Allergic airway inflammation induces migration of mast cell populations into the mouse airway

Schmit, David; Le, Duc Dung; Heck, Sebastian; Bischoff, Markus; Tschernig, Thomas; Herr, Christian; Beißwenger, Christoph; Kobelt, Peter; Lepper, Phillipp Moritz; Chung, Kian Fan; Bals, Robert; Dinh, Q. Thai

doi:10.1007/s00441-017-2597-9

Cited by 13 publications

(9 citation statements)

References 51 publications

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“…Studies have also revealed an increase in the MC TC subtype in the airway submucosa and epithelium of severe, but not mild, asthmatic subjects [34]. In addition, it is notable that the majority of the MCs infiltrating the SMC layer in asthma are of the MC TC subtype [15] and an increased ratio of MC TC over MC T is also supported by studies in animal models of asthma [36,37].…”

Section: Protease Phenotype In Asthmamentioning

confidence: 85%

The emerging role of mast cell proteases in asthma

Pejler

2019

Eur Respir J

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It is now well established that mast cells (MCs) play a crucial role in asthma. This is supported by multiple lines of evidence, including both clinical studies and studies on MC-deficient mice. However, there is still only limited knowledge of the exact effector mechanism(s) by which MCs influence asthma pathology. MCs contain large amounts of secretory granules, which are filled with a variety of bioactive compounds including histamine, cytokines, lysosomal hydrolases, serglycin proteoglycans and a number of MC-restricted proteases. When MCs are activated, e.g. in response to IgE receptor cross-linking, the contents of their granules are released to the exterior and can cause a massive inflammatory reaction. The MC-restricted proteases include tryptases, chymases and carboxypeptidase A3, and these are expressed and stored at remarkably high levels. There is now emerging evidence supporting a prominent role of these enzymes in the pathology of asthma. Interestingly, however, the role of the MC-restricted proteases is multifaceted, encompassing both protective and detrimental activities. Here, the current knowledge of how the MC-restricted proteases impact on asthma is reviewed.

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Section: Protease Phenotype In Asthmamentioning

confidence: 85%

The emerging role of mast cell proteases in asthma

Pejler

2019

Eur Respir J

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“…Migration of MCs to the airways has previously been shown in mouse models of allergic airway inflammation [ 44 ] and the increase in pulmonary MCs is preceded by a recruitment of MC progenitors from the blood into the lung [ 45 ]. For this recruitment to occur, MC progenitors need to express integrin α 4 β 1 and α 4 β 7 , which interact with VCAM-1 on the lung endothelium [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells

et al. 2018

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Viral infections predispose to the development of childhood asthma, a disease associated with increased lung mast cells (MCs). This study investigated whether viral lower respiratory tract infections (LRTIs) can already evoke a MC response during childhood.Lung tissue from young children who died following LRTIs were processed for immunohistochemical identification of MCs. Children who died from nonrespiratory causes served as controls. MCs were examined in relation to sensitisation in infant mice exposed to allergen during influenza A infection.Increased numbers of MCs were observed in the alveolar parenchyma of children infected with LRTIs (median (range) 12.5 (0–78) MCs per mm2) compared to controls (0.63 (0–4) MCs per mm2, p=0.0005). The alveolar MC expansion was associated with a higher proportion of CD34+ tryptase+ progenitors (controls: 0% (0–1%); LRTIs: 0.9% (0–3%) CD34+ MCs (p=0.01)) and an increased expression of the vascular cell adhesion molecule (VCAM)-1 (controls: 0.2 (0.07–0.3); LRTIs: 0.3 (0.02–2) VCAM-1 per mm2 (p=0.04)). Similarly, infant mice infected with H1N1 alone or together with house dust mite (HDM) developed an increase in alveolar MCs (saline: 0.4 (0.3–0.5); HDM: 0.6 (0.4–0.9); H1N1: 1.4 (0.4–2.0); HDM+H1N1: 2.2 (1.2–4.4) MCs per mm2 (p<0.0001)). Alveolar MCs continued to increase and remained significantly higher into adulthood when exposed to H1N1+HDM (day 36: 2.2 (1.2–4.4); day 57: 4.6 (1.6–15) MCs per mm2 (p=0.01)) but not when infected with H1N1 alone.Our data demonstrate that distal viral infections in young children evoke a rapid accumulation of alveolar MCs. Apart from revealing a novel immune response to distal infections, our data may have important implications for the link between viral infections during early childhood and subsequent asthma development.

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“…Another study [ 11 ] demonstrated ventilation with 2% H 2 in the air significantly reduced the mRNA levels of the early growth responsive gene-1 (Egr-1) and chemokine (C-C motif) ligand 2 (CCL2), suggesting that H 2 can affect the progress of inflammation by regulating the transcription of proinflammatory regulatory factors and chemokines. In many diseases, such as airway inflammation and cerebral ischemia, type I hypersensitivity caused by mast cell activation will aggravate the tissue congestion and edema [ 12 , 13 ]. H 2 inhibits the body's inflammatory response by inhibiting Th2 reaction to reduce mast cell activation as well [ 14 ].…”

Section: Mechanisms Of the Action Of Hmentioning

confidence: 99%

Hydrogen: A Novel Option in Human Disease Treatment

Yang

Dong

et al. 2020

Oxidative Medicine and Cellular Longevity

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H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs and extrapulmonary organs from pathological stimuli in NCP patients. The potential mechanisms underlying the action of H2 gas are not clear. H2 gas may regulate the anti-inflammatory and antioxidant activity, mitochondrial energy metabolism, endoplasmic reticulum stress, the immune system, and cell death (apoptosis, autophagy, pyroptosis, ferroptosis, and circadian clock, among others) and has therapeutic potential for many systemic diseases. This paper reviews the basic research and the latest clinical applications of H2 gas in multiorgan system diseases to establish strategies for the clinical treatment for various diseases.

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Allergic airway inflammation induces migration of mast cell populations into the mouse airway

Cited by 13 publications

References 51 publications

The emerging role of mast cell proteases in asthma

The emerging role of mast cell proteases in asthma

Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells

Hydrogen: A Novel Option in Human Disease Treatment

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