…44,55 Furthermore, several studies have identified a negative prognostic role for LOH, 18,37,41,73,74 even in multivariate analyses. 34,35,46 This negative prognostic value is mostly connected to allelic loss at 3p, 8p, 11q, 13q, 17p and 18q.…”

Section: Prognostic Valuementioning

confidence: 99%

The clinical relevance of microsatellite alterations in head and neck squamous cell carcinoma: a critical review

Schutter¹,

Spaepen²,

Bride

et al. 2007

Eur J Hum Genet

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Triggered by the existing confusion in the field, the current paper aimed to review the current knowledge of both microsatellite instability (MSI) and loss of heterozygosity (LOH) detected by microsatellite markers in head and neck squamous cell carcinoma (HNSCC), and to provide the reader with an assessment of their prognostic and predictive value in this tumor type. For both MSI and LOH, various detection methods were included such as mono-and polynucleotidemarkers and gel-as well as automated analyses. Only studies based on PCR techniques with microsatellite markers were considered. Taking the methodological problems occurring in investigations with microsatellite markers into account, LOH seems to be more common than MSI in HNSCC. Although both types of microsatellite alterations have been correlated with clinicopathological features of this tumor type, only LOH seems to have a clear prognostic value. The predictive value of both MSI and LOH is debatable. More research has to be performed to clearly establish LOH detection as a translational application in the HNSCC field, aiming to predict response to treatments or outcome, and eventually to use as a therapeutic target.

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“…23 A variety of potential tumor suppressor genes like CASP10, BARD1, XRCC5 and PPP1R7 have been excluded as targets of mutational inactivation. 21 Deletions in 2q36 have been found in early cervix carcinoma and in precancerous lesions, but in contrast to our results also in PSCC in high tumor stages.…”

Section: Discussionmentioning

confidence: 99%

Screening of microsatellite markers in penile cancer reveals differences between metastatic and nonmetastatic carcinomas

et al. 2007

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Penile cancer, observed only rarely in the western world, represents a carcinoma that may be cured by resection of primary lesion and in case of lymph node metastasis by early lymph node dissection. This early inguinal lymphadenectomy bares a significant better survival even in cases of nonpalpable lymph nodes, but carries also a high risk of overtreatment, especially in lower tumor stages. Due to the low incidence, only few data are available on the molecular genetic background of this tumor, especially concerning tumor progression and metastasis. Therefore, we studied 62 microsatellite markers in 28 penile carcinomas searching for markers predicting progression or outcome. LOH in more than 25% of primary tumors was found on six different chromosomes, including 2q, 6p, 8q, 9p, 12q and 17p13. Statistically significant correlations could be established in D6S260 to clinical outcome and in markers from chromosomes 6, 9 and 12 to tumor stage and metastasis. These regions are worthy for further analysis concerning tumor suppressor genes and metastasis suppressor genes. Keywords: penile carcinoma; microsatellite marker; LOH; HPV; metastasis Penile squamous cell carcinoma (PSCC) is an uncommon tumor entity in North America and Europe (incidence of 1/100 000). PSCC is characterized by a slow regional tumor progression and frequent metastases of inguinal lymph nodes. The incidence of lymph node metastasis varies from 0-30% in T1 tumors to 25-50% in T2-T3 stages 1 and has been established as the main variable for the survival of patients. PSCC may be cured by resection of primary lesion and involved regional lymph nodes, but inguinal lymphadenectomy is associated with a high risk for complications, such as wound infection, necrosis and moderate to severe lymphedema and a higher mortality. 2,3 Therefore, accurate diagnosis of metastasis is required and the detection of reliable markers for the occurrence of metastasis would result in a great benefit for the patients. In this context, several histopathological factors of the primary penile tumor have been discussed, for example tumor stage, histopathological growth pattern, grade of differentiation, depth of invasion and presence of angioinvasion. [3][4][5][6][7] Additionally, the over-or underexpression of certain proteins has been examined for its importance in tumor progression. Martins et al 8 reported a prognostic significance of tumor suppressor gene p53 and a significant correlation between proliferation cell nuclear antigen and lymph node metastasis. A significant shorter survival in patients with positive p53 immunoreaction of their tumors in combination with detection of HPV DNA has also been demonstrated. 9 Nevertheless, only few studies searched for DNA aberrations in penile carcinoma. Alves et al 10 presented deletions in 13q21-22 and 4q21-32 by means of comperative genomic hybridization. Humbey et al 11 found genetic alterations in exon 4 of the p53 region. No further information about genetic imbalances in penile carcinomas is known until now. Therefore, we ...

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Allelic loss on chromosomes 2q, 3p and 21q: possibly a poor prognostic factor in oral squamous cell carcinoma

Cited by 33 publications

References 27 publications

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Oral squamous cell carcinoma: Review of prognostic and predictive factors

The clinical relevance of microsatellite alterations in head and neck squamous cell carcinoma: a critical review

Screening of microsatellite markers in penile cancer reveals differences between metastatic and nonmetastatic carcinomas

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