Allergic contact dermatitis from undecylenic acid in a commercial antifungal nail solution

Anguíta, Juan; Escutia, B.; Marí, J. I.; Rodríguez, M.; Cuadra, J. de la; Aliaga, Adolfo

doi:10.1034/j.1600-0536.2002.460210.x

Cited by 8 publications

(5 citation statements)

References 4 publications

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“…Undecylenic acid is used as a component of antifungal nail solutions, powders, and deodorants, and also in commercial nail lacquers and dental products in order to prevent Candida biofilm formation . Despite undecylenic acid being a widely used compound, ACD caused by it is apparently not frequent, and only two cases have been previously reported in the literature . This is the second reported case caused by a nail solution.…”

Section: Discussionmentioning

confidence: 98%

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Allergic contact dermatitis caused by undecylenic acid in an antifungal nail solution

et al. 2019

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Section: Discussionmentioning

confidence: 98%

“…The optimum patch test concentration of this compound has not been determined; 1%, 2%, 2.5% and 4% pet. have been used, according to the published data . In our opinion, a concentration of 1% pet.…”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis caused by undecylenic acid in an antifungal nail solution

et al. 2019

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“…Moreover, two anecdotal reports exist on contact allergies to undecylenic acid in humans (Gelbfarb and Leider 1960;Anguita et al 2002). So, this substance is most likely properly defined as a sensitizing substance.…”

Section: Undecylenic Acid Is Most Likely a Weak Sensitizer Based On Hmentioning

confidence: 99%

Unsaturated compounds induce up-regulation of CD86 on dendritic cells in the in vitro sensitization assay LCSA

et al. 2015

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Unsaturated compounds are known to cause false-positive reactions in the local lymph node assay (LLNA) but not in the guinea pig maximization test. We have tested a panel of substances (succinic acid, undecylenic acid, 1-octyn-3-ol, fumaric acid, maleic acid, linoleic acid, oleic acid, alpha-linolenic acid, squalene, and arachidonic acid) in the loose-fit coculture-based sensitization assay (LCSA) to evaluate whether unspecific activation of dendritic cells is a confounder for sensitization testing in vitro. Eight out of 10 tested substances caused significant up-regulation of CD86 on dendritic cells cocultured with keratinocytes and would have been classified as sensitizers; only succinic acid was tested negative, and squalene had to be excluded from data analysis due to poor solubility in cell culture medium. Based on human data, only undecylenic acid can be considered a true sensitizer. The true sensitizing potential of 1-octyn-3-ol is uncertain. Fumaric acid and its isomer maleic acid are not known as sensitizers, but their esters are contact allergens. A group of 18- to 20-carbon chain unsaturated fatty acids (linoleic acid, oleic acid, alpha-linolenic acid, and arachidonic acid) elicited the strongest reaction in vitro. This is possibly due to the formation of pro-inflammatory lipid mediators in the cell culture causing nonspecific activation of dendritic cells. In conclusion, both the LLNA and the LCSA seem to provide false-positive results for unsaturated fatty acids. The inclusion of T cells in dendritic cell-based in vitro sensitization assays may help to eliminate false-positive results due to nonspecific dendritic cell activation. This would lead to more accurate prediction of sensitizers, which is paramount for consumer health protection and occupational safety.

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“…UA, which is an active ingredient of Trosid, next to thioconazole and ethyl acetate, was again recognized as the allergen. [12] Following a GPMT (guinea pig maximization test) for UA in 2008, it should be classified and labeled as a skin sensitizer according to the European Dangerous Substance Directive (67/548/EEC). [13] UA forms an alternative treatment for allergic fungal sinusitis (AFS), a pathology often related to chronic rhinosinusitis (CRS).…”

Section: Antifungal Activitymentioning

confidence: 99%

“…The one-pot reaction of UA and alcohols with sol-gel entrapped lipase and sol-gel entrapped 12 ] leads to saturated esters. It was essential that both the enzyme and the metal catalyst were sol-gel entrapped.…”

Section: Trans(esterification) Productsmentioning

confidence: 99%

Undecylenic Acid: A Valuable and Physiologically Active Renewable Building Block from Castor Oil

2009

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A lot of attention is currently being paid to the transition to a biobased economy. In this movement, most efforts concentrate on the development of bioenergy applications including bioethanol, biodiesel, thermochemical conversion of biomass, and others. However, in the energy sector other nonbiomass alternatives are known, whereas no valuable alternatives are available when thinking about chemical building blocks. Therefore, it is also essential to develop new routes for the synthesis of bio-based chemicals and materials derived thereof. Such intermediates can originate either from plants or from animals. Castor oil is a non-edible oil extracted from the seeds of the castor bean plant Ricinus communis (Euphorbiaceae), which grows in tropical and subtropical areas. Globally, around one million tons of castor seeds are produced every year, the leading producing areas being India, PR China, and Brazil.2 10-Undecenoic acid or undecylenic acid is a fatty acid derived from castor oil that, owing to its bifunctional nature, has many possibilities to develop sustainable applications.

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Allergic contact dermatitis from undecylenic acid in a commercial antifungal nail solution

Cited by 8 publications

References 4 publications

Allergic contact dermatitis caused by undecylenic acid in an antifungal nail solution

Allergic contact dermatitis caused by undecylenic acid in an antifungal nail solution

Unsaturated compounds induce up-regulation of CD86 on dendritic cells in the in vitro sensitization assay LCSA

Undecylenic Acid: A Valuable and Physiologically Active Renewable Building Block from Castor Oil

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