Allelic variants of human genes affecting HIV intracellular life cycle and regulating immune response to HIV infection

Хаитов, Р. М.; Alexeev, L.; Гудима, Г.О.; Кофиади, И.А.

doi:10.20538/1682-0363-2019-1-119-130

Search citation statements

Order By: Relevance

Paper Sections

Select...

For Correspondence1

Citation Types

Supporting

Mentioning

Contrasting

Unclassified

Year Published

2020

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Понимание структуры и жизненного цикла вирусанеобходимое условие для разработки эффективных способов профилактики ассоциированных с ним заболеваний [30,31]. Одним из наиболее действенных и доминирующих способов снижения заболеваемости является иммунизация населения с помощью вакцин.…”

Section: For Correspondenceunclassified

Epstein-Barr virus: vaccine development

Solomay¹,

Semenenko²,

Филатов³

et al. 2020

Immunologiya

View full text Add to dashboard Cite

Section: For Correspondenceunclassified

Epstein-Barr virus: vaccine development

Solomay¹,

Semenenko²,

Филатов³

et al. 2020

Immunologiya

View full text Add to dashboard Cite

Principles of Creation of a Genetic Engineering Construction for Obtaining Humanized Transgenic Mice with <i>HLA-C*07:02:01:01</i>, as a Promote of Innovative Transgenic and Knockout Biomodels

Karkischenko,

Lazarev,

Manuvera

et al. 2024

BIOMEDICINE

View full text Add to dashboard Cite

Genetic differences in different populations influence the mechanism and efficacy of drugs. Biomodels that take into account the peculiarities of genetic polymorphism in different individuals allow to more fully investigate the molecular-genetic mechanisms of action of pharmacological agents, including immunobiological ones. Recombinant DNA encoding a hybrid MHC class I protein containing human ß2-microglobulin fused with antigen-presenting domains (α1 and α2 domains) of the HLA-C*07:02:01:01 molecule and α3 domain of the mouse H2-complex was created. The purified linearized DNA fragment containing the target construct flanked by regulatory fragments ensuring its stable transcription was used to obtain a new line of humanized transgenic mice. The principles of designing humanized transgenic mice by encoding a chimeric MHC class I protein containing antigen-presenting domains HLA-C*07:02:01:01 are similar to those for obtaining mice of the HLA-А*02:01:01 and HLA-B*18:01:01:02 humanized transgenic lines. These transgenic lines of laboratory mice are independent biomodels, and also be used as baselines for obtaining corresponding transgenic and knockout lines.

show abstract

Allelic variants of human genes affecting HIV intracellular life cycle and regulating immune response to HIV infection

Cited by 2 publications

References 58 publications

Epstein-Barr virus: vaccine development

Epstein-Barr virus: vaccine development

Principles of Creation of a Genetic Engineering Construction for Obtaining Humanized Transgenic Mice with <i>HLA-C*07:02:01:01</i>, as a Promote of Innovative Transgenic and Knockout Biomodels

Contact Info

Product

Resources

About