Allergen-specific Immunotherapy in Atopic Eczema

Darsow, Ulf; Forer, I.; Ring, Johannes

doi:10.1007/s11882-011-0194-7

Cited by 30 publications

(29 citation statements)

References 45 publications

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“…84 Although nonrespiratory allergic symptoms are beyond the scope of this review, it is worth noting that sensitization can be both systemic and localized. Inhalation of HDM aeroallergens can elicit eczematous lesions, 85,86 and patients with nonsteroidal anti-inflammatory drug-induced urticaria/angioedema show a high prevalence of HDM sensitization. 87 This suggests that deposition of an allergen in one organ (the respiratory tract) causes symptom flare-ups in another organ.…”

Section: Upper and Lower Airways: The Relationship In Hdm Allergymentioning

confidence: 99%

Respiratory allergy caused by house dust mites: What do we really know?

Calderón

Linneberg

Kleine-Tebbe³

et al. 2015

Journal of Allergy and Clinical Immunology

433

309

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The house dust mite (HDM) is a major perennial allergen source and a significant cause of allergic rhinitis and allergic asthma. However, awareness of the condition remains generally low. This review assesses the links between exposure to HDM, development of the allergic response, and pathologic consequences in patients with respiratory allergic diseases. We investigate the epidemiology of HDM allergy to explore the interaction between mites and human subjects at the population, individual, and molecular levels. Core and recent publications were identified by using "house dust mite" as a key search term to evaluate the current knowledge of HDM epidemiology and pathophysiology. Prevalence data for HDM allergen sensitization vary from 65 to 130 million persons in the general population worldwide to as many as 50% among asthmatic patients. Heterogeneity of populations, terminology, and end points in the literature confound estimates, indicating the need for greater standardization in epidemiologic research. Exposure to allergens depends on multiple ecological strata, including climate and mite microhabitats within the domestic environment, with the latter providing opportunity for intervention measures to reduce allergen load. Inhaled mite aeroallergens are unusually virulent: they are able to activate both the adaptive and innate immune responses, potentially offering new avenues for intervention. The role of HDM allergens is crucial in the development of allergic rhinitis and asthma, but the translation of silent sensitization into symptomatic disease is still incompletely understood. Improved understanding of HDMs, their allergens, and their microhabitats will enable development of more effective outcomes for patients with HDM allergy.

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Section: Upper and Lower Airways: The Relationship In Hdm Allergymentioning

confidence: 99%

Respiratory allergy caused by house dust mites: What do we really know?

Calderón

Linneberg

Kleine-Tebbe³

et al. 2015

Journal of Allergy and Clinical Immunology

433

309

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“…Atopic dermatitis shows a genetic predisposition, multiple changes in immune functions, environmental interaction and a reduced skin barrier function resulting in facilitated contact of allergens with cells of the immune system [1]. The mechanisms of HDM involved in AD development are not well understood.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of sublingual immunotherapy with Dermatophagoides farinae vaccine in a murine atopic dermatitis model

Liu

Guo

Liang

et al. 2015

Clin Experimental Allergy

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“…The efficacy of specific immunotherapy in AD has been shown in a number of case reports and smaller cohort studies,[23] and, more recently, in a larger multicenter trial with subcutaneous house dust mite immunotherapy. [24] Allergen Specific Immunotherapy (ASIT) may have positive effects in selected, highly sensitized patients with AE.…”

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confidence: 99%