Allelic variants of &lt;i&gt; DYX1C1&lt;/i&gt; are not associated with dyslexia in India

Saviour, Pushpa; Kumar, Satish; Kiran, Usha; Ravuri, Rajasekhara Reddy; Rao, V. R.; Ramachandra, Nallur B.

doi:10.4103/0971-6866.45002

Cited by 14 publications

(3 citation statements)

References 16 publications

(18 reference statements)

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“…Several previous studies of dyslexia also failed to find any association with this SNP [18], [22], [23], [25], [26], although some studies on Caucasian populations that use an alphabetic language reported a positive association [14], [15], [19], [21]. As mentioned above, discrepancies between these studies may due to language differences, sex effects, and many other factors.…”

Section: Discussionmentioning

confidence: 84%

“…DYX1C1 (dyslexia susceptibility 1 candidate 1) was first identified as a candidate gene for dyslexia susceptibility in a Finnish family transmitting a chromosome translocation [t(2; 15)(q11; q21)] that segregated with dyslexia [15] . Subsequently, multiple studies have supported the association between DYX1C1 and dyslexia, although not all [13] , [14] , [16] – [26] . The most widely replicated SNPs are rs3743205 (-3G/A) and rs57809907 (1249G/T) [13] , [14] , [15] , [17] , [20] , [21] .…”

Section: Introductionmentioning

confidence: 99%

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Association of the DYX1C1 Dyslexia Susceptibility Gene with Orthography in the Chinese Population

Zhang

Tardif

et al. 2012

PLoS ONE

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Several independent studies have supported the association of DYX1C1 with dyslexia, but its role in general reading development remains unclear. Here, we investigated the contribution of this gene to reading, with a focus on orthographic skills, in a sample of 284 unrelated Chinese children aged 5 to 11 years who were participating in the Chinese Longitudinal Study of Reading Development. We tested this association using a quantitative approach for Chinese character reading, Chinese character dictation, orthographic judgment, and visual skills. Significant or marginally significant associations were observed at the marker rs11629841 with children's orthographic judgments at ages 7 and 8 years (all P values<0.020). Significant associations with Chinese character dictation (all P values<0.013) were also observed for this single-nucleotide polymorphism (SNP) at ages 9, 10, and 11 years. Further analyses revealed that the association with orthographic skills was specific to the processing of specific components of characters (P values<0.046). No association was found at either SNP of rs3743205 or rs57809907. Our findings suggest that DYX1C1 influences reading development in the general Chinese population and supports a universal effect of this gene.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Association of the DYX1C1 Dyslexia Susceptibility Gene with Orthography in the Chinese Population

Zhang

Tardif

et al. 2012

PLoS ONE

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“…Furthermore, several studies failed to replicate the initial association of rs3743205‐ DYX1C1 found by Taipale et al. (2003) (Bellini et al., 2005; Brkanac et al., 2007; Marino et al., 2005, 2007; Newbury et al., 2011; Saviour et al., 2008; Wigg et al., 2004). …”

Section: Discussionmentioning

confidence: 99%

ATP2C2andDYX1C1are putative modulators of dyslexia‐related MMR

et al. 2017

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BackgroundDyslexia is a specific learning disorder affecting reading and spelling abilities. Its prevalence is ~5% in German‐speaking individuals. Although the etiology of dyslexia largely remains to be determined, comprehensive evidence supports deficient phonological processing as a major contributing factor. An important prerequisite for phonological processing is auditory discrimination and, thus, essential for acquiring reading and spelling skills. The event‐related potential Mismatch Response (MMR) is an indicator for auditory discrimination capabilities with dyslexics showing an altered late component of MMR in response to auditory input.MethodsIn this study, we comprehensively analyzed associations of dyslexia‐specific late MMRs with genetic variants previously reported to be associated with dyslexia‐related phenotypes in multiple studies comprising 25 independent single‐nucleotide polymorphisms (SNPs) within 10 genes.ResultsFirst, we demonstrated validity of these SNPs for dyslexia in our sample by showing that additional inclusion of a polygenic risk score improved prediction of impaired writing compared with a model that used MMR alone. Secondly, a multifactorial regression analysis was conducted to uncover the subset of the 25 SNPs that is associated with the dyslexia‐specific late component of MMR. In total, four independent SNPs within DYX1C1 and ATP2C2 were found to be associated with MMR stronger than expected from multiple testing. To explore potential pathomechanisms, we annotated these variants with functional data including tissue‐specific expression analysis and eQTLs.ConclusionOur findings corroborate the late component of MMR as a potential endophenotype for dyslexia and support tripartite relationships between dyslexia‐related SNPs, the late component of MMR and dyslexia.

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Genetic variant inKIAA0319, but not inDYX1C1, is associated with risk of dyslexia: An integrated meta‐analysis

Zou

Chen

Shao

et al. 2012

American J of Med Genetics Pt B

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DYX1C1 and KIAA0319 have been two of the most extensively studied candidate genes for dyslexia given their important roles in the neuronal migration and neurite growth. The -3G > A in DYX1C1 and the 931C > T in KIAA0319 were of special interest for dyslexia but with inconsistent results. We performed a meta-analysis integrating case-control and transmission/disequilibrium test (TDT) studies to clearly discern the effect of these two variants in dyslexia. Data from case-control and TDT studies were analyzed in an allelic model using the Catmap software. In overall meta-analysis, the pooled OR for the -3A allele and the 931T allele was 0.68 (95% CI = 0.25-1.87, P(heterogeneity) = 0.000) and 0.87 (95% CI = 0.78-0.98, P(heterogeneity)= 0.125), respectively. The stratified analysis showed that the between-study heterogeneity regarding the -3G > A polymorphism might be accounted by the publication year. Additionally, the sensitivity analysis of -3G > A polymorphism indicated the stability of the result. In conclusion, our results suggested that the 931C > T variant in KIAA0319, but not the -3G > A in DYX1C1, was significantly associated with the risk of dyslexia.

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Allelic variants of <i> DYX1C1</i> are not associated with dyslexia in India

Cited by 14 publications

References 16 publications

Association of the DYX1C1 Dyslexia Susceptibility Gene with Orthography in the Chinese Population

Association of the DYX1C1 Dyslexia Susceptibility Gene with Orthography in the Chinese Population

ATP2C2andDYX1C1are putative modulators of dyslexia‐related MMR

Genetic variant inKIAA0319, but not inDYX1C1, is associated with risk of dyslexia: An integrated meta‐analysis

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