Abstract:Background:Fentanyl is primarily an opioid agonist. It is frequently used in general anesthe-sia as a potent analgesic. It can be administered either orally, transdermally or systemically. Adverse ef-fects due to opium alkaloids are usually because of a non-specific histamine release. Only in a few cases, a true allergy mechanism could be involved. Immediate reactions to opioids are most frequent than de-layed reactions. In the past years, delayed reactions have increased in frequency because of the wide use o… Show more
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