“…Hypersensitivity to strawberry fruit (Fragaria × ananassa), due to cross-reactivity with antibodies developed against birch (Betula verrucosa) pollen allergens, is commonly reported among the general population, but only a few studies have been reported. − The main clinical (in vivo) symptoms caused by birch pollen allergen Bet v 1-mediated cross-reactivity are associated with oral allergy syndromes, local reactions such as itching and dermatitis, and rarely systemic symptoms such as contact urticaria, asthma, and anaphylactic shock. , Fra a 1 proteins, homologues of the birch pollen allergen Bet v 1 have been isolated from strawberry fruit, but also genes homologous to profilins (Fra a 4) and lipid transfer proteins (LTP; Fra a 3) have been identified in a strawberry cDNA library, implying that proteins of other allergen families are also expressed in strawberry fruit. It is known that in northern Europe sensitization to Bet v 1 is dominant, and it has been reported that about 30% of patients in northern Europe, with self-reported hypersensitivity to food, also show adverse reactions to strawberry .…”