Allergic Contact Dermatitis

Mark, Barry J.; Slavin, Raymond G.

doi:10.1016/j.mcna.2005.08.008

Cited by 48 publications

(34 citation statements)

References 17 publications

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“…Consequently, the Ni-patch-induced oral mucosa lesions are probably related to bowel damage that occurs after ingestion of Ni-containing foods that in turn, causes the A Ni patch may also cause development of general reactions such as itching and dermographia, suggesting that the omPT can effectively identify Ni-sensitive patients. Furthermore, besides reinforcing the observations that Ni intake causes contact stomatitis [2,3] and may trigger a preexistent ACD [4][5][6], our results show that the omPT is more sensitive than the epicutaneous version in recognizing the adverse effects of ingesting Ni- containing foods in a population of symptomatic patients. In this regard, the significant portion of Ni-sensitive patients identified by the omPT, as well as the substantial clinical differences between positive and negative omPT patients further support this simple test as an effective diagnostic tool.…”

Section: Discussionsupporting

confidence: 87%

“…The main clinical manifestation caused by skin contact with Ni is allergic contact dermatitis (ACD), for which the epicutaneous patch test (ePT) is considered the gold standard for its diagnosis [2]. Similarly, Ni exposure through the intestinal mucosa following the ingestion of Ni-containing foods can result in other clinical conditions, including contact stomatitis [2,3].…”

mentioning

confidence: 99%

“…Similarly, Ni exposure through the intestinal mucosa following the ingestion of Ni-containing foods can result in other clinical conditions, including contact stomatitis [2,3]. Several studies have also reported that even small amounts of Ni ingested with a normal diet are enough to flare up a preexistent ACD [4][5][6].…”

mentioning

confidence: 99%

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Oral Mucosa Patch Test: A New Tool to Recognize and Study the Adverse Effects of Dietary Nickel Exposure

Picarelli

Tola

Vallecoccia

et al. 2010

Biol Trace Elem Res

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On contact with the skin, nickel may cause allergic contact dermatitis, which can be diagnosed by an epicutaneous patch test. Nickel exposure via the intestinal mucosa can induce diarrhea, abdominal pain, and swelling. The aim of the present study was to investigate the relationship between these symptoms and nickel intake by means of a novel oral mucosa patch test. Eighty-six patients with intestinal symptoms related to ingestion of nickel-containing foods were submitted to epicutaneous and oral mucosa patch tests for nickel. All patients with positive oral mucosa patch test results were subject to a low-nickel diet and monitored over time. Skin lesions were observed in 33 out of 86 (38.4%) patients evaluated by the epicutaneous patch test. Mucosal lesions were seen in 53 out of 86 (61.6%) patients given the oral mucosa patch test. After 2 months of a low-nickel diet, 52 out of 53 (98.1%) patients showed an improvement of their symptoms. There is a significant correlation between response time of the oral mucosa patch test and the latency of symptoms after ingestion of nickel-containing foods. Consequently, the oral mucosa patch test can be used to recognize and study the adverse effects of dietary nickel exposure that could be defined as allergic contact mucositis. A low-nickel diet is also shown to be an effective treatment for this condition.

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Section: Discussionsupporting

confidence: 87%

mentioning

confidence: 99%

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Oral Mucosa Patch Test: A New Tool to Recognize and Study the Adverse Effects of Dietary Nickel Exposure

Picarelli

Tola

Vallecoccia

et al. 2010

Biol Trace Elem Res

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“…The face, ear lobes, neck, and wrists are the most commonly involved sites. The diagnosis is made by means of the ePT, able to provoke delayed lesions, as a type IV hypersensitivity reaction [3].…”

Section: Introductionmentioning

confidence: 99%

Nickel-Related Intestinal Mucositis in IBS-Like Patients: Laser Doppler Perfusion Imaging and Oral Mucosa Patch Test in Use

Borghini

Puzzono

Rosato

et al. 2016

Biol Trace Elem Res

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Nickel (Ni) is often the trigger of irritable bowel syndrome (IBS)-like gastrointestinal disorders: its ingestion may cause allergic contact mucositis, identifiable by means of oral mucosa patch test (omPT). OmPT effectiveness has been proven, but it is still an operator-dependent method. Laser Doppler perfusion imaging (LDPI) was tested to support omPT in Ni allergic contact mucositis diagnosis. Group A: 22 patients with intestinal/systemic symptoms related to the ingestion of Ni-containing foods. Group B: 12 asymptomatic volunteers. Ni-related symptoms and their severity were tested by a questionnaire. All patients underwent Ni omPT with clinical evaluation at baseline (T0), after 30 min (T1), after 2 h (T2), and after 24-48 h (T3). LDPI was performed to evaluate the mean mucosal perfusion at T0, T1, and T2. Statistical analysis was performed by ANOVA test and Bonferroni multiple-comparison test. All 22 Ni-sensitive patients (group A) presented oral mucosa hyperemia and/or edema at T2. Eight out of the same 22 patients presented a local delayed vesicular reaction at T3 (group A1), unlike the remaining 14 out of 22 patients (group A2). All 12 patients belonging to control group B did not show any alteration. The mean mucosal perfusion calculated with LDPI showed an increase in both subgroups A1 and A2. In group B, no significant perfusion variations were observed. LDPI may support omPT for diagnostic purposes in Ni allergic contact mucositis. This also applies to symptomatic Ni-sensitive patients without aphthous stomatitis after 24-48 h from omPT and that could risk to miss the diagnosis.

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“…To explain the immunologic mechanism of ID reactions, a chain reactions induced by the release of fungal antigens from the site of infection have been proposed:5 opsonisation by host antibodies and spread of sensitised T-helper 1 cells and their cytokines to other parts of the body. Classically, ID reactions are known to be caused by type 4 delayed hypersensitivity to a distant focus of any type of infection 6…”

Section: Discussionmentioning

confidence: 99%

Autosensitisation (Autoeczematisation) reactions in a case of diaper dermatitis candidiasis

Chirac

Brzeziński

Chiriac³

et al. 2014

Niger Med J

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Diaper dermatitis is the most common cutaneous diagnosis in infants. Most cases are associated with the yeast colonisation of Candida or diaper dermatitis candidiasis (DDC). It is an irritating and inflammatory acute dermatitis in the perineal and perianal areas resulting from the occlusion and irritation caused by diapers. Autoeczematization to a distant focus of dermatophyte infection very rarely presents as DDC. We present a 1-month-old boy with lesion on diaper area (gluteal area, perineum, groin and genitalia) and with clusters of pustules and vesicles on a large erythematous base over the dorsal area of both hands.

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Allergic Contact Dermatitis

Cited by 48 publications

References 17 publications

Oral Mucosa Patch Test: A New Tool to Recognize and Study the Adverse Effects of Dietary Nickel Exposure

Oral Mucosa Patch Test: A New Tool to Recognize and Study the Adverse Effects of Dietary Nickel Exposure

Nickel-Related Intestinal Mucositis in IBS-Like Patients: Laser Doppler Perfusion Imaging and Oral Mucosa Patch Test in Use

Autosensitisation (Autoeczematisation) reactions in a case of diaper dermatitis candidiasis

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