Allergic contact dermatitis due to burdock (<i>Arctium lappa</i>)

Rodríguez, Pilar Guerra; Blanco, J.; Juste, S.; Garcés, M.; Pérez, Ruperto González; Alonso, L.; Marcos, M.

doi:10.1111/j.1600-0536.1995.tb00524.x

Cited by 30 publications

(25 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In further support, Sohn et al also showed that REB suppresses IL-4 secretion from mitogen stimulated splenocytes [20]. On contrary, Sasaki et al [21] and Rodriguez et al [22] showed in case report that consumption of root of burdock result in allergic reactions. These conflicting results may be attributed to: 1) differences between in vitro and in vivo studies, (2) differences between raw burdock and boiled burdock, (3) differences between compounds of bioactive secondary metabolites of burdock in different regions.…”

Section: Discussionmentioning

confidence: 87%

Comparison of the Immunomodulatory Properties of Root and Leaves of Arctium Lappa (Burdock) in Vitro

Ahmadabad

Behnamfar

Firizi

et al. 2017

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: The roots and leaves of Arctium lappa (burdock) have been used for different therapeutic purposes, especially for diseases linked to chronic inflammation. Objectives: The present study was designed to evaluate and compare the immunomodulatory activities of root extract of burdock and leaves extract of burdock in vitro. Methods: In this experimental study, PHA-or LPS-stimulated splenocytes were treated with different concentrations of root or leaves extract of burdock and proliferation of splenocytes measured by MTT assay. The levels of IFN-γ and IL4 in the supernatants of PHAstimulated splenocytes determined using ELISA. We also studied the effects of root and leaves extract of burdock on Nitric Oxide production by LPS-stimulated macrophages using the Griess reagent. The data were analyzed by one-way ANOVA followed by Tukey's post-test using GraphPad Prism software, version 5.0. Results: Our findings showed that both root and leaves extract of burdock have suppressive effects on LPS-stimulated splenocytes proliferation, IL-4 secretion from PHA-stimulated splenocytes, and NO production from LPS-stimulated macrophage and stimulatory effects on PHA-stimulated splenocytes proliferation, and IFN-γ secretion from PHA-stimulated splenocytes. Although both root and leaves extract of burdock had similar immunomodulatory effects in vitro, stronger immunomodulatory effects seen in root extract of burdock. Conclusions: According to our results, we suggest that root of burdock is better option than leaves of burdock in modulation immune responses and inflammations.

show abstract

Section: Discussionmentioning

confidence: 87%

Comparison of the Immunomodulatory Properties of Root and Leaves of Arctium Lappa (Burdock) in Vitro

Ahmadabad

Behnamfar

Firizi

et al. 2017

Zahedan J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…Its carrot‐like root is commonly cooked and eaten in Japan. As far as we know, only one other case of allergy to burdock has been reported 4 . This involved contact dermatitis to burdock, and no immediate‐type allergy has been documented in the past.…”

Section: Discussionmentioning

confidence: 96%

Anaphylaxis due to burdock

et al. 2003

View full text Add to dashboard Cite

A 53‐year‐old Japanese man, with a history of developing urticaria (once after consuming mackerel and 10 times after consuming boiled burdock, carrot, curry, and rice), presented with redness over his entire body and dyspnea 1 h after eating boiled burdock. Physical examination revealed a low blood pressure of 64/29 mmHg and stridor, together with striking redness of the whole body; he was diagnosed to be in anaphylactic shock. He recovered from the anaphylactic shock with subcutaneous injection of epinephrine (1 mg) and an intravenous drip of lactate Ringer's solution containing hydrocortisone (100 mg) and dexamethasone (8 mg). Laboratory examination and skin prick test were performed 3 weeks after his first visit. The total immunoglobulin E (radioimmunosobent test) level was 190 IU/mL, and specific immunoglobulin E for mackerel and carrot was found to be negative. Skin prick test was performed on the volar forearm with burdock, carrot, and turmeric after he had not taken any medication for 1 week. It was also conducted in normal healthy persons at the same time. A skin prick was made with a PRICK‐LANCETTER® (made in Sweden) using 1% histamine chloride solution and 0.9% saline solution as positive (3+) and negative (–) controls, respectively. For skin prick tests, burdock and carrot were employed in their boiled and raw conditions. Turmeric powder was diluted to 1% and 10% in petrolatum. Skin prick tests were judged according to the recommendations of the European Academy of Allergy and Clinical Immunology (Shono M. The skin test learned in Finland. Hifubyou‐Shinryoh 1999; 25 (3): 255–269; Bernstein IL. Proceedings of the task force on guidelines for standardizing old and new technologies used for the diagnosis and treatment of allergic diseases. J Allergy Clin Immunol 1988; 82: 487–526). The results of the skin prick tests (Table 1) were positive for raw and boiled burdock and carrot, but negative for turmeric (Fig. 1). Two normal healthy controls showed negative responses to all substances. Results of skin prick test Wheal size (mm) Score Boiled burdock3 × 4(3+)Boiled carrot3 × 3(3+)Raw burdock3 × 4(3+)Raw carrot3 × 3(3+)1% turmeric diluted with petrolatum0 × 0(–)10% turmeric diluted with petrolatum0 × 0(–)1% histamine chloride4 × 4(3+)Normal saline–(–) 1 Skin prick tests performed on the flexor surface of the forearm (left: 1, boiled burdock; 2, boiled carrot; 3, raw burdock; 4, raw carrot; right: 5, 1% turmeric; 6, 10% turmeric; 7, histamine chloride; 8, normal saline) This is the first case report of anaphylaxis due to burdock.

show abstract

“…Antibacterial in food-borne pathogens Rodriguez et al (1995) Case reports-folk medicine Orthopedic plasters from root of Arctium lappa…”

Section: Lou Et Al (2010) Leaf Extract Analysis Bioactive Fraction Omentioning

confidence: 99%

The Effect of Burns & Wounds (B&W)/Burdock Leaf Therapy on Burn-Injured Amish Patients

Kolacz¹,

Jaroch²,

Bear³

et al. 2014

J Holist Nurs

View full text Add to dashboard Cite

show abstract

Allergic contact dermatitis due to burdock (Arctium lappa)

Cited by 30 publications

References 2 publications

Comparison of the Immunomodulatory Properties of Root and Leaves of Arctium Lappa (Burdock) in Vitro

Comparison of the Immunomodulatory Properties of Root and Leaves of Arctium Lappa (Burdock) in Vitro

Anaphylaxis due to burdock

The Effect of Burns & Wounds (B&W)/Burdock Leaf Therapy on Burn-Injured Amish Patients

Contact Info

Product

Resources

About