Allergic contact dermatitis in a psoriasis patient caused by cetylstearyl alcohol

Navarro‐Triviño, Francisco José; Ruiz‐Villaverde, Ricardo

doi:10.1111/cod.14136

Cited by 4 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The non-noble metal nickel was the most frequently reported (17.6%), followed by a fragrance mix containing amyl cinnamal, cinnamal, hydroxycitronellal, cinnamyl alcohol, eugenol, geraniol, isoeugenol, and oakmoss absolute (7%); the biocide methylisothiazolinone (6.1%); the transition metal cobalt (5.3%); and the natural resin colophonium (4.2%). Among the top ten haptens, only paraphenylenediamine, a primary intermediate commonly used in oxidative hair dyes, had a lower frequency in the psoriasis group (2.7%) than in the nonpsoriasis one (3.6%) [ 38 ]. Likewise, García-Souto et al found the most frequent sensitizing hapten in a psoriasis group to be the metal hapten nickel sulfate (34.6%), followed by the biocide mix methylchloroisothiazolinone/methylisothiazolinone (6.2%), and the organomercurial preservative thimerosal, also known as thiomersal (5.4%), comparable to the frequency of contact allergens within an atopic dermatitis group [ 2 ].…”

Section: Skin Patch Testing For Contact Cell-mediated Hypersensitivit...mentioning

confidence: 99%

“…One study reported dithranol to be a contact trigger in 6.5% of patients. These haptens may be involved in cases refractory to treatment [ 2 , 26 , 31 , 34 , 38 ]. A recent case of allergic contact dermatitis in a psoriasis patient caused by the excipient cetylstearyl alcohol was recently reported by Navarro-Triviño et al [ 39 ].…”

Section: Skin Patch Testing For Contact Cell-mediated Hypersensitivit...mentioning

confidence: 99%

See 1 more Smart Citation

Allergic Contact Cell-Mediated Hypersensitivity in Psoriasis: A Narrative Minireview

et al. 2022

View full text Add to dashboard Cite

The dysfunctionality of the protective skin barrier in psoriasis allows easier cutaneous penetration of various contact haptens; thus, such patients can develop allergic contact hypersensitivity as a comorbidity. Both skin conditions involve T-cell-mediated mechanisms. Dermatologists and allergists should consider assessing allergic contact cell-mediated hypersensitivity in selected psoriasis patients, especially those with palmoplantar psoriasis and who are refractory to topical treatments, and in patients with psoriasis, with or without arthritis, treated with biologics that present skin lesions clinically suggestive of contact dermatitis.

show abstract

Section: Skin Patch Testing For Contact Cell-mediated Hypersensitivit...mentioning

confidence: 99%

Section: Skin Patch Testing For Contact Cell-mediated Hypersensitivit...mentioning

confidence: 99%

Allergic Contact Cell-Mediated Hypersensitivity in Psoriasis: A Narrative Minireview

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Some emulsifiers destroy the skin barrier and trigger allergies due to the permeation of antigens into the skin [ 17 , 18 ]. Recently, the increase in the number of patients with emulsifier contact dermatitis has become a problem [ 19 , 20 ]. Therefore, micropig skin tissues and start-M™ skin membranes were used to assess the permeability of SNPs in a diffusion system.…”

Section: Resultsmentioning

confidence: 99%

Safety Assessment of Starch Nanoparticles as an Emulsifier in Human Skin Cells, 3D Cultured Artificial Skin, and Human Skin

et al. 2023

View full text Add to dashboard Cite

Emulsion systems are widely used in various industries, including the cosmetic, pharmaceutical, and food industries, because they require emulsifiers to stabilize the inherently unstable contact between oil and water. Although emulsifiers are included in many products, excessive use of emulsifiers destroys skin barriers and causes contact dermatitis. Accordingly, the consumer demand for cosmetic products made from natural ingredients with biocompatibility and biodegradability has increased. Starch in the form of solid nanosized particles is considered an attractive emulsifier that forms and stabilizes Pickering emulsion. Chemical modification of nanosized starch via acid hydrolysis can effectively provide higher emulsion stability. However, typical acid hydrolysis limits the industrial application of starch due to its high time consumption and low recovery. In previous studies, the effects of starch nanoparticles (SNPs) prepared by treatment with acidic dry heat, which overcomes these limitations, on the formation and stability of Pickering emulsions were reported. In this study, we evaluated the safety of SNPs in skin cell lines, 3D cultured skin, and human skin. We found that the cytotoxicity of SNPs in both HaCaT cells and HDF cells could be controlled by neutralization. We also observed that SNPs did not induce structural abnormalities on 3D cultured skin and did not permeate across micropig skin tissue or human skin membranes. Furthermore, patches loaded with SNPs were found to belong in the “No irritation” category because they did not cause any irritation when placed on human skin. Overall, the study results suggest that SNPs can be used as a safe emulsifier in various industries, including in cosmetics.

show abstract

“…Topical drugs have already been described as sensitizing 3 ; in particular, ACD to chlorocresol contained in topical drugs have already been reported 3 and might be under‐estimated since its presence is up to 11.4% in the topical corticosteroid creams 4 . Although cetostearyl alcohol is widely present in cosmetic products and hand sanitizers as well, cases of ACD to this excipient are mostly related to its use in topical drugs, mainly used to treat a pre‐existing dermatitis, as an already damaged skin may enhance the possibility of developing contact sensitization 5,6 …”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis due to excipients in topical drugs

et al. 2022

View full text Add to dashboard Cite

condition was felt to be similar to cases reported from India due to allergy to Parthenium hysterophorus. 6 He was shown a picture of this weed and confirmed that it flourished in Islamabad's rural areas where his family lived. Parthenium, a well-known cause of airborne ACD in India, is a growing concern in Pakistan. 7 It does not grow in Europe, but a case of parthenium allergy in a traveller from Pakistan has been reported by British authors. 8 The pattern of SLs exposure (different plants in different countries) made the diagnosis particularly difficult in our case that was possibly due to co-reactivity rather than to sensitization to the same allergen/s. As a matter of fact, we do not know which components in artichoke/SL mix/parthenium may explain such co-reactivity and the final diagnosis mainly relied upon the history because we did not patch test parthenium extract nor single specific allergens.With time, SLs allergic patients may develop chronic actinic dermatitis (CAD) which is associated with photosensitivity. 9 In our patient histology was not suggestive of CAD. Minimal erythema dose testing was not performed but he did not overreact to the standard irradiation used for photo-patch testing.Compositae airborne ACD can become severe, widespread and difficult to treat. Dubilumab has been used in two cases 10 and also in CAD 11 but its possible effects on SLs allergy are controversial 10,12 and require careful monitoring. ACKNOWLEDGEMENTSThanks are due to Lucia Volpicelli for her expert technical assistance.

show abstract

Allergic contact dermatitis in a psoriasis patient caused by cetylstearyl alcohol

Cited by 4 publications

References 7 publications

Allergic Contact Cell-Mediated Hypersensitivity in Psoriasis: A Narrative Minireview

Allergic Contact Cell-Mediated Hypersensitivity in Psoriasis: A Narrative Minireview

Safety Assessment of Starch Nanoparticles as an Emulsifier in Human Skin Cells, 3D Cultured Artificial Skin, and Human Skin

Allergic contact dermatitis due to excipients in topical drugs

Contact Info

Product

Resources

About