Allelopathic activity of Nepeta nuda L. subsp. nuda water extracts

Dragoeva, Asya; Stoyanova, Zheni; Koleva, Vanya; Dragolova, D.

doi:10.1515/asn-2017-0007

Cited by 7 publications

(7 citation statements)

References 23 publications

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“…Due to its pleasant aroma, which is similar to citrus and peppermint, it can be used in the food industry as an additive in juices [34], or in the pharmaceutical industry for mouthwash preparations [28]. In addition, this plant could be used to develop bio-herbicides due to its genotoxicity [10,35,36]. Nevertheless, investigations show that N. nuda essential oils have the great bioactive potential [8,10,12,[14][15][16][17]33,35]; thus, in order to be able to standardize a recipe for specific preparation, it is necessary to examine the stability of the chemical composition of the raw material.…”

Section: Introductionmentioning

confidence: 99%

Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia)

et al. 2022

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Unlike other studies that only determined the chemical composition of essential oils depending on their geographic origin, this research investigated the effect of weather conditions (temperature, precipitation, and insolation) on the chemical composition of Nepeta nuda L. essential oil. The collection of wild-growing N. nuda was carried out during three successive years, 2019, 2020, and 2021 at Rtanj Mountain (Serbia) on the same date (July 7th). Essential oil extraction from the plant was performed by hydro-distillation. After gas chromatographic-mass spectrometric analysis, a total of 102 volatile compounds were separated from N. nuda, during the observed period, 28 were unidentified, compromising between 5.0% and 8.7%, depending on the year. A multiple linear regression model was created, and statistical analyses were performed to provide knowledge about the prediction, feature profile, and the similarity in contents of active compounds of the N. nuda essential oil. The influence of temperature on the accumulation of the most abundant component, 1,8-cineole, was positive, while the impact of precipitation and insolation was negative. According to the cluster tree, there are four chemotypes of N. nuda essential oil: with nepetalactone, 1,8-cineole, mixed (nepetalactone+1,8-cineole+germacrene D), and nonspecific chemotypes. Bearing in mind that the biological activity of a raw material depends on the chemotype and environmental factors, this is a topic that deserves a more detailed approach. The N. nuda and its essential oil are promising materials with high biological potential, and these deserve further detailed investigation.

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Section: Introductionmentioning

confidence: 99%

Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia)

et al. 2022

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“…In our previous studies allelopathic effects of adonis, oregano and nepeta has been studied [13,14,15]. Based on our results, in present study plant solutions were prepared at following concentrations: Adonis vernalis -1.83 mg/ml, Origanum vulgare ssp.…”

Section: Methodsmentioning

confidence: 98%

“…vulgare L. and Nepeta nuda subsp. Nuda (Lamiaceae) and Adonis vernalis L. (Ranunculaceae) on plant test system [13,14,15]. Present study aimed to evaluate the effect of the same extracts in vitro on proliferation/viability of human hepatoma cell line SK-HEP-1 in vitro.…”

Section: Introductionmentioning

confidence: 99%

In vitro cytotoxicity of allelopathic plants Adonis vernalis L. Origanum vulgare ssp. vulgare L. and Nepeta nuda subsp. nuda

Koleva

Dragoeva

Stoyanova

et al. 2018

Acta Scientifica Naturalis

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Medicinal plants produce various secondary metabolites as a part of their chemical defence and survival in nature. These compounds have a wide range of biological activities. Nowadays, medicinal plants are used as source of allelochemicals and new effective anticancer agents. Our previous studies revealed allelopathic potential of water extracts of Adonis vernalis L. (Ranunculaceae), Origanum vulgare ssp. vulgare L. and Nepeta nuda subsp. nuda (Lamiaceae). Present study aimed to evaluate the effect of the same extracts in vitro on human hepatoma cell line SK-HEP-1. Cell proliferation/viability was assessed using Premixed WST-1 Cell Proliferation Reagent.Adonis water extract (1.83mg/ml) had notable negative influence on cancer cell line tested. Oregano (3.5 mg/ml) also exerted negative effect, but to a lesser degree. On the contrary, nepeta water extract (6.59 mg/ml) had an opposite effect, stimulating cell proliferation. One possible explanation could be the type of extraction: after treatment with nepeta methanol extract (6.59 mg/ml) cell viability was significantly reduced.In conclusion, Adonis vernalis and Nepeta nuda subsp. nuda possess metabolites with growth inhibitory effect on human hepatoma cell line SK-HEP-1. Further research is needed to clarify biological activity of lower concentrations which are appropriate to enable the design of new anticancer drugs.

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“…For instance, subspecies rich in 1,8cineole could be used in traditional medicine for inhalation (Chalchat et al, 1998), while subspecies rich in sesquiterpene alcohol nerolidol could be used either in cosmetics and household products or as food flavoring agents (Chan et al, 2016). According to review, N. nuda possesses antimicrobial (Alim et al, 2009;Gormez et al, 2013;Smiljković et al, 2018;Ðordević et al, 2019) and virocidal activity (Angelova et al, 2016;Todorov et al, 2015), as well as antioxidant (Alim et al, 2009;Aras et al, 2016b;a;Cvetković et al, n.d.;Sarikurkcu et al, 2018;2019;Ðordević et al, 2019), anticancer (Kabalay et al, 2018), and allelopathic (Bozari et al, 2013;Bozok et al, 2017;Dragoeva et al, 2017) properties. It has been reported that nepetalactones have antibacterial, antifungal, insecticidal and antioxidant activities (Adiguzel et al, 2009;Grbic-Ljaljevic et al, 2008;Reichert et al, 2019;Shafaghat and Oji, 2010;Zhu et al, 2012).…”

Section: Pharmacologymentioning

confidence: 99%

“…Different concentrations (2, 4, 6, 8, 10, 12 and 14 g/l) of N. nuda subsp. nuda water extract were tested for phytotoxic effects on wheat and cucumber (Dragoeva et al, 2017). Results of this experiment showed that even though germination was not affected, N. nuda extract caused deterioration in seedling growth.…”

Section: Other Properties/toxicologymentioning

confidence: 99%

Phyto-pharmacological aspects of Nepeta nuda L.: A systematic review

Aćimović¹,

Jeremić

Cvetković

2020

Lekovite sirovine

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Nepeta nuda L. (syn. N. pannonica L.) is a herbaceous perennial plant that is the most widespread species of the genus Nepeta, the largest genera in Lamiaceae family. N. nuda is divided into four subspecies according to morphological differences which occur within large geographical range of distribution: subsp. nuda, subsp. albiflora, subsp. lydiae, and subsp. glandulifera. In this review, previous reports on N. nuda concerning its botanical description and systematics, phytochemistry, use in traditional medicine, pharmacology, and posibilities for other applications were summarized. All of these data indicate N. nuda as a highly promising species for application in food and pharmaceutical industries, as well as in agriculture for the development of natural pesticides.

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Allelopathic activity of Nepeta nuda L. subsp. nuda water extracts

Cited by 7 publications

References 23 publications

Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia)

Volatile Compounds of Nepeta nuda L. from Rtanj Mountain (Serbia)

In vitro cytotoxicity of allelopathic plants Adonis vernalis L. Origanum vulgare ssp. vulgare L. and Nepeta nuda subsp. nuda

Phyto-pharmacological aspects of Nepeta nuda L.: A systematic review

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