Allergic contact dermatitis caused by capryloyl glycine in an atopic dermatitis patient

Sodium stearoyl glutamate: Another amino acid alkyl amide sensitizer in cosmetics

“…Also in the current case, the skin reaction was so severe that systemic corticosteroids had been necessary to alleviate the patient's condition. Recently published cases of ACD from AAAAs concerned oleoyl tyrosine, 1,4 isopropyl lauroyl sarcosinate 5 and capryloyl glycine, the latter also potentially present in hydrating creams used by atopic dermatitis patients 6,7 . Because in our patient both episodes of ACD occurred quite rapidly, that is, within 1 day after using both creams, she had likely been previously sensitized to these substances, or to one of them, as their similar chemical structure might also allow cross‐reactivity (Figure 2).…”

“…Recently published cases of ACD from AAAAs concerned oleoyl tyrosine, 1,4 isopropyl lauroyl sarcosinate 5 and capryloyl glycine, the latter also potentially present in hydrating creams used by atopic dermatitis patients. 6,7 Because in our patient both episodes of ACD occurred quite rapidly, that is, within 1 day after using both creams, she had likely been previously sensitized to these substances, or to one of them, as their similar chemical structure might also allow cross-reactivity (Figure 2). Co-reactivity, from concomitant exposure, is an alternative explanation for the second episode, as both sodium stearoyl glutamate and capryloyl glycine were present in the same culprit product (i.e., after-sun).…”