Allergic contact dermatitis to iodopropynyl butylcarbamate found in a cosmetic cleansing wipe

Contact allergy to preservatives. Analysis of IVDK data 1996-2009

“…According to a source from North America, IPBC was present in 5AE5% of shampoos. 53 Lacking a probable alternative explanation, notwithstanding single case reports, 54 our first interpretation of IPBC being a sensitizer substantially through occupational exposure thus seems justified. [55][56][57][58] A similar, but not identical, reasoning may apply to the case of MI.…”

Potential Allergens in Disposable Diaper Wipes, Topical Diaper Preparations, and Disposable Diapers

“…49 It has low sensitization risk and allergic reactions are uncommon, 50 but IPBC has been implicated in ACD because of baby wipes 51 and cosmetic removal wipes. 52 Patch testing to IPBC in children only showed a 0.6% positivity in children younger than 18 years; in children younger 5 years, IPBC did not cause any RPPT reaction. 5 Although the sensitization risk to IPBC is higher in leave-on products, 53 we did not identify any topical preparations with IPBC.…”

Contact-Allergic Reactions to Cosmetics

“…This is often the case also for, for example, mefenesin, a rubefacient in topical pharmaceutical products, which cross-reacts with chlorphenesin, used as a preservative agent in cosmetics (data on file) and thus a potential sensitizing agent [19]. A further recently introduced preservative is iodopropynyl butylcarbamate, also present in baby and make-up cleansing wipes [20], first reported as a cosmetic allergen by Pazzaglia and Tosti in 1999 [21]. Its presence in cosmetics is being discussed, not because of its potentially allergenic properties, but because of its iodine content.…”