Allergen-specific exposure associated with high immunoglobulin E and eye rubbing predisposes to progression of keratoconus

Shetty, Rohit; Sureka, Shraddha; Kusumgar, Pallak; Sethu, Swaminathan; Sainani, Kanchan

doi:10.4103/ijo.ijo_217_17

Cited by 22 publications

(18 citation statements)

References 13 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A significant correlation between KC progression with hormonal changes, as in pregnancy, lactation and thyroid eye disease,3,4 was elucidated in the literature 5. Vernal keratoconjunctivitis (VKC), chronic eye rubbing, dry eye disease and limbal stem cell inefficacy have been reported as aggressive factors that both promote KC progression and treatment failure especially in pediatric patients 6,7…”

Section: Introductionmentioning

confidence: 99%

<p>Visual and Refractive Long-Term Outcomes Following Standard Cross-Linking in Progressive Keratoconus Management</p>

Iqbal¹,

Elmassry²,

Badawi³

et al. 2019

OPTH

View full text Add to dashboard Cite

PurposeTo analyze the effectiveness and stability of the refractive, topographic and visual outcomes of the standard cross-linking (SCXL) in keratoconus (KC) management.Patients and methodsThis study was designed as a retrospective non-comparative study that included 28 KC patients (n=49 eyes) who performed SCXL as a single procedure to treat KC and completed five-year follow-up period. The topographic, refractive and visual data were recorded preoperatively and at 12, 24, 36 and 60 months postoperatively.ResultsForty eyes (81.6%) showed achieved postoperative spherical equivalent (SE) refraction better than the attempted refraction. Ten eyes (20.4%) improved by <1 D, 23 eyes (46.9%) improved from 1 D to <2 D and 7 eyes (14.3%) improved by ≥2 D. Both uncorrected distant visual acuity (UDVA) and corrected distant visual acuity (CDVA) showed statistically significant improvement from preoperative 1.34±0.29 (mean±SD) and 0.74±0.23 LogMAR to postoperative 0.99±0.32 and 0.50±0.22 LogMAR (P<0.0001) respectively. Both Kmax and SE refraction showed statistically significant and stable improvement from preoperative 51.95±1.90 and −7.90±3.14 D to postoperative 50.19±1.96 and −6.35±2.49 D (P<0.0001) respectively. Two eyes (4%) showed KC progression at the end of 5th follow-up year.ConclusionSCXL had good effectiveness and stability that halted KC progression over 5-year follow-up period. It had also unexpected improvement in the KC refractive components mainly the spherical and SE components.

show abstract

Section: Introductionmentioning

confidence: 99%

<p>Visual and Refractive Long-Term Outcomes Following Standard Cross-Linking in Progressive Keratoconus Management</p>

Iqbal¹,

Elmassry²,

Badawi³

et al. 2019

OPTH

View full text Add to dashboard Cite

show abstract

“…Nonsurgical management of KC should include verbal guidance to avoid eye rubbing, use of topical anti-allergic medication in patients with allergy, and use of lubricants for ocular irritation [ 3 ]. In early cases, control of the allergic reaction to decrease the eye rubbing impulse may reduce the inflammation and help avoid corneal complications [ 28 ]. Salomao et al [ 29 ] stress the need for screening; though moderate and advanced cases of keratoconus are easily recognized, identification of mild and early forms of keratoconus remains a challenge.…”

Section: Discussionmentioning

confidence: 99%

A Case of Early Keratoconus Associated with Eye Rubbing in a Young Child

Dimacali

Balidis²,

Adamopoulou³

et al. 2020

Ophthalmol Ther

View full text Add to dashboard Cite

Introduction: Keratoconus usually presents during puberty and is considered rare in young children. Methods: Case report with clinical findings and computerized corneal tomography. Results: We report the case of an 8-year-old girl with early bilateral keratoconus who presented with allergic conjunctivitis and persistent eye rubbing. Although our patient did not exhibit steep keratometry, early cones and inferotemporal thinnest corneal thicknesses were detected in both eyes using Scheimpflug imaging (Oculus GmbH Pentacam, Wetzlar, Germany). Belin/Ambró sio total D values were 1.85 on the right and 2.11 on the left. Improvement in best-corrected visual acuity was noted after treatment of allergic eye disease, and corneal tomographic findings remained stable 4 months after initial consult. Conclusion: This is a case of early diagnosed keratoconus in a young patient. Diagnosis of this condition in young children is challenging, as these patients are less likely to report visual complaints, and clinical examination is usually unremarkable. Keratoconus screening should be considered in children with atopy and eye rubbing behavior regardless of age, even in those with no other associated pathology and with negative family history.

show abstract

“…[9–11] However, some investigations have indicated that the eye rubbing itself may play a crucial role in the development of corneal ectasia in keratoconus. [6,7,11,12] Accidental or self-induced ocular injuries may also cause keratoconus, with 3 reports demonstrating an association between keratoconus and TS. [13–15]…”

Section: Introductionmentioning

confidence: 99%

Corneal cross-linking for keratoconus caused by compulsive eye rubbing in patients with Tourette syndrome

et al. 2019

View full text Add to dashboard Cite

Rationale: Eye rubbing is an important risk factor for keratoconus progression. Tourette syndrome (TS) is a neurological disorder, and approximately 50% of individuals with TS exhibit obsessive-compulsive behaviors including eye rubbing. We report the effects of corneal cross-linking (CXL) on the progression of keratoconus combined with psychiatric treatment for 3 patients with TS. Patients’ concerns: Three cases, 24-year-old male, 14-year-old male, and 17-year-old male, were all referred to our institute, due to decreased visual acuity. Diagnosis: All 3 patients were diagnosed with progressive keratoconus. They were found to rub their eyes, and were also diagnosed with TS by psychiatrists. Intervention: Upon diagnosis of keratoconus, we performed CXL on 1 eye of each patient. Outcomes: After CXL, there was no further progression. Psychiatric medication was also required. Lessons: For patients with keratoconus caused by eye rubbing due to TS, CXL seems to be effective when done in association with psychiatric treatment.

show abstract

Allergen-specific exposure associated with high immunoglobulin E and eye rubbing predisposes to progression of keratoconus

Cited by 22 publications

References 13 publications

<p>Visual and Refractive Long-Term Outcomes Following Standard Cross-Linking in Progressive Keratoconus Management</p>

<p>Visual and Refractive Long-Term Outcomes Following Standard Cross-Linking in Progressive Keratoconus Management</p>

A Case of Early Keratoconus Associated with Eye Rubbing in a Young Child

Corneal cross-linking for keratoconus caused by compulsive eye rubbing in patients with Tourette syndrome

Contact Info

Product

Resources

About