Allergen-specific immunotherapy in allergic rhinitis

Klimov, Vladimir V.; Koshkarova, N. S.; Sviridova, V. S.; Klimov, Andrew

doi:10.20538/1682-0363-2022-2-168-174

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…Иммунотерапия также имеет ряд недостатков: длительность лечения, высокую стоимость, недостаточную комплаентность, аллергенспецифичность иммунотерапии [5]. Аллергенспецифическая иммунотерапия (АСИТ) противопоказана при рецидивах атопических болезней, неконтролируемой тяжелой астме, тяжелых кардиоваскулярных расстройствах, психозах, злокачественных опухолях, тяжелых системных аутоиммунных болезнях, беременности в начале иммунотерапии и острых инфекциях [24]. Применение АСИТ затруднено при развитии полисенсибилизации [22].…”

Section: обзоры и лекции Reviews and Lecturesunclassified

Prospects for the Use of Mesenchymal Stem Cells of the Olfactory Laying in the Treatment of Allergic Rhinitis and Chronic Polyposis Rhinosinusitis: A Literature Review

Шулепова,

Ниделько,

Мантивода

et al. 2023

Оториноларингология. Восточная Европа

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В статье представлен обзор литературы, основанный на поисковых базах Medline, Embase, PubMed, научной электронной библиотеке eLibrary, с момента их создания до 31 мая 2023 г. Клеточные технологии являются перспективными в лечении хронических неинфекционных заболеваний полости носа, таких как аллергический ринит и хронический полипозный риносинусит. Использование терапии на основе мезенхимальных стволовых клеток приводит к снижению продукции провоспалительных цитокинов, подавлению иммунного воспаления и стимуляции регенерации тканей в месте их введения. Мезенхимальные стволовые клетки способны распознавать поврежденный участок и индуцировать иммунный ответ как врожденного, так и адаптивного иммунитета в случае недостаточного иммунного ответа. С другой стороны, они подавляют функцию иммунных клеток, если в поврежденном участке формируется избыточная иммунная реакция. Таким образом, в зависимости от уровня секреции факторов воспалительной среды мезенхимальные стволовые клетки проявляют либо провоспалительную, либо противовоспалительную функцию. Дальнейшее изучение иммунных процессов при хронических неинфекционных заболеваниях полости носа будет способствовать появлению новых, более эффективных методов лечения, основанных на клеточной терапии. The article presents a literature review based on the Medline, Embase, Pubmed search databases, eLibrary scientific electronic library from the moment of their creation until May 31, 2023. Cellular technologies are promising in the treatment of chronic non- communicable diseases of the nasal cavity such as allergic rhinitis and chronic polypous rhinosinusitis. The use of mesenchymal stem cells leads to a decrease in the production of pro-inflammatory cytokines, suppresses immune inflammation and stimulates tissue regeneration at the injection site. Mesenchymal stem cells are capable of recognizing a damaged site and inducing an immune response of both innate and adaptive immunity in case of an insufficient immune response. On the other hand, they suppress the function of immune cells if an excessive immune response forms in the damaged area. Thus, depending on the level of secretion of inflammatory environment factors, mesenchymal stem cells exhibit either pro-inflammatory or anti-inflammatory functions. Further study of immune processes in chronic non-communicable diseases of the nasal cavity will contribute to the emergence of new, more effective methods of treatment based on cell therapy.

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Section: обзоры и лекции Reviews and Lecturesunclassified

Prospects for the Use of Mesenchymal Stem Cells of the Olfactory Laying in the Treatment of Allergic Rhinitis and Chronic Polyposis Rhinosinusitis: A Literature Review

Шулепова,

Ниделько,

Мантивода

et al. 2023

Оториноларингология. Восточная Европа

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Features of the course of pollen allergy in children in the Nizhny Novgorod region

Baskakova,

Tarasova,

Savichev

et al. 2024

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Due to its widespread distribution, the problem of pollen allergy does not lose its relevance for practical healthcare: the variety of clinical forms, the possibility of polyvalent sensitization and pathogenetic treatment in the form of allergen-specific immunotherapy determine the importance of studying its clinical and epidemiological features.Materials and methods. A retrospective analysis of 119 discharge summaries of children with diagnoses of “Allergic rhinoconjunctivitis”, “Bronchial asthma”, “Atopic dermatitis”, occurring with clinically significant pollen sensitization, was carried out in the period 2015–2022. The prevalence, clinical features, prevailing symptoms and atopic comorbidity of patients with pollen allergy living in the Nizhny Novgorod region were assessed.Results. Pollen allergy is characterized by a variety of clinical manifestations, which are mainly represented by allergic rhinoconjunctivitis, bronchial asthma, and oral allergic syndrome. In the study, in the majority of patients, polyvalent sensitization was combined with a pronounced variety of products that provoke oral allergic syndrome. Manifestations of pollen allergies requiring seeking medical help are equally distributed among residents of Nizhny Novgorod and the region’s villages.Conclusions. Clinical and epidemiological features of the course of pollen allergy are of great interest to the practicing physician. The variety of manifestations of pollen allergies determines the need for a clinically effective treatment method, which today is ASIT. One of the needs of modern healthcare is to increase the awareness of primary care physicians about atopic diseases, incl. pollen allergy, with the aim of timely referral of patients to a specialist. Currently, allergen-specific immunotherapy is the most effective method of treating manifestations of pollen allergies.

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Allergen-specific immunotherapy in allergic rhinitis

Cited by 2 publications

References 57 publications

Prospects for the Use of Mesenchymal Stem Cells of the Olfactory Laying in the Treatment of Allergic Rhinitis and Chronic Polyposis Rhinosinusitis: A Literature Review

Prospects for the Use of Mesenchymal Stem Cells of the Olfactory Laying in the Treatment of Allergic Rhinitis and Chronic Polyposis Rhinosinusitis: A Literature Review

Features of the course of pollen allergy in children in the Nizhny Novgorod region

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