Allergen‐specific immunotherapy in horses with insect bite hypersensitivity: a double‐blind, randomized, placebo‐controlled study

Ginel, Pedro J.; Hernández, Eduardo; Lucena, R.; Blanco, B.; Novales, M.; Mozos, E.

doi:10.1111/vde.12092

Cited by 40 publications

(35 citation statements)

References 18 publications

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“…This has also been tried in IBH-affected horses using whole body extract of Culicoides, with contradictory results (Anderson et al, 1996;Barbet et al, 1990;Ginel et al, 2014). Whole body Culicoides extract can be expected to contain various substances not relevant for IBH, and therefore it is difficult to determine the dosage and frequency of injections needed to standardize the treatment.…”

Section: Discussionmentioning

confidence: 96%

Developing a preventive immunization approach against insect bite hypersensitivity using recombinant allergens: A pilot study

Jónsdóttir

Hamza

Janda

et al. 2015

Veterinary Immunology and Immunopathology

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Section: Discussionmentioning

confidence: 96%

Developing a preventive immunization approach against insect bite hypersensitivity using recombinant allergens: A pilot study

Jónsdóttir

Hamza

Janda

et al. 2015

Veterinary Immunology and Immunopathology

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“…To date, none of the attempts at allergen specific immunotherapy for IBH have been successful (123)(124)(125), although as all of these studies used a crude nonstandardized extract of whole midges this is unsurprising. If allergen immunotherapy is to be successful, current scientific knowledge would indicate that it will have to stimulate regulatory T cells specific for the allergens in midge saliva.…”

Section: Immunotherapymentioning

confidence: 94%

Immune responses to ectoparasites of horses, with a focus on insect bite hypersensitivity

Wilson

2014

Parasite Immunology

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Horses are affected by a wide variety of arthropod ectoparasites, ranging from lice which spend their entire life on the host, through ticks which feed over a period of days, to numerous biting insects that only transiently visit the host to feed. The presence of ectoparasites elicits a number of host responses including innate inflammatory responses, adaptive immune reactions and altered behaviour; all of which can reduce the severity of the parasite burden. All of these different responses are linked through immune mechanisms mediated by mast cells and IgE antibodies which have an important role in host resistance to ectoparasites, yet immune responses also cause severe pathological reactions. One of the best described examples of such pathological sequelae is insect bite hypersensitivity (IBH) of horses; an IgE-mediated type 1 hypersensitivity to the salivary proteins of Culicoides spp. associated with T-helper-2 production of IL4 and IL13. Importantly, all horses exposed to Culicoides have an expanded population of Culicoides antigen-specific T cells with this pattern of cytokine production, but in those which remain healthy, the inflammatory reaction is tempered by the presence of FoxP3+ CD4+ regulatory T cells that express IL10 and TGF-beta, which suppresses the IL4 production by Culicoides antigen-activated T cells.

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“…In this study, Pedro Ginel and colleagues in Spain evaluated the efficacy of allergen‐specific immunotherapy (ASIT) in horses with insect bite hypersensitivity using commercially available extracts and tests.…”

Section: Allergen‐specific Immunotherapy In Horsesmentioning

confidence: 99%

Highlights of recent clinically relevant papers

Wright¹

2014

Equine Veterinary Education

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Allergen‐specific immunotherapy in horses with insect bite hypersensitivity: a double‐blind, randomized, placebo‐controlled study

Abstract: Using commercially available extracts and tests, we could not demonstrate a beneficial effect of 1 year multiple ASIT in nonstabled horses with IBH.

Cited by 40 publications

References 18 publications

Developing a preventive immunization approach against insect bite hypersensitivity using recombinant allergens: A pilot study

Developing a preventive immunization approach against insect bite hypersensitivity using recombinant allergens: A pilot study

Immune responses to ectoparasites of horses, with a focus on insect bite hypersensitivity

Highlights of recent clinically relevant papers

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