Allelic variations in the vitamin D receptor gene, insulin secretion and parents' heights are independently associated with height in obese children and adolescents

Ferrarezi, Daniela A.F.; Bellili-Muñoz, Naima; Nicolau, Carla Marques; Cheurfa, Nadir; Guazzelli, Isabel; Frazzatto, Eliana; Velho, Gilberto; Villares, S M

doi:10.1016/j.metabol.2012.03.018

Cited by 25 publications

(18 citation statements)

References 52 publications

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“…Regarding American populations, in a recent study conducted on 1,773 healthy women aged 35-80 from Western New York State (USA), the VDR rs3782905 polymorphism was positively associated with adiposity markers [29]. In relation to children, allelic variation in VDR was found to be associated with obesity in a population of children and adolescents from Brazil [30]. Contrarily, a study conducted in a Saudi cohort identified that the VDR TaqI_G and Bsm-I_T minor allele polymorphisms were significantly more frequent in obese individuals [31].…”

Section: Vdr Genetic Variantsmentioning

confidence: 98%

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Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship

et al. 2018

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Vitamin D (vitD) deficiency is associated with a wide range of chronic diseases and conditions, including obesity, and with an increasing severity of metabolic dysregulation, such as insulin resistance, hyperlipidemia, liver disease, and hypertension, both in children and adults. However, the nature of the association between low vitD status and obesity remains unclear. This fact has motivated the scientific community to conduct genetic association analyses between 25-hydroxyvitamin D (25[OH]D)-related genes and obesity traits. In this line, the variation in the vitD receptor (VDR) gene represents the bulk of the findings. Specifically, polymorphisms in the VDR gene have been associated with obesity traits in some but not all, studies. Thus, results regarding this matter remain inconclusive. Other genes aside from VDR have also been investigated in relation to obesity-related traits. However, again, findings have been inconsistent. In general, results point to the fact that the DBP/GC gene could be an important protein-linking obesity and vitD status. On the other hand, several studies have attempted to determine the molecular mechanism of the relationship between 25(OH)-D levels and obesity. Some of these studies suggest that vitD, due to its fat-soluble characteristic, is retained by the adipose tissue and has the capacity to metabolize 25(OH)-D locally, and this can be altered during obesity. Additionally, vitD is capable of regulating the gene expression related to adipogenesis process, inflammation, oxidative stress, and metabolism in mature adipocytes. Therefore, the aim of the present review was to evaluate the association between obesity and vitD deficiency describing the main molecular mechanism of the relationship and the link with genetic factors. Key Messages: Low serum 25(OH)-D is positively associated with obesity or BMI in adults and children. Circulating vitD concentrations are, at least, partially determined by genetic factors. VitD plays an important role in the adipogenesis process and inflammation status in adipocytes and adipose tissue.

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Section: Vdr Genetic Variantsmentioning

confidence: 98%

“…rs1544410 BsmI C (T) Significantly more frequent in Saudi obese individuals [31,32]. Positive correlations with height and with lean body mass in Brazilian obese children [30]. Higher BMI in postmenopausal Vietnamese women [33].…”

Section: Vitd and Adipogenesismentioning

confidence: 99%

Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship

et al. 2018

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“…Poomthavorn et al (2012) found no relationship between serum 25(OH)D and HOMA-IR, WBISI, fasting plasma glucose, fasting insulin or 2-hour plasma glucose in Thai obese adolescents. Moreover, no correlations with glucose tolerance, insulin sensitivity or insulin secretion were observed by Ferrarezi et al (2012) with Brazilian obese adolescents, and neither by Erdönmez et al (2011) Furthermore, many studies included children in their analysis (which means non-pubertal subjects), which may impact differently the studied metabolic pathways. Khadgawat et al (2012), evaluating the influence of puberty on glucose metabolism in obese individuals from 6 to 17 years old, reported an inverse relationship between 25(OH)D and HOMA-IR only in postpubertal ones.…”

