Allergenic extracts to diagnose and treat sensitivity to insect venoms and inhaled allergens

Khurana, Taruna; Bridgewater, Jennifer; Rabin, Ronald L.

doi:10.1016/j.anai.2016.05.026

Cited by 9 publications

(5 citation statements)

References 55 publications

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“…Besides cockroaches, other insects, including moths, mosquitoes, butterflies, and silkworms, are known to cause inhalational sensitization in humans. 22,23 Some…”

Section: Discussionmentioning

confidence: 99%

“…Besides cockroaches, other insects, including moths, mosquitoes, butterflies, and silkworms, are known to cause inhalational sensitization in humans 22,23 . Some feeding insects, such as mosquitoes, can precipitate asthma, 24 but bed bugs are rarely reported to cause bronchospasm, asthma, or anaphylaxis 19,25–27 .…”

Section: Discussionmentioning

confidence: 99%

“…Besides cockroaches, other insects, including moths, mosquitoes, butterflies, and silkworms, are known to cause inhalational sensitization in humans. 22 , 23 Some feeding insects, such as mosquitoes, can precipitate asthma, 24 but bed bugs are rarely reported to cause bronchospasm, asthma, or anaphylaxis. 19 , 25 , 26 , 27 In a study in Egypt, C. lectularius extract caused positive skin reactions in a higher percentage of patients with asthma (37%–50%) compared with patients without asthma (9%–18%).…”

Section: Discussionmentioning

confidence: 99%

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Respiratory diseases in patients with bed bugs

Sheele

2021

Clinical Respiratory J

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Introduction: Some arthropods such as cockroaches can exacerbate asthma, but it is unknown is this is true of bed bugs. Objectives: The objective of this work is to determine if bronchospastic diseases like asthma and chronic obstructive pulmonary disease (COPD) would be higher for ED patients who have bed bug infestation compared with patients who do not have bed bug infestation.Methods: A case-control study was performed with 332 adult emergency department (ED) patients with bed bug infestation and 4952 without infestation. Univariable and multivariable regression analysis was performed. Results and Conclusion:Patients with bed bug infestation were not more likely to have a past history of or an ED diagnosis of asthma or chronic obstructive pulmonary disease (COPD). However, bed bug infested patients were significantly more likely to undergo chest radiography, be admitted to the hospital, and receive albuterol in the ED (P < 0.05). Infested patients receiving albuterol in the ED were more likely to be admitted to the hospital compared with uninfested patients receiving albuterol (P < 0.001). Patients with an ED or inpatient diagnosis of asthma or COPD and bed bugs (compared with those without bed bugs) had significantly more ED visits during the study (P < 0.03). Bed bug infestations may be associated with respiratory pathology, which requires further investigation.

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“…Besides cockroaches, other insects, including moths, mosquitoes, butterflies, and silkworms, are known to cause inhalational sensitization in humans. 22,23 Some…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Respiratory diseases in patients with bed bugs

Sheele

2021

Clinical Respiratory J

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“…Fire ant venom is known as solenopsin, an alkaloid that burns and induces local erythema and the formation of pustules. Potent allergens in fire ant venoms are listed in Table 3 [71]. Imported fire ant venoms are crossreactive with other Hymenoptera venoms; e.g., the Sol i 1 allergen from S. invicta has cross-reactivity with yellow jacket phospholipase.…”

Section: Formicidae (Ants)mentioning

confidence: 99%

Emerging and Novel Elicitors of Anaphylaxis: Collegium Internationale Allergologicum Update 2024

Treudler

2024

Int Arch Allergy Immunol

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Background: Anaphylaxis represents the most severe end of the spectrum of allergic reactions. Frequent elicitors of anaphylaxis are insects, foods, and drugs. This paper summarizes recent development with regard to emerging and novel elicitors of anaphylaxis. Summary: Food allergens on the rise include pulses (like pea, chickpea), seeds (hemp, chia), nuts (cashew), pseudograins (buckwheat, quinoa), fruits, and microalgae. Novel foods are foods that were not consumed to any significant extent in the European Union before May 1997, which includes four edible insects (mealworm, migratory locust, house cricket, and buffalo worm). Recent investigations have pointed out the risk of anaphylaxis associated with the consumption of yellow mealworm for people allergic to shellfish and house dust mites. In Europe, fire ants (mostly Solenopsis invicta) and Vespa velutina nigrithorax represent invasive species, which account for increasing numbers of anaphylactic reactions. Also, several new drugs, especially biologicals, have been associated with anaphylaxis. Key Messages: Elicitors of anaphylaxis are changing as a result of (i) increase in demand for plant-based food, (ii) introduction of novel foods, (iii) spreading of allergens by climate changes and globalization, or (iv) due to exposure to newly developed drugs.

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“…Nevertheless, diagnosing mosquito allergy remains challenging. Skin prick reagents commercially used for diagnosing mosquito allergy contain whole body parts of mosquito and small concentrations of allergenic saliva proteins [49]. To date, no robust studies could prove the effect of desensitization with wholebody extract in treating mosquito allergic patients.…”

Section: Culicidae-mosquitoesmentioning

confidence: 99%

Part I: Insect stings and bites—Beyond the realm of bee and wasp allergies

et al. 2022

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Summary Background Insects are a very diverse group of animals and valuable members of any ecosystem. Allergies to bees and wasps (order: Hymenoptera) are well known in Europe. Allergies, toxicities, and the spread of diseases by other insects are also possible but quite frequently are not diagnosed. Sources A MEDLINE search on allergy caused by stinging and biting insects apart from bees and wasps was conducted. All relevant articles were evaluated, and a selection of relevant publications and cases from our outpatient units are used to illustrate our arguments. Content and implications Allergies to insects following bites and stings are common. Ant stings, mainly from imported fire ants, frequently lead to severe anaphylaxis, and their venom can elicit systemic toxic effects. Stings and bites of various other ant species can also lead to severe allergic reactions. Mosquito stings and horsefly or other Diptera stings may elicit severe local and IgE-mediated systemic reactions. True bugs (Hemiptera) are hematophagous insects and can also cause severe allergic reactions, in addition to being feared for transmitting diseases.

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Allergenic extracts to diagnose and treat sensitivity to insect venoms and inhaled allergens

Cited by 9 publications

References 55 publications

Respiratory diseases in patients with bed bugs

Respiratory diseases in patients with bed bugs

Emerging and Novel Elicitors of Anaphylaxis: Collegium Internationale Allergologicum Update 2024

Part I: Insect stings and bites—Beyond the realm of bee and wasp allergies

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