2016
DOI: 10.1097/aci.0000000000000233
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Allergen-encoded signals that control allergic responses

Abstract: Purpose of review The purpose is to review the important recent advances made in how innate immune cells, microbes, and the environment contribute to the expression of allergic disease, emphasizing the allergen-related signals that drive allergic responses. Recent findings The last few years have seen crucial advances in how innate immune cells such as innate lymphoid cells group 2 and airway epithelial cells and related molecular pathways through organismal proteinases and innate immune cytokines, such as t… Show more

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Cited by 5 publications
(3 citation statements)
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“…However, there is now increasing interest in the mechanisms by which respiratory microbes may perturb pulmonary immune responses and in particular how epithelial stimulation from microbial proteases may elicit Th2-type inflammation, with production of IL-4, IL-5 and IL-13 (for example) by other cells of the immune system such as innate lymphoid cells [41, 42]. …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, there is now increasing interest in the mechanisms by which respiratory microbes may perturb pulmonary immune responses and in particular how epithelial stimulation from microbial proteases may elicit Th2-type inflammation, with production of IL-4, IL-5 and IL-13 (for example) by other cells of the immune system such as innate lymphoid cells [41, 42]. …”
Section: Discussionmentioning
confidence: 99%
“…There is a growing research field investigating the pulmonary microbiome in airway diseases: a prevailing theory is that loss of microbial diversity in patients with asthma may be responsible for dysregulated pulmonary immune tolerance and onset of disease pathology [ 40 ]. However, there is now increasing interest in the mechanisms by which respiratory microbes may perturb pulmonary immune responses and in particular how epithelial stimulation from microbial proteases may elicit Th2-type inflammation, with production of IL-4, IL-5 and IL-13 (for example) by other cells of the immune system such as innate lymphoid cells [ 41 , 42 ].…”
Section: Discussionmentioning
confidence: 99%
“…Environmental proteinases are increasingly recognized to be critical drivers of both allergies, the subset of allergic diseases that are driven by IgE-dependent type 1 hypersensitivity reactions, and allergic airway disease that is mediated by both lymphocytes and IgE-dependent immune reactions (3). Canonical environmental allergens such as pollens, dust mites, cockroaches and other arthropods, and pet danders are all important sources of active proteinases that alone or combined as part of whole-organism extracts readily induce experimental allergic airway disease in rodents (4).…”
mentioning
confidence: 99%