Section: Vitamin D Status and Glucose Metabolism In Youthmentioning

confidence: 97%

Vitamin D status and glucose metabolism in youth

Giudici

Souza

Martini

2015

Critical Reviews in Food Science and Nutrition

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This study aimed to review and synthesize the available scientific evidence on the relationship between serum 25(OH)D concentrations and glucose metabolism among adolescents. A total of 19 studies were included. Many studies did not find a relation between 25(OH)D concentrations and insulin sensitivity, but most studies have shown that vitamin D status influences glucose dysregulation in youth due to particularities of this life stage. Considering the prevalence of vitamin D deficiency and insufficiency were high among adolescents, the importance for vitamin D status correction in this young group, in which chronic diseases are not expected but getting every day more common, is mandatory.

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“…Se identificaron tres polimorfismos en los nucleótidos rs1544410 (Bsm I), rs7975232 (Apa I) y rs731236 (Taq I), siendo Taq l el único en el que se encontró una asociación estadísticamente significativa 64 .…”

Section: Polimorfismos Genéticos Asociados a Hipovitaminosis D Y Cierunclassified

Hipovitaminosis D: una visión desde la clínica y la biología molecular

Gallego-González

Mejía-Mesa

Martínez-Sánchez

et al. 2017

revmed

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ResumenLa vitamina D es una hormona que participa en gran cantidad de procesos fisiológicos y bioquímicos dentro del organismo humano, tales como la absorción de calcio y fosfato a nivel intestinal, regulación de la calcemia y mineralización ósea; además, tiene efectos sobre el ciclo celular, proliferación, diferenciación, señalización, apoptosis y producción de varias moléculas en diferentes células y tejidos, lo que explica la relación de sus bajos niveles con el desarrollo de múltiples patologías. En los últimos años, se ha reportado una elevada prevalencia de hipovitaminosis D a nivel mundial, que oscila entre el 50 y 92% según la población estudiada, producto de la deficiente exposición a la luz solar, escasa ingesta dietética, poco uso de suplementos vitamínicos, entre otros factores asociados. A su vez, se ha encontrado que la deficiencia de vitamina D es causada por algunos polimorfismos genéticos que afectan su metabolismo y conllevan al desarrollo de varias enfermedades. Debido a la importancia clínica de la vitamina D, se realizó esta revisión de la literatura por medio de la búsqueda de artículos originales, revisiones sistemáticas y narrativas en las bases de datos Pubmed y ScienceDirect y en el buscador Google Scholar. Se seleccionaron en total 71 artículos, a partir de los cuales se busca describir en el presente texto algunos de los aspectos relacionados con la fisiología, epidemiología, clínica y etiología de la hipovitaminosis D. Vitamin D deficiency: a view from clinical features and molecular biology AbstRActVitamin D is a hormone involved in many physiological and biochemical processes within the human, such as the absorption of calcium and phosphate in the intestine, regulation of blood calcium and bone mineralization; it also has effects on the cell cycle, proliferation, differentiation, signaling, apoptosis and production of various molecules in different cells and tissues, which explains the relationship between low levels of vitamin D and the development of many diseases. In recent years, there has been reported a high prevalence of vitamin D deficiency worldwide, ranging between 50 and 92% depending on the population studied, the result of poor exposure to sunlight, poor dietary intake, little use of vitamin supplements, among other associated factors. Hence, it has been found that vitamin D deficiency is caused by some genetic polymorphisms that affect their metabolism and lead to the development of various diseases. Because of the clinical importance of vitamin D, this review of the literature was conducted by the search for original articles, systematic reviews and narrative articles in PubMed, ScienceDirect and Google Scholar reviews. They were selected in total 71 articles, from which we seek to describe here some of the aspects of physiology, epidemiology, clinical and etiology of vitamin D deficiency. mÉD.uIs. 2017;30(1):45-56.

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Allelic variations in the vitamin D receptor gene, insulin secretion and parents' heights are independently associated with height in obese children and adolescents

Cited by 25 publications

References 52 publications

Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship

Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship

Vitamin D status and glucose metabolism in youth

Hipovitaminosis D: una visión desde la clínica y la biología molecular

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