Allergic contact dermatitis of the eyelids: An interdisciplinary review

Turkiewicz, Michal; Shah, Ami A.; Yang, Yul W.; Mangold, Aaron R.; Shen, Joanne F

doi:10.1016/j.jtos.2023.03.001

Cited by 6 publications

(4 citation statements)

References 47 publications

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“…Fragrances (fragrance mix I, fragrance mix II, and Myroxylon pereira) are highly involved in eyelid dermatitis both through direct application of cosmetics and through air fresheners (e.g., essential oil diffusers). [27][28][29] Among the fragrances, only positive reactions to fragrance mix II resulted significantly higher in E-Group than in NE-Group. Regarding the positive reactions to the other 2 allergens significantly more frequent in E-Group patients, both surfactants, DMAPA is responsible for eyelid dermatitis due to shampoos and make-up removers, 30,31 while SSO is a water-dispersible emulsifier present in several cosmetics 4 and ophthalmic products, 32 tested in the SIDAPA baseline series since 2016.…”

Section: Discussionmentioning

confidence: 87%

“…Surprisingly, MCI/MI resulted positive more frequently in NE‐Group than in E‐Group (6.5% and 5.5%, respectively), probably due to the widespread use of these preservatives in household products, such as paints and domestic detergents. Fragrances (fragrance mix I, fragrance mix II, and Myroxylon pereira ) are highly involved in eyelid dermatitis both through direct application of cosmetics and through air fresheners (e.g., essential oil diffusers) 27–29 . Among the fragrances, only positive reactions to fragrance mix II resulted significantly higher in E‐Group than in NE‐Group.…”

Section: Discussionmentioning

confidence: 99%

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Contact allergy to SIDAPA baseline series allergens in patients with eyelid dermatitis: An Italian multicentre study

Stingeni,

Foti,

Guarneri

et al. 2024

Contact Dermatitis

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BackgroundEyelid dermatitis is a frequent reason of dermatological consultation. Its aetiology is not univocal, being contact dermatitis, both allergic and irritant, the most frequent. The primary sources of allergen exposure include cosmetics, metals, and topical medications, from direct, indirect, or airborne contact.ObjectivesTo define the frequency of positive patch test reactions to SIDAPA baseline series allergens, to document positive allergens, and to precise the final diagnosis in patients with eyelid involvement.MethodsA total of 8557 consecutive patients from 12 Italian Dermatology Clinics underwent patch testing with SIDAPA baseline series in 2018 and 2019. Patients were divided into two groups: (i) with eyelid involvement with or without other involved sites (E‐Group) and (ii) without eyelid involvement (NE‐Group). The final diagnosis and the frequency of positive relevant patch test reactions were evaluated.ResultsE‐Group consisted of 688 patients (females 78.6%, mean age 45.3 years), 8.0% of 8557 consecutively patch‐tested patients. The final diagnosis in E‐Group was ADC in 42.4%, ICD in 34.2%, and AD in 30.5%. The highest reaction rates were elicited by nickel sulphate and methylchloroisothiazolinone/methylisothiazolinone in both E‐Group and NE‐Group, even if these allergens were significantly more frequently positive in NE‐Group patients than in E‐Group ones. Positive patch test reactions to fragrance Mix II, dimethylaminopropylamine, and sorbitan sesquiolate were significantly more frequent in E‐Group patients than in NE‐Group ones.ConclusionsEyelid dermatitis is a frequent dermatological complaint. Allergic contact dermatitis is the most frequent diagnosis commonly caused by nickel sulphate, isothiazolinones, and fragrances. The surfactants dimethylaminopropylamine and sorbitan sesquioleate are emerging causes of eyelid allergic contact dermatitis.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Contact allergy to SIDAPA baseline series allergens in patients with eyelid dermatitis: An Italian multicentre study

Stingeni,

Foti,

Guarneri

et al. 2024

Contact Dermatitis

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“…Eyelid dermatitis has always been a diagnostic and therapeutic challenge for the dermatologist, as the presence of skin lesions in a visible location has a significant impact on the patient's quality of life and because exposure can lead to continuous interaction with irritating and/or allergenic agents, that contribute to the maintenance of dermatitis [21][22][23][24]. Furthermore, the distinguishing structure of this anatomical region [3], and the thinness of the skin, increases the risk of side effects caused by topical treatments, including poor tolerability and steroid-induced atrophy [25,26].…”

Section: Discussionmentioning

confidence: 99%

A Randomized Controlled Prospective Cohort Study on the Efficacy of a Witch Hazel Extract Cream for the Eyelids and Eye Contour Area and a Cleansing Face Cream in Dermatitis of the Eyelids

Veronese,

Esposto,

Airoldi

et al. 2024

Cosmetics

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Background: Eyelid dermatitis is a common, multifactorial, chronic, and/or relapsing condition with a considerable impact on life quality that represents a diagnostic and treatment challenge. Methods: We carried out a single-blind, controlled, randomized, parallel-group study to evaluate the efficacy of two dermo-cosmetics (cream for the eyelids and eye contour area and cleansing face cream) in which the key ingredient was witch hazel extract, compared to generic cream, in the treatment of patients affected by eyelid dermatitis. Enrolled subjects were treated and followed-up for 4 weeks; dermatological evaluation was objectively performed using the DLQI, OSDI, NRS–itch, and EDSI indicators. Results: The products tested proved to be more effective than the placebo in ameliorating the dermatitis in the treated patients, based on all considered dermatological scores. In the treatment arm, we observed a reduction in both DLQI score and in the indicators related to the extension of dermatitis, greater than that observed in the control arm. Conclusions: This comparative study demonstrates the role of dermo-cosmetic products tested not only as a support treatment, but also as a first-choice clinical approach.

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“…The pathophysiology of allergic contact dermatitis begins with contact of the allergen with the skin. This allergen penetrates the stratum corneum of the skin and contacts Langerhans cells [5][6][7][8]. Langerhans cells then migrate to regional lymph nodes and present captured antigens.…”

Section: Introductionmentioning

confidence: 99%

Allergic Contact Dermatitis: Etiological Matrix

Konovalenko,

Litus,

Litus

2023

ArveMED

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The article discusses the main links of the pathogenesis of allergic contact dermatitis and gives the results of patch testing in patients who were examined to determine the etiological factors of the disease. Screening showed that nickel, cobalt, methylisothiazolinone, phenylenediamine, formaldehydes and fragrances are the most common etiological factors of ACD. Named haptens cause the absolute majority of positive reactions in the selected group of patients, and also cause the largest number of reactions of pronounced intensity. Patch testing is an informative and useful method for a balanced planning in ACD patients treatment strategy, because it reveals the etiological matrix of the pathological process occurrence in the skin.

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Allergic contact dermatitis of the eyelids: An interdisciplinary review

Cited by 6 publications

References 47 publications

Contact allergy to SIDAPA baseline series allergens in patients with eyelid dermatitis: An Italian multicentre study

Contact allergy to SIDAPA baseline series allergens in patients with eyelid dermatitis: An Italian multicentre study

A Randomized Controlled Prospective Cohort Study on the Efficacy of a Witch Hazel Extract Cream for the Eyelids and Eye Contour Area and a Cleansing Face Cream in Dermatitis of the Eyelids

Allergic Contact Dermatitis: Etiological Matrix

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