Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis

Yao, Yin; Wang, Zhichao; Wang, Nan; Zhou, Pengcheng; Chen, Cailing; Song, Jia; Li, Pan; Liao, Bo; Zhang, Xin‐Hao; Yang, Y J; Xu, Xiaoyan; Zhu, Rongfei; Yu, Di; Liu, Zheng

doi:10.1016/j.jaci.2019.02.008

Cited by 82 publications

(134 citation statements)

References 42 publications

Supporting

Mentioning

124

Contrasting

Order By: Relevance

“…Whether there are very rare Tfr cells in humans that are clear counterparts to mouse Tfr cells or whether human Tfr cells consist of a variety of related follicular T cell populations that are distinct from mouse Tfr cells remains to be determined. Circulating Tfr cells have been examined extensively in humans (35,43,(46)(47)(48), however, the relationship of these cells to tissue-resident Tfr cells is not known. Much work remains to be done on human Tfr cells.…”

Section: Discussionmentioning

confidence: 99%

T follicular regulatory cells and IL-10 promote food antigen–specific IgE

Xie¹,

Chen²,

Liu³

et al. 2020

Journal of Clinical Investigation

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

T follicular regulatory cells and IL-10 promote food antigen–specific IgE

Xie¹,

Chen²,

Liu³

et al. 2020

Journal of Clinical Investigation

View full text Add to dashboard Cite

“…Of note, allergen-specific immunotherapy (AIT), which leads to improved prognosis in allergic patients, efficiently reduces circulating T FH cell levels (68,69). AIT treatment also markedly increases the frequency of T follicular regulatory (T FR ) cells, which are known to suppress the germinal center reaction (69,70).…”

Section: T Fh Cells In Human Asthmamentioning

confidence: 99%

T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma

2019

View full text Add to dashboard Cite

For many decades, T helper 2 (T H 2) cells have been considered to predominantly regulate the pathogenic manifestations of allergic asthma, such as IgE-mediated sensitization, airway hyperresponsiveness, and eosinophil infiltration. However, recent discoveries have significantly shifted our understanding of asthma from a simple T H 2 cell-dependent disease to a heterogeneous disease regulated by multiple T cell subsets, including T follicular helper (T FH ) cells. T FH cells, which are a specialized cell population that provides help to B cells, have attracted intensive attention in the past decade because of their crucial role in regulating antibody response in a broad range of diseases. In particular, T FH cells are essential for IgE antibody class-switching. In this review, we summarize the recent progress regarding the role of T FH cells and their signature cytokine interleukin (IL)-21 in asthma from mouse studies and clinical reports. We further discuss future therapeutic strategies to treat asthma by targeting T FH cells and IL-21.

show abstract

“…Although the emphasis of Tfr‐cell studies is mainly on AIDs, vaccine responses and other diseases including infections, cancers, allergies, chronic graft rejection/graft‐versus‐host disease (GVHD) and acute respiratory distress syndrome (ARDS) have also been under investigation (shown in Table ).…”

Section: Tfr Cells In Human Diseases and Animal Modelsmentioning

confidence: 99%

“…Frequencies of Tfr cells are found to be lower in peripheral blood from post‐transplant food allergy patients and in tonsils from allergic rhinitis (AR) patients . The phenotype and number of cTfr cells are correlated with tonsillar Tfr cells . Moreover, cTfr cells in AR patients show impaired function specifically in suppressing IgE expression rather than other immunoglobulin types.…”

Section: Tfr Cells In Human Diseases and Animal Modelsmentioning

confidence: 99%

“…The number and function of cTfr cells are negatively correlated with antigen‐specific IgE production and disease activity in AR patients. Once patients get relief after allergen immunotherapy, the frequency and function of cTfr cells are recovered . Tfr cells have also been investigated in a food allergy mouse model to measure peanut‐specific antibody responses …”

Section: Tfr Cells In Human Diseases and Animal Modelsmentioning

confidence: 99%

See 1 more Smart Citation

Follicular regulatory T cells: a novel target for immunotherapy?

et al. 2020

View full text Add to dashboard Cite

High‐affinity antibodies are produced during multiple processes in germinal centres (GCs), where follicular helper T (Tfh) cells interact closely with B cells to support B‐cell survival, differentiation and proliferation. Recent studies have revealed that a specialised subset of regulatory T cells, follicular regulatory T (Tfr) cells, especially fine‐tune Tfh cells and GC B cells, ultimately regulating GC reactions. Alterations in frequencies or function of Tfr cells may result in multiple autoantibody‐mediated or autoantibody‐associated diseases. This review discusses recent insights into the physiology and pathology of Tfr cells, with a special emphasis on their potential roles in human diseases. Discrepancies are common among studies, reflecting the limited understanding of Tfr cells. Further exploration of the mechanisms of Tfr cells in these diseases and thus targeting Tfr cells may help reinstate immune homeostasis and provide novel immunotherapy.

show abstract

Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis

Cited by 82 publications

References 42 publications

T follicular regulatory cells and IL-10 promote food antigen–specific IgE

T follicular regulatory cells and IL-10 promote food antigen–specific IgE

T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma

Follicular regulatory T cells: a novel target for immunotherapy?

Contact Info

Product

Resources

About