Allergenic and antigenic relationship between three species of storage mite and the house dust mite,

Griffin, Peter; Ford, Anna; Alterman, Lesley A.; Thompson, Janice; Parkinson, C. L.; Blainey, A. D.; Davies, Robert J.; Topping, M. D.

doi:10.1016/0091-6749(89)90184-x

Cited by 60 publications

(47 citation statements)

References 22 publications

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“…has been reported by some authors [7, 11, 26, 27, 28], but others have demonstrated some cross–reactivity [29, 30]. Moreover, up to 47% inhibition of D. siboney whole extract was achieved by Blomia extract [18] and up till 38% of inhibition of IgE binding to individual allergens was observed in this paper.…”

Section: Discussionsupporting

confidence: 52%

“…Understanding of the cross–reactivity between prevalent mite species is essential to settle appropriate strategies for diagnosis and immunotherapy. Cross–reactivity between allergens from mites of the genus Dermatophagoides [2, 3, 4, 5] and between allergens from less taxonomically related mites [6, 7, 8, 9, 10, 11, 12, 13] has been reported. Moreover, intra–species cross–reactivity between different major allergens has been demonstrated within the genus Dermatophagoides [14].…”

Section: Introductionmentioning

confidence: 99%

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Cross–Reactivity between Dermatophagoides siboney and Other Domestic Mites

Ferrándiz

Casas²,

Dreborg³

1998

Int Arch Allergy Immunol

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Background: Dermatophagoides siboney (Ds) cross–reacted with other mite allergens in mite–allergic patients. The aim of this study was to investigate the cross–reactivity between individual allergens responsible for this cross–reactivity. Methods: The inhibition of IgE binding to Ds allergens was investigated by non–reducing SDS–PAGE and Western blotting. Nitrocellulose membranes were incubated with a pool of sera from mite–sensitive asthmatics, after the addition of serial dilutions of D. farinae (Df), D. pteronyssinus (Dp), D. microceras (Dm), Lepidoglyphus destructor (Ld), Tyrophagus putrescentiae (Tp), Acarus siro (As) and Blomia tropicalis (Bt). N–terminal amino acid sequences and amino acid analysis of the purified major allergens, Der s 1, 2 and 3, were performed after transfer to polyvinylidene difluoride membranes. Results: The inhibition was higher with Df (86%), Dp (54%) and Dm (49%) extracts than with Ld (20%), Tp (11%), As (18%) and Bt (6%). The dose–response inhibition showed a diverse pattern for the individual allergens. Despite the high cross–reactivity between the pyroglyphid mites, some proteins of Ds were less inhibited, e.g. by the Df and Dp 80–kD protein, and by the Dm and Dp 52–, 37–, 30– and 14–kD allergens. The 65–, 62–, 37– and 30–kD proteins were always inhibited more than 50% by all the mite extracts at the maximum concentration used. The 80–, 52–, 43–, 27– and 14–kD proteins cross–reacted to a lesser extent. Individual allergens of Ds were much less inhibited by non–pyroglyphid mites. However, at the highest concentration, Ld also inhibited most of the Ds allergens. All the ten selected allergens were inhibited to some extent by the heterologous mite extracts. The N–terminal sequences of Der s 1, 2 and 3 allergens showed higher homology to Df and Dm than to Dp. The homology of the group 2 allergens was higher than that of the group 1 allergens. Conclusion: The individual allergens of Ds were more similar to Df and Dm than to Dp. There was a limited and variable cross–reactivity with non–pyroglyphid mites. No single allergen was unique for Ds.

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Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Cross–Reactivity between Dermatophagoides siboney and Other Domestic Mites

Ferrándiz

Casas²,

Dreborg³

1998

Int Arch Allergy Immunol

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“…Second, a positive skin reaction to house dust mites may reflect cross-reactivity to CRM. There is an agreement in the suggestion that the closer the taxonomic relationship between the mites is, the greater the level of cross-allergenicity is [25][26][27]. CRM belongs to the order of mites (Acari), to the suborder of Prostigmata, to the family of spider mites (Tetranychidae), to the genus Panonychus and represents its own species.…”

Section: Discussionmentioning

confidence: 75%

Citrus red mite (Panonychus citri) is the most common sensitizing allergen of asthma and rhinitis in citrus farmers

Kim

Son

Kim

et al. 1999

Clin Experimental Allergy

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SummaryObjective To evaluate type I hypersensitivity to citrus red mite (Panonychus citri), its prevalence, and relationship to respiratory dysfunction, a cross-sectional survey was performed among citrus farmers on Cheju Island, Korea. Materials and methods Questionnaires, and skin prick test responses to 11 common inhalant allergens and citrus red mite were performed in 181 citrus farmers, and serumspecific IgE antibodies to citrus red mite were measured by ELISA in sera of 123 subjects. To determine airway hyperresponsiveness, methacholine bronchial provocation tests were performed in 55 subjects who complained of recurrent lower respiratory symptoms. Results The prevalence of asthma-based on presence of asthmatic symptoms on the questionnaire and airway hyperresponsiveness to methacholine, and allergic rhinitis based on presence of nasal symptoms on the questionnaire and positive skin-test response were 12.1% and 19.3%, respectively. The positive rate of skin responses to one or more of 11 common inhalant allergens excluding citrus red mite was 17.1%, and if citrus red mite was included, 25.9% of farmers had positive responses. On skin prick tests, citrus red mite (16.5%) was the most common sensitizing allergen, followed by cockroach (11.0%), Dermatophagoides pteronyssinus (9.9%), and D. farinae (9.3%). Among farmers with asthma and allergic rhinitis, the positive skin responses to citrus red mite were noted in 54.5 and 68.5%, respectively. Serum-specific IgE antibodies to citrus red mite were detected in 45 farmers (36.5%) of the 123 tested, and there was significant correlation between specific IgE level and weal (A/H ratio) to citrus red mite (r ¼ 0.57, P < 0.001). The prevalence of asthma was higher in subjects with positive skin responses or high serum-specific IgE antibodies to citrus red mite than in those without skin response or serum specific IgE (P < 0.05, respectively). Conclusion Citrus red mite is the most important allergen in citrus farmers with asthma and rhinitis in which causative allergen has not been identified. It should be included in the skin test battery for screening the causative allergen in farmers exposed to citrus red mite.

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“…Results from CIE/CRIE indicate that HDM and T. putrescentiae have two similar allergens (79), and that HDM and A. siro have one (76). A 25-kDa component is responsible for the cross-reactivity between HDM and A. siro/T.…”

Section: Storage Mitesmentioning

confidence: 99%

“…HDM seem to cross-react more strongly to A. siro and T. putrescentiae than to L. destructor (61). Generally, HDM are stronger inhibitors of A. siro/ T. putrescentiae-speci®c IgE-binding than vice versa (61,62,74,76). L. destructor extract may show stronger inhibition of HDM allergens than vice versa (77); similarly, HDM extract seems to be a weak inhibitor of the binding of anti-L d mAbs to L. destructor antigen (78).…”

Section: Storage Mitesmentioning

confidence: 99%