Allergic diseases and asthma in relation to serum immunoglobulins and salivary immunoglobulin A in pre‐school children: a follow‐up community‐based study

Lúðvíksson, Björn Rúnar; Arason, G J; Thorarensen, Ólafur; Árdal, Björn; Valdimarsson, H.

doi:10.1111/j.1365-2222.2005.02141.x

Cited by 35 publications

(46 citation statements)

References 36 publications

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“…These results are consistent with those of previous studies [2,4-6,10] showing that low IgA level is associated with atopic disease. The subjects of previous studies [2,4-6] were mainly children, and some authors have found that the atopy/IgA relationship was unclear in adult patients [7]. However, a study in adult patients by Balzar et al [10] revealed a relationship between serum IgA level and asthma severity.…”

Section: Discussionsupporting

confidence: 94%

“…In addition, infants born to atopic parents had a higher prevalence of salivary IgA deficiency [5]; children with positive skin prick tests to common allergens had lower serum IgA levels; and children who developed allergic rhinitis or atopic eczema had lower salivary IgA levels [6]. …”

Section: Introductionmentioning

confidence: 99%

“…During early life, when the human immune system is immature, impaired IgA responses may facilitate sensitization to allergens and the development of allergic diseases. Therefore, the subjects of many studies on IgA/ allergy were infants or children [2,4-6]. In adulthood, IgA levels may be restored to normal and reduced IgA levels in nasal washes of adult asthmatics were not evident in one study [7].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between serum IgA level and allergy/asthma

Kim

Choi

Kim

et al. 2017

Korean J Intern Med

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Background/AimsMucosal immunoglobulin A (IgA) may prevent the entrance of allergens. This study examined the relationship between serum IgA levels (within the normal range) and sensitization to house dust mites (HDM) or airway hyper-responsiveness (AHR).MethodsThe clinical records of 1,136 adult patients with suspected asthma, for whom test data for serum IgA level and methacholine-AHR were available, were reviewed retrospectively. The AHR/allergy indices were compared among patient groups with low (<140 mg/dL, group I), intermediate (140 to 280 mg/dL, group II), or high (≥280 mg/dL, group III) IgA levels in serum.ResultsThe HDM skin sensitization rate progressively decreased from 30.0% in group I (n = 139) to 26.8% and 18.5% in groups II (n = 684) and III (n = 313), respectively (p = 0.003). Although both the HDM sensitization degree and the IgA level were significantly related to age, the adjusted odds