Allergic aspergillosis of the respiratory tract

Shah, Ashok; Panjabi, Chandramani

doi:10.1183/09059180.00007413

Cited by 90 publications

(78 citation statements)

References 200 publications

(272 reference statements)

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“…A specific fungal complication in asthma or cystic fibrosis patients is the allergic bronchopulmonary aspergillosis (ABPA). In these patients, a repeated inhalation of Aspergillus spores leads to airway colonization that elicits an allergic response that is accompanied with elevated total IgE and anti‐ A. fumigatus IgE levels . Worldwide four million patients are suffering from this disease, which can lead to severe damage of the airways by bronchiectasis .…”

Section: Diseases Caused By a Fumigatus And Other Aspergillus Speciesmentioning

confidence: 99%

Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies

Kniemeyer

Ebel²,

Krüger

et al. 2016

Proteomics Clinical Apps

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Filamentous fungi of the genus Aspergillus play significant roles as pathogens causing superficial and invasive infections as well as allergic reactions in humans. Particularly invasive mycoses caused by Aspergillus species are characterized by high mortality rates due to difficult diagnosis and insufficient antifungal therapy. The application of immunoproteomic approaches has a great potential to identify new targets for the diagnosis, therapy, and vaccine development of diseases caused by Aspergillus species. Serological proteome analyses (SERPA) that combine 2D electrophoresis with Western blotting are still one of the most popular techniques for the identification of antigenic proteins. However, recently a growing number of approaches have been developed to identify proteins, which either provoke an antibody response or which represent targets of T-cell immunity in patients with allergy or fungal infections. Here, we review advances in the studies of immune responses against pathogenic Aspergilli as well as the current status of diagnosis and immunotherapy of Aspergillus infections.

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Section: Diseases Caused By a Fumigatus And Other Aspergillus Speciesmentioning

confidence: 99%

Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies

Kniemeyer

Ebel²,

Krüger

et al. 2016

Proteomics Clinical Apps

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“…This type of allergic reaction is usually associated with immune complexes consisting of fungal antigens and antibodies. Such complexes are formed by the presence of small amounts of fungus in the body (in the case of APBA) or repeated exposure to small conidia such these formed by Aspergillus fumigatus ( Figure 1) which achieved only 2-3.5 microns [25,26]. Such structures easily invade to the lower respiratory tract [25].…”

Section: Fungi and Allergic Reactionsmentioning

confidence: 99%

Fungi present in home and their impact on human health-A short review

Dyląg¹

2017

Insights Biol Med

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It is estimated that even up to 30% of buildings worldwide may be the subject of complaints connected with the quality of indoor air. Potential sources of air pollution can be both organic and inorganic particles. This article focuses on biological air pollutants from living and dead biological sources, especially those connected with fungi. Fungi found in the indoor air of domestic dwellings in a large extent are similar in their species composition to those found on the outside of the building. Microorganisms enters into the buildings during the airing of rooms or through the different slots and can develop on the surfaces of various materials. Intensively develops in a poorly ventilated, damp and dusty environments. For this reason the exposure to the indoor air pollution might be stranger for inhabitants than the expose to the impurities of the outdoor air. Presence of fungi in domestic dwellings can be very danger because of most often is associated with allergic reactions, mycotoxins, volatile organic compounds or even with fungal infections.

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“…126,127 A single patient may evolve over time from one Aspergillus-associated disease to another, or simultaneously may exhibit several such diseases. [127][128][129][130] This can create considerable confusion. For example, patients may exhibit serologic signs and clinical symptoms of ABPA but not have developed bronchiectasis on HRCT; this condition is termed allergic bronchopulmonary aspergillosis-serologic (ABPA-S).…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

Fungi in Cystic Fibrosis and Non–Cystic Fibrosis Bronchiectasis

Moss

2015

Semin Respir Crit Care Med

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Bronchiectasis is a pathologic bronchial dilatation with loss of function that can result from multiple inflammatory and infectious injuries to the conducting airways of the lung. Molds, particularly the filamentous fungus Aspergillus fumigatus, have been implicated as a common cause of both cystic fibrosis (CF) and non-CF bronchiectasis, the latter primarily in patients with severe asthma. The pathogenesis of mold-associated bronchiectasis is usually due to atopic sensitization to mold allergens in the presence of active chronic endobronchial fungal infection with host innate and adaptive immune deviation to a Th2-dominated inflammation, a condition known as allergic bronchopulmonary aspergillosis (ABPA) (or allergic bronchopulmonary mycosis if a non-Aspergillus mold is implicated). Diagnostic criteria of ABPA continue to evolve, while treatment relies upon downregulation of the allergic inflammatory response with immunomodulatory agents and antifungal pharmacotherapy.

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Allergic aspergillosis of the respiratory tract

Cited by 90 publications

References 200 publications

Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies

Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies

Fungi present in home and their impact on human health-A short review

Fungi in Cystic Fibrosis and Non–Cystic Fibrosis Bronchiectasis

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