2002
DOI: 10.1042/bst0300925
|View full text |Cite
|
Sign up to set email alerts
|

Allergens of the cupin superfamily

Abstract: T h e cupin family comprises a family of proteins possessing a common P-barrel structure that is thought to have originated in a prokaryotic ancestor. This structural motif is found as a single domain in fungal spherulins, fern sporulins and the germins/oxalate oxidase proteins of plants, while the globular storage proteins of plants, called legumins (11 S) and euvicilins (7 S), are twodomain cupins. The 11 S globulins are hexameric heteroligomeric proteins of M , -360000, with each subunit comprising an acidi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
110
0
5

Year Published

2004
2004
2012
2012

Publication Types

Select...
4
2

Relationship

0
6

Authors

Journals

citations
Cited by 126 publications
(117 citation statements)
references
References 0 publications
2
110
0
5
Order By: Relevance
“…Our data suggest that the C-terminal polypeptide has been an overlooked contributor to soybean sensitivities. This hypothesis is supported by sequence alignments of Gly m Bd 28 K with members of the cupin family, which contain several known plant allergens (Mills et al 2002). We have also generated a homology model of Gly m Bd 28 K and found that the novel, dominant, IgE-binding epitope identified in this work may reside on the edge of a loop region that connects the two cupin domains.…”
Section: Introductionsupporting
confidence: 66%
See 4 more Smart Citations
“…Our data suggest that the C-terminal polypeptide has been an overlooked contributor to soybean sensitivities. This hypothesis is supported by sequence alignments of Gly m Bd 28 K with members of the cupin family, which contain several known plant allergens (Mills et al 2002). We have also generated a homology model of Gly m Bd 28 K and found that the novel, dominant, IgE-binding epitope identified in this work may reside on the edge of a loop region that connects the two cupin domains.…”
Section: Introductionsupporting
confidence: 66%
“…Sequence analysis indicated that Gly m Bd 28 K belongs to the cupin superfamily and contains two cupin domains, as has been documented for several legume protein allergens (Mills et al 2002). The cupin domains span residues F18-S148 near the N-terminal end and Y257-R407 near the C-terminal portion of the fulllength protein.…”
Section: Sequence Analysis and Model Construction Of Gly M Bd 28 Kmentioning
confidence: 60%
See 3 more Smart Citations