Allergic Conjunctivitis and the Associated Risk of Migraine Among Children: A Nationwide Population-based Cohort Study

Wang, I-Chung; Tsai, Jeng-Dau; Shen, Te Chun; Lin, Cheng‐Li; Li, Tsai‐Chung; Wei, Chang-Ching

doi:10.1080/09273948.2016.1178303

Cited by 5 publications

(6 citation statements)

References 34 publications

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“…This study has several limitations. Although we adjusted for several potential confounders in the statistical analysis, several possible confounding variables associated with migraine, including family history of migraine, dietary habits, physical activity, occupational exposures, family member's smoking habits, stress, and emotional factors, were not included in our database 34 35. Besides, detailed information and laboratory data related to allergy, including serum IgE levels, eosinophil levels, skin prick tests, and family histories of atopy, were also unavailable in the database.…”

Section: Discussionmentioning

confidence: 99%

Children with Allergic Diseases Have An Increased Subsequent Risk of Migraine upon Reaching School Age

Wei

Lin

Shen

et al. 2018

Journal of Investigative Medicine

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The association between migraine and allergy has remained a subject of debate for more than a century. To systemically investigate the interaction between children with antecedent allergic diseases and their future risks of migraine on reaching school age, we recruited 16,130 children aged 7-18 with migraine diagnosed between 2000 and 2008, and 64,520 matched controls without a history of migraine. The ORs of migraine were calculated for the association with allergic diseases diagnosed before migraine diagnosis. The allergic diseases included atopic dermatitis, allergic conjunctivitis, allergic rhinitis (AR), and asthma. Children with preceding allergic diseases had a greater subsequent risk of migraine than the controls. Among the four evaluated diseases, AR had the highest adjusted OR (aOR) of 2.17 (95% CI 2.09 to 2.26). Children with all four allergic diseases had the highest aOR of 3.59 (95% CI 2.91 to 4.44). Further, an increasing trend of aORs was observed with more allergic disease-associated medical consulting. Our study indicates that children with allergic diseases are at increased subsequent risk of migraine when they reach school age, and the risk shows a cumulative effect of more allergic diseases and more allergy-related healthcare.

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Section: Discussionmentioning

confidence: 99%

Children with Allergic Diseases Have An Increased Subsequent Risk of Migraine upon Reaching School Age

Wei

Lin

Shen

et al. 2018

Journal of Investigative Medicine

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“… 11 12 26 Recently, population-based studies have been performed to overcome these limitations whereas most of them have still targeted children and adolescents or have examined the correlation between migraine and atopic disorders other than AD. 15 27 Previous studies have evaluated the risk of migraine in children with atopic disorders, and the increased risk of migraines has been explained by several stimuli in the brain development process caused by allergic diseases. 27 However, in this study, we analyzed the risk of migraine in patients older than 20 years to determine the effect of atopic disorders on the risk of migraine in adults.…”

Section: Discussionmentioning

confidence: 99%

“… 18 Previous epidemiological studies in children suggested that atopic disorders at a pediatric age can affect brain development and increase the risk of migraine. 15 27 A population-based study in Taiwan found higher association of migraine and AR (adjusted odds ratio [aOR], 2.17; 95% CI, 2.09–2.26), asthma (aOR, 1.76; 95% CI, 1.66–1.87), and AD (aOR, 1.74; 95% CI, 1.58–1.93) compared to controls in children aged 7 to 18 years. 27 According to a previous study, boys showed greater risk of migraine than girls.…”

Section: Discussionmentioning

confidence: 99%

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Atopic Disorders and Their Risks of Migraine: A Nationwide Population-Based Cohort Study

Han

Lee

Yook

et al. 2023

Allergy Asthma Immunol Res

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Purpose Migraine is a relatively common neurologic disorder. A possible link between atopic disorders and migraine has been suggested. This study investigated atopic disorders and their risks of migraine in the Korean population. Methods From the Korean National Health Insurance Service database, patients aged ≥ 20 years who underwent health screening between January and December of 2009 were enrolled. To evaluate the risk of migraine, Cox proportional hazards regression analyses were performed. Results In multivariable analysis, the atopic dermatitis group (adjusted hazard ratio [aHR], 1.28; 95% confidence interval [CI], 1.23–1.33), asthma group (aHR, 1.32; 95% CI, 1.30–1.34) and allergic rhinitis group (aHR, 1.45; 95% CI, 1.44–1.46) had significantly increased risks of migraine compared to their respective control groups ( P < 0.001). The patients with 1 (aHR, 1.43; 95% CI, 1.42–1.44), 2 (aHR, 1.50; 95% CI, 1.47–1.53), and 3 (aHR, 1.64; 95% CI, 1.43–1.88) atopic disorders had significantly increased risks of migraine compared to the control group ( P < 0.001). Conclusions Our results demonstrate that patients with atopic disorders may have increased risk of migraine and that the larger the number of concomitant atopic disorders, the higher the risk of migraine.

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“…15 It has been associated with several immunemediated conditions including asthma, allergic rhinitis, allergic conjunctivitis, atopic disease, coeliac disease, inflammatory bowel diseases, systemic lupus erythematosus and Sjögren's syndrome. [16][17][18][19] The possible role of mode of delivery has not been examined in prior studies of migraine. We hypothesised that caesarean section increases the risk of migraine and our aim was to explore the association between being delivered by caesarean section and migraine later in life.…”

Section: Introductionmentioning

confidence: 99%

Caesarean section and the association with migraine: a retrospective register-linked HUNT population cohort study

et al. 2020

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ObjectivesTo evaluate the association between caesarean section and migraine in a population-based register-linked cohort study.SettingData from the population-based Nord-Trøndelag Health Studies (HUNT2 and HUNT3) were linked to information from the Norwegian Medical Birth Registry.Participants65 343 participants responded to the headache questions in any of the two HUNT studies. Only those answering the headache questions in HUNT2 or 3 and had information about mode of delivery in the Norwegian Medical Birth Registry (born after 1967) were included. Our final sample consisted of 6592 women and 4602 men, aged 19–41 years.OutcomesORs for migraine given caesarean section. Analyses were performed in multivariate logistic regression models.ResultsAfter adjusting for sex, age and fetal growth restriction, delivery by caesarean section was not associated with migraine later in life (OR 0.86, 95% CI 0.64 to 1.15). Delivery by caesarean section was associated with a reduced OR of non-migrainous headache (OR 0.77, 95% CI 0.60 to 0.99).ConclusionNo association was found between caesarean section and migraine in this population-based register-linked study.

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Allergic Conjunctivitis and the Associated Risk of Migraine Among Children: A Nationwide Population-based Cohort Study

Abstract: Children with AC had a higher incidence and subsequent risk of migraine.

Cited by 5 publications

References 34 publications

Children with Allergic Diseases Have An Increased Subsequent Risk of Migraine upon Reaching School Age

Children with Allergic Diseases Have An Increased Subsequent Risk of Migraine upon Reaching School Age

Atopic Disorders and Their Risks of Migraine: A Nationwide Population-Based Cohort Study

Caesarean section and the association with migraine: a retrospective register-linked HUNT population cohort study

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