Allergenicity to Cannabis sativa L. and Methods to Assess Personal Exposure

Occupational Allergies to Cannabis

“…53 Investigations of adult nonmedical cannabis allergies have found type I hypersensitivity mechanisms involving allergen-specific IgE antibodies are predominant. 38,39,42,54 A growing number of studies have identified putative allergens from cannabis (Table 2), with nsLTP (Can s 3) as a major allergen, and oxygen evolving enhancing protein 2 ((OEEP2; Can s 4) as a relatively minor allergen. 39,41,42,47,55,56 Can s 3, the major cannabis allergen has been proposed as the driver of plant-food cross-reactivities observed in cannabis allergy in Europe (but not in U.S.) 38,41 .…”

“…This is primarily due to the high degree of similarities between the different nsLTP proteins in the plant kingdom and a sequence of conserved amino acid sequences in the C-terminal region of the mature protein. 54,57 It is important to emphasize that these cannabis allergens were primarily identified, and subsequently validated, in adult nonmedical users. In contrast, sensitization to nsLTP did not appear to be responsible for symptoms from cannabis exposures in law enforcement officers.…”

Occupational health and safety in cannabis production: an Australian perspective

“…Type 1 IgE hypersensitivy to cannabis may be on the increase [59], and cannabis pollen is considered as a potential allergen of public health significance [45,48,60]. The pollen, oils and leaves, can induce immune-mediated responses including allergic rhinitis, contact urticaria, allergic conjunctivitis, bronchial asthma, and angioedema [59,61]. The pollen release is seasonal, mainly during summer and autumn, coinciding with that of other local seasonal pollens such as grasses including rye grass, gumtrees, and acacias (wattle).…”

“…There is anecdotal evidence of allergic responses from contact to cannabis by law enforcement personnel [66]. Workers, who handle cannabis, particularly naïve atopic workers with no previous exposure or individuals sensitizsed to other allergens including fungi, may have an increased risk of hypersensitivity reactions [61]. Seed dust and aerosolised plant material may be a health concern in feed and oil production, fibre processing, biofuel or construction industries.…”

Analysis of the individual variability of hemp (Cannabis sativa L.) cultivars using SSR and SCAR markers

“…Основной ареал произрастания конопли посевнойзоны умеренного климата [1]. Поэтому, при наличии разрешения на возделывание этой культуры в рамках национальных законодательств, в России, Казахстане, Украине, странах Евросоюза, США и Китае отмечается постепенное возрождение отрасли коноплеводства.…”