Allergic contact dermatitis by isobornyl acrylate in glucose monitoring devices: Report of two cases

Jáuregui, I; Sánchez, J.; Segurola, Aritza; Galán, Cristina; Seras, Yolanda; Setién, Pedro Gamboa

doi:10.1111/cod.13349

Cited by 6 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, essential aspects such as obligations of manufacturers to co-operate in the work-up of adverse reactions to medical devices and full product ingredient/content information are not implemented. Therefore, it was only thanks to the combined investigative efforts of dermatologists and chemists that ACD to glucose sensors, insulin pumps, and similar equipment could be related to certain allergens, namely isobornyl acrylate [229][230][231][232][233][234][235] and N,N'-dimethylacrylamide [236]. These adhesive monomers apparently leached from the plastic encasing onto the outer surface of the adhesive (which originally did not contain these chemicals) and sensitised patients, owing to the prolonged exposure to the devices of several days to few weeks at a time.…”

Section: Medical Devicesmentioning

confidence: 99%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

View full text Add to dashboard Cite

Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

show abstract