Allergic Disease Epidemiology

Wang, Juan; Wu, Junshu; Lai, He

doi:10.1007/978-94-017-7444-4_2

Cited by 8 publications

(3 citation statements)

References 85 publications

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“…The frequency of allergic diseases is also increasing rapidly, particularly in developed countries [68]. Early-life antibiotic exposure or a dysregulated microbiota has been linked with allergen sensitisation [65].…”

Section: Using Glycosyltransferase Characteristics To Inform Policy Amentioning

confidence: 99%

Infection’s Sweet Tooth: How Glycans Mediate Infection and Disease Susceptibility

Taylor

McGuckin

Wesselingh

et al. 2018

Trends in Microbiology

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Glycans form a highly variable constituent of our mucosal surfaces and profoundly affect our susceptibility to infection and disease. The diversity and importance of these surface glycans can be seen in individuals who lack a functional copy of the fucosyltransferase gene, FUT2. Representing around one-fifth of the population, these individuals have an altered susceptibility to many bacterial and viral infections and diseases. The mediation of host-pathogen interactions by mucosal glycans, such as those added by FUT2, is poorly understood. We highlight, with specific examples, important mechanisms by which host glycans influence infection dynamics, including by: acting as pathogen receptors (or receptor-decoys), promoting microbial stability, altering the physical characteristics of mucus, and acting as immunological markers. We argue that the effect glycans have on infection dynamics has profound implications for many aspects of healthcare and policy, including clinical management, outbreak control, and vaccination policy.

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Section: Using Glycosyltransferase Characteristics To Inform Policy Amentioning

confidence: 99%

Infection’s Sweet Tooth: How Glycans Mediate Infection and Disease Susceptibility

Taylor

McGuckin

Wesselingh

et al. 2018

Trends in Microbiology

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“…[ 3 , 4 , 5 , 6 , 7 ]. They have been described as disorders that are a result of IgE-mediated hypersensitivity, though the underlying mechanism still remains vague [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Allergy and Household Living Conditions among Adolescents Living near Gold Mine Tailing Dumps in the Gauteng and North West Provinces of South Africa

Olajide-Ibiejugba

Nkosi

Rathogwa-Takalani

et al. 2021

IJERPH

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This quantitative exploratory baseline study aimed to investigate whether allergy among adolescents was associated with household living conditions, including living near gold mine tailing dumps in South Africa. A questionnaire based on the International Study of Asthma and Allergies was used to collect information on allergy and household risk factors among adolescents (n = 5611). A chi-square test was applied to determine the relationship between community (exposed/unexposed) and confounding variables. Crude and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated using univariate and multiple logistic regression analysis (LRA) to estimate the likelihood of having doctor-diagnosed allergies. The overall prevalence of doctor-diagnosed allergies was 25.5%. The exposed communities had a higher prevalence of doctor-diagnosed allergies (26.97%) compared with the unexposed (22.69%) communities. The study found an association between doctor-diagnosed allergy and having fungus in the house, being female, currently having pets in and around the house, residing in the community for more than three years and living in communities located close to gold mine tailing dumps. Actions to implement buffer zones between gold mine tailing dumps and communities would support Sustainable Development Goals 3 (health) and 11 (sustainable cities and communities), while failing to address the current potential identified risk factors may pose a significant public health challenge. Local policymakers should also apply the precautionary principle to protect the health of children, especially with the location of human settlements relative to air pollution sources.

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“…Over the last twenty years, the percentage of the population affected by inhalant allergies has increased around the world, particularly noted in industrialized countries (Kobayashi et al 2009;Wang et al 2015;Vianello et al 2016). World Allergy Organization (WAO) White Book on Allergy (Pawankar et al 2013), confirms that the incidence of asthma and rhinitis is increasing across the globe, and that this increase is in both industrialized and developing countries (Pawankar et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Molecular diversity and allergenic profiles of Alternaria spp. from desert environments in Arizona

et al. 2018

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This study examined the genetic diversity of small-spored Alternaria species in the southwest desert of the USA by sampling 552 isolates from different habitats (soil and plant debris) in different locations (urban and an undisturbed desert). To estimate the genetic diversity, Amplified Fragment Length Polymorphism (AFLP) fingerprinting analysis was performed for all isolates. Strains representative of the sampled genotypic diversity (n = 125) were further characterized according their sporulation pattern and the capability to produce allergens. Morphological characterization assigned the majority of the strains to the Alternaria alternata and Alternaria tenuissima morpho-groups with only two isolates assigned to the Alternaria arborescens morpho-group. AFLP fingerprinting differentiated the A. arborescens morpho-groups, but could not distinguish between the A. alternata and A. tenuissima morpho-groups. Western blot analysis showed that a large number of allergenic proteins were produced by strains. These proteins were not specific for any morpho-group nor source of isolation. A hierarchical analysis of molecular variance was performed on the AFLP data to quantify molecular variation and partition this variation among sampled locations and habitat. No statistically significant differentiation among locations and habitat was detected indicating a lack of population structure across environments.

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Allergic Disease Epidemiology

Cited by 8 publications

References 85 publications

Infection’s Sweet Tooth: How Glycans Mediate Infection and Disease Susceptibility

Infection’s Sweet Tooth: How Glycans Mediate Infection and Disease Susceptibility

Allergy and Household Living Conditions among Adolescents Living near Gold Mine Tailing Dumps in the Gauteng and North West Provinces of South Africa

Molecular diversity and allergenic profiles of Alternaria spp. from desert environments in Arizona

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