Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit

Dehdar, Kolsoum; Mahdidoust, Shirin; Salimi, Morteza; Gholami-Mahtaj, Leila; Nazari, Milad; Mohammadi, Sadeq; Dehghan, Samaneh; Jamaati, Hamidreza; Khosrowabadi, Reza; Nasiraei-Moghaddam, Abbas; Barkley, Victoria; Javan, Mohammad; Mirnajafi‐Zadeh, Javad; Sumiyoshi, Akira; Raoufy, Mohammad Reza

doi:10.1038/s41598-019-55539-3

Cited by 38 publications

(26 citation statements)

References 64 publications

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“…LFPs were simultaneously obtained from OB, EC, and dHPC via a fixed miniature buffer head stage with high-input impedance (BIODAC-A, TRITA Health Technology Co., Tehran, Iran). The signals were amplified using 1000 amplification gain, low-pass filtered < 250 Hz, and digitized at 1 kHz through a recording system (BIODAC-ESR18622, TRITA Health Technology Co., Tehran, Iran) 78 , 79 . EEG lab toolbox was applied for pre-processing the signals, including noise rejection and baseline correction 80 .…”

Section: Methodsmentioning

confidence: 99%

Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer’s disease model

Salimi

Tabasi

Abdolsamadi

et al. 2022

Sci Rep

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Neural synchrony in brain circuits is the mainstay of cognition, including memory processes. Alzheimer's disease (AD) is a progressive neurodegenerative disorder that disrupts neural synchrony in specific circuits, associated with memory dysfunction before a substantial neural loss. Recognition memory impairment is a prominent cognitive symptom in the early stages of AD. The entorhinal–hippocampal circuit is critically engaged in recognition memory and is known as one of the earliest circuits involved due to AD pathology. Notably, the olfactory bulb is closely connected with the entorhinal–hippocampal circuit and is suggested as one of the earliest regions affected by AD. Therefore, we recorded simultaneous local field potential from the olfactory bulb (OB), entorhinal cortex (EC), and dorsal hippocampus (dHPC) to explore the functional connectivity in the OB-EC-dHPC circuit during novel object recognition (NOR) task performance in a rat model of AD. Animals that received amyloid-beta (Aβ) showed a significant impairment in task performance and a marked reduction in OB survived cells. We revealed that Aβ reduced coherence and synchrony in the OB-EC-dHPC circuit at theta and gamma bands during NOR performance. Importantly, our results exhibit that disrupted functional connectivity in the OB-EC-dHPC circuit was correlated with impaired recognition memory induced by Aβ. These findings can elucidate dynamic changes in neural activities underlying AD, helping to find novel diagnostic and therapeutic targets.

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Section: Methodsmentioning

confidence: 99%

Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer’s disease model

Salimi

Tabasi

Abdolsamadi

et al. 2022

Sci Rep

Self Cite

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“…Our recent study demonstrated that LPS causes anxiety and depression-like behaviors accompanied by an enhanced activity of the dmPFC-BLA circuits [ 12 ]. In addition, allergic inflammation leads to enhanced functional connectivity within the mPFC-amygdala circuit, while disrupting the dynamic interactions of the mPFC-amygdala circuit may promote anxiety-related behaviors with asthma [ 151 ]. Furthermore, a recent study from the same lab showed that allergic inflammation induced an increase in neuronal activity, and functional connectivity of the ACC-BLA circuit was correlated with the level of anxiety [ 152 ].…”

Section: Amygdala Neuroinflammation and Psychiatric Disordersmentioning

confidence: 99%

New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder

Pan

et al. 2022

IJMS

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Depression and anxiety disorders are the two most prevalent psychiatric diseases that affect hundreds of millions of individuals worldwide. Understanding the etiology and related mechanisms is of great importance and might yield new therapeutic strategies to treat these diseases effectively. During the past decades, a growing number of studies have pointed out the importance of the stress-induced inflammatory response in the amygdala, a kernel region for processing emotional stimuli, as a potentially critical contributor to the pathophysiology of depression and anxiety disorders. In this review, we first summarized the recent progress from both animal and human studies toward understanding the causal link between stress-induced inflammation and depression and anxiety disorders, with particular emphasis on findings showing the effect of inflammation on the functional changes in neurons in the amygdala, at levels ranging from molecular signaling, cellular function, synaptic plasticity, and the neural circuit to behavior, as well as their contributions to the pathology of inflammation-related depression and anxiety disorders. Finally, we concluded by discussing some of the difficulties surrounding the current research and propose some issues worth future study in this field.

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“…MPFC is activated by strong emotions (71). In addition, Dehdar et al (72) found that the prefrontal lobe of patients with asthma is related to the regulation of anxiety. This suggests that there may be a relationship between the function of respiration and the functional changes of MPFC in different emotional states.…”

Section: Discussionmentioning

confidence: 99%

Asthma's effect on brain connectivity and cognitive decline

2023

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ObjectiveTo investigate the changes in dynamic voxel mirror homotopy connection (dVMHC) between cerebral hemispheres in patients with asthma.MethodsOur study was designed using a case-control method. A total of 31 subjects with BA and 31 healthy subjects with matching basic information were examined using rsfMRI. We also calculated and obtained the dVMHC value between the cerebral cortexes.ResultsCompared with the normal control group, the dVMHC of the lingual gyrus (Ling) and the calcarine sulcus (CAL), which represented the visual network (VN), increased significantly in the asthma group, while the dVMHC of the medial superior frontal gyrus (MSFG), the anterior/middle/posterior cingulate gyrus (A/M/PCG), and the supplementary motor area (SMA) of the sensorimotor network decreased significantly in the asthma group.ConclusionThis study showed that the ability of emotion regulation and the efficiency of visual and cognitive information processing in patients with BA was lower than in those in the HC group. The dVMHC analysis can be used to sensitively evaluate oxygen saturation, visual function changes, and attention bias caused by emotional disorders in patients with asthma, as well as to predict airway hyperresponsiveness, inflammatory progression, and dyspnea.

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Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit

Cited by 38 publications

References 64 publications

Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer’s disease model

Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer’s disease model

New Insights into the Pivotal Role of the Amygdala in Inflammation-Related Depression and Anxiety Disorder

Asthma's effect on brain connectivity and cognitive decline

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