Allergic Contact Dermatitis from Diethyl Sebacate in a Topical Antimycotic Medicament

Hirao, Ayaka; Oiso, Naoki; Hama, Megumi; Higashimori, Noriko; Tatsumi, Yoichi; Kawada, Akira

doi:10.4236/jcdsa.2012.23040

Cited by 1 publication

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is widely used as a food flavoring agent and is also used in perfumes [71]. It is reported that diethyl sebacate can cause allergic contact dermatitis [72].…”

Section: Fragrance Categorymentioning

confidence: 99%

Suspect and non-target screening of chemicals in household cleaning products, and their toxicity assessment

Park

Yun

Yoon

et al. 2023

Environmental Engineering Research

View full text Add to dashboard Cite

In this study, 31 household spray-type cleaning products from 10 categories were examined to identify the substances contained in these products and evaluate their resulting toxicities. After substance detection via LC-QTOF-MS, suspect and non-target screenings were performed using UNIFI software. A total of 48 substances were identified during suspect screening. Among them, surfactant (freq. 22/31(71.0%)), plasticizer (freq. 23/31(74.2%)), antioxidant (freq. 20/31(64.5%)) were detected with high frequencies. Among the 48 compounds, tributyl citrate acetate was the most frequently detected (frequency 13/31, 41.9%). In addition, 51 substances were identified via non-target analysis. Among them, oleamide, a type of surfactant, showed a high frequency of detection (22/31(71.0%)). The toxicities of the 98 substances (suspect: 47 (except for confidence level 5) and non-target: 51) identified were evaluated using the European Chemicals Agency (ECHA) database and Toxtree. Among them, 20 substances were classified as a substance of caution. The risk assessment for 3 substances identified with references standards was also performed. The suspect and non-target screening technique proved to be a useful method that can be applied when there are many non-specific chemicals and their components in the consumer products are not well known.

show abstract

“…It is widely used as a food flavoring agent and is also used in perfumes [71]. It is reported that diethyl sebacate can cause allergic contact dermatitis [72].…”

Section: Fragrance Categorymentioning

confidence: 99%