Allergic contact dermatitis from resacetophenone (2′,4′‐dihydroxyacetophenone; CAS no. 89‐84‐9) in an antifungal nail preparation

Abstract

We report the first two cases of allergic contact dermatitis from resacetophenone in a nail antifungal preparation. Patch tests gave positive reactions to resacetophenone (0.1% and 1% pet.). No cross‐reactions with resorcinol or phenylethyl resorcinol were found. Patch testing with individual ingredients is paramount to diagnose new allergens.

Contact allergy to resacetophenone

“…The pure chemical is an irritant 12 . Contact allergy to it in the same antifungal product has recently been reported 1 …”

“…12 Contact allergy to it in the same antifungal product has recently been reported. 1 Acetophenone azine is an emerging contact allergen that often is associated with the use of sports equipment 13 and footwear 14 containing the foam elastomer ethyl vinyl acetate. The compound is probably not intentionally added to ethyl vinyl acetate but is likely the result of reactions between other additives that take place during the manufacturing process.…”

“…We report the first case of contact allergy to resacetophenone outside Spain 1 and review contact allergy to other acetophenone derivatives.…”

Allergic contact dermatitis from hydroxyacetophenone in an anti‐wrinkle facial serum with flare‐up reactions triggered by the repeated open application test

“…ACD to 2,4‐dihydroxyacetophenone (resacetophenone; CAS 89‐84‐9), a related compound present in antifungal nail preparations, 9 has been recently described, but cross‐reactivity between both compounds has not yet been explored. Resacetophenone could not be patch tested in our patient.…”