Allergens and the Genetics of Allergy

Marsh, David G.

doi:10.1016/b978-0-12-635503-1.50011-5

Cited by 170 publications

(112 citation statements)

References 214 publications

Supporting

Mentioning

104

Contrasting

Unclassified

Order By: Relevance

“…6 Cada indivíduo atópico apresenta um "marcador" alérgi-co, manifestado por hiperreatividade somente a certos antí-genos e determinado primariamente por fatores genéticos e exposição ambiental. 7,8 A resposta não se limita à síntese de IgE, incluindo IgG e IgA específicas, assim como respostas …”

unclassified

Atopic diseases in Brazilian children - Etiologic multicentric study

Rizzo¹,

Solé²,

Rizzo³

et al. 1995

J Pediatr (Rio J)

View full text Add to dashboard Cite

31 ResumoCom o intuito de diagnosticar os principais agentes etiológi-cos das doenças atópicas em crianças brasileiras (3 a 16 anos), realizamos o presente estudo multicêntrico em oito diferentes regiões do Brasil (n=306), testando-se por meio do prick test, uma bateria padronizada de antígenos inalantes e alimentos (IFIDESA ARISTEGUI). Foram considerados positivos os diâmetros mé-dios de pápulas 3 mm. 22,2% dos pacientes tiveram teste negativo e a maioria restante foi positiva aos inalantes: D. pteronyssinus(Dpt) (66,6%) e D. farinae (Df) (66,0%), extrato de pó domiciliar (29,0%), epitélio de cão (19,2%), epitélio de gato (8,8%), penas (5,5%), fungos (4,2%), Penicillium sp (2,2%) e Lollium perene (0,6%). Com relação aos alimentos, observamos ocorrência de 9,1% de testes positivos, sendo a distribuição em ordem decrescente: leite de vaca (5,2%), amendoim (3,5%), milho (3,2), cacau e soja (2,2%), ovos e trigo (1,9%). Esses dados demonstram que os ácaros domésticos constituem-se nos principais agentes etiológicos da doença atópica em nosso meio, sendo necessária a determinação da população acarina em cada região do país e a aplicação de testes cutâneos com extratos específicos para cada realidade.J. pediatr. (Rio J.). 1995; 71(1):31-35: alergia, atopia, testes cutâneos, alérgenos inalantes, alimentos. AbstractIn order to determine the etiologic agents involved in atopic diseases in Brazilian children, we have performed this multicentric study in 8 areas in Brazil. We have done prick tests with inhalants and food antigens and analyzed skin tests results, considering positive the wheal mean diameter 3 mm. 22,2% of skin tests were negative and the majority were positive to inhalants: D.pteronyssinus(Dpt) (66,6%) and D. farinae(Df) (66,0%), house dust extract (29,0%), dog's epithelium (19,2%), cat's epithelium (8,8%), feather (5,5%), molds (4,2%), Penicillium sp (2,2%) and Lollium perene (0,6%). We have had 9,1% of food positive tests: cow milk (5,2%), peanut (3,5%), corn (3,2%), cocoa and soya (2,2%), eggs and wheat (1,9%). We have concluded that the domestic mites are the most important agents involved in the etiology of atopic diseases in Brazilian children, and the extracts involved, in line with the sensitization of each geographical area.J. pediatr. (Rio J.). 1995; 71(1):31-35: allergy, atopy, skin tests, inhalant allergens; food.Estima-se que o risco de alergia na população geral, seja próximo de 20%, aumentando para 50% se um dos pais for alérgico, ou para 66% se ambos o forem. 3,4,5 A importância relativa de um alérgeno individual é usualmente definida pela porcentagem de pacientes alérgi-cos que apresentem níveis séricos de IgEs específicas a esta proteína: quando mais de 60% dos pacientes apresentam IgE específica para determinado alérgeno, ele é considerado um alérgeno principal. 6 Cada indivíduo atópico apresenta um "marcador" alérgi-co, manifestado por hiperreatividade somente a certos antí-genos e determinado primariamente por fatores genéticos e exposição ambiental. 7,8 A resposta não se limita à sí...

show abstract

unclassified

Atopic diseases in Brazilian children - Etiologic multicentric study

Rizzo¹,

Solé²,

Rizzo³

et al. 1995

J Pediatr (Rio J)

View full text Add to dashboard Cite

show abstract

“…Moran & Wheeler have drawn attention to the importance of separating the effect of glutaraldehyde modification from the cross-linking which is also seen after glutaraldehyde treatment (64). Attempts to separate effects of glutaraldehyde-polymerization and mere aggregation have not been successful (65), From the data presented it seems that the highest reduction in allergenicity combined with retained immunogenicity has been achieved with material with a higher molecular weight than native allergen molecules, most of which are believed to be below 60 kD (56). Several explanations can be offered for the reduced allergenicity of these preparations.…”

Section: Effects Of Modification Polymerization or Epitopementioning

confidence: 99%

“…It is clearly different from the IgE response in man, in whom sensitization is believed to occur through the airways. Marsh has estimated the amount of AgE inhaled per year to be in the order of 1 |ig, and the amount actually extracted and absorbed could easily be 10-100 times smaller (56). Another point is the dose utilized in the animal experiments which is in the order of 100-500 ng of antigen per injection.…”

Section: Covalent Linking Of Allergen To Non-immunogenic Materialsmentioning

confidence: 99%

Improvement of specific immunotherapy by human IgG and modified allergens

Poulsen

Søundergaard

Weeke

1989

Allergy

View full text Add to dashboard Cite

“…Allergoids are allergens which have been chemically modified, for example with gluteraldehyde (Patterson et al, 1973), formaldehyde (Marsh, 1975) or urea (Ishizaka et al, 1974) so that they have a reduced ability to trigger mast cells through IgE but can still have immunological effects. It is possible to suppress IgE responses in mice with urea-denatured allergen (Takatsu & Ishizaka, 1975) and this effect can be transferred with splenic T cells (Takatsu & Ishizaka, 1976).…”

Section: The Use Of Denatured Allergens (Allergoids) In Animal Modelsmentioning

confidence: 99%