Allergic Contact Dermatitis to Fragrances: Part 2

Arribas, María Paloma; Soro, Pilar; Silvestre, J.F.

doi:10.1016/j.adengl.2012.11.003

Cited by 10 publications

(15 citation statements)

References 53 publications

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“…In this work, we started to design our approach by considering that fragrances are typically applied at low concentrations (ca. 0.25–5% (w/w)) in toiletries and household product (THP) formulations to avoid allergic reactions, to avoid destabilization of the formulation, and/or due to cost constrains . Consequently, we assumed that the evaporation of each fragrance component present in a multicomponent fragrance mixture dissolved in such a matrix could be calculated from its corresponding Henry’s law constant ( H ) determined when present alone in the matrix for low concentrations.…”

Section: Introductionmentioning

confidence: 99%

Modeling Fragrance Components Release from a Simplified Matrix Used in Toiletries and Household Products

Costa

Teixeira

Lièvre

et al. 2015

Ind. Eng. Chem. Res.

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A new methodology based on Henry’s law is proposed for modeling the release of fragrances from a simplified matrix commonly used in consumer products’ formulations. For that purpose, different mixtures were formulated containing one, two, three, or four fragrance ingredients diluted in dipropylene glycol (simplified matrix). Headspace concentrations were measured to estimate Henry’s constants (H) for each fragrance component in all mixtures. The individual Henry’s constants for multicomponent fragrance mixtures were also predicted from the ones measured for each single compound diluted in the matrix. Furthermore, we used a model that combines the UNIFAC group-contribution method with the modified Raoult’s law and the psychophysicals Stevens’ power law and strongest component model to predict the perceived odor intensity and character, respectively. Results showed a strong linear relationship between experimental H for single fragrances and experimental H for binary (r 2 = 0.998), ternary (r 2 = 0.997), and quaternary (r 2 = 0.996) fragrance mixtures. This new approach can bring a relevant advantage to the preformulation process by reducing time and cost associated with trial-and-error experiments.

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Section: Introductionmentioning

confidence: 99%

Modeling Fragrance Components Release from a Simplified Matrix Used in Toiletries and Household Products

Costa

Teixeira

Lièvre

et al. 2015

Ind. Eng. Chem. Res.

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“…cinnamyl alcohol, cinnamic aldehyde, eugenol, and isoeugenol). Cross-reactions may occur to colophonium and fragrance mix I (22). According to Belloni et al, myroxylon pereirae resin is among the 10 most frequent haptens (20).…”

Section: Discussionmentioning

confidence: 99%

Contact sensitization to ingredients of dental materials and cosmetics in dental students: a pilot study

Lyapina

Dencheva

2019

Cent Eur J Public Health

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Objective: The aim of this study was to evaluate the rate of contact sensitization to selected cosmetic allergens, i.e. ingredients of dental materials, in students of dental medicine and dental patients.Methods: A total of 50 participants were included in the study: 40 students of dental medicine exposed to the studied allergens during the course of practical education; and 10 randomly selected dental patients without occupational exposure to the investigated substances served as a control group. All of them were patch-tested with colophonium, myroxylon pereirae resin, paraben mix, fragrance mix I, isopropyl myristate, triclosan, polysorbate 80, compositae mix II, and hydroperoxides of limonene.Results: The sensitization rates for colophonium and polysorbate 80 were the highest. For the group of dental students, we established significantly higher sensitization rate for colophonium compared to the ones for myroxylon pereirae resin and hydroperoxides of limonene (χ 2 = 4.93; p = 0.026), paraben mix (χ 2 = 3.6; p = 0.05), isopropyl myristate (χ 2 = 6.56; p = 0.01), and triclosan (χ 2 = 8.5; p < 0.001); and to polysorbate 80 compared to the ones for myroxylon pereirae resin and hydroperoxides of limonene (χ 2 = 3.97; p = 0.046), isopropyl myristate (χ 2 = 5.47; p = 0.02) and triclosan (χ 2 = 7.34; p = 0.007). Significantly increased concomitant sensitization rate to compositae mix and to hydroperoxides of limonene was established (χ 2 = 12.55; p < 0.001). Generally, the incidence of concomitant sensitization to the studied allergens in the whole studied population was high.Conclusions: Colophonium and polysorbate 80 could be outlined as sensitizers of paramount importance for both dental students and dental patients. We consider the major importance of exposure to colophonium during the course of practical education in dentistry for the onset of the sensitization. Sensitization to compositae mix was observed only among dental students. We consider the leading role of consumer exposure for the onset of the sensitization to triclosan and to hydroperoxides of limonene. Unexpected and unreported reactions of concomitant sensitization were observed.

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“…A number of fragrance ingredients represent an important cause of contact allergy in consumers [1][2][3][4][5][6][7]. Among these is a chemical with the INCI name hydroxyisohexylcyclohexene carboxaldehyde, but this has not been discussed in detail here because its use in household products is very low (approx.…”

Section: Discussionmentioning

confidence: 99%

“…Key words: allergic contact dermatitis, contact allergy, detergents, fragrances, household cleaning products, quantitative risk assessment T he world of chemistry contains a minority, but toxicologically important, category of substances, of either natural or synthetic origin, which possess the intrinsic capacity to cause sensitisation by skin contact [1,2]. Prominent among the causative chemicals are organic molecules whose olfactory properties render them valuable as fragrances, but which also possess the capacity to induce contact allergy and to elicit allergic contact dermatitis (ACD) [3][4][5][6][7]. Consequently, it is essential that potential fragrance allergen hazards are identified and the risk that they present to human health is properly assessed and that that risk is adequately managed.…”

mentioning

confidence: 99%

Skin sensitisation to fragrance ingredients: is there a role for household cleaning/maintenance products?

Basketter¹,

Lemoine²,

McFadden³

2015

European Journal of Dermatology

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Allergic Contact Dermatitis to Fragrances: Part 2

Cited by 10 publications

References 53 publications

Modeling Fragrance Components Release from a Simplified Matrix Used in Toiletries and Household Products

Modeling Fragrance Components Release from a Simplified Matrix Used in Toiletries and Household Products

Contact sensitization to ingredients of dental materials and cosmetics in dental students: a pilot study

Skin sensitisation to fragrance ingredients: is there a role for household cleaning/maintenance products?

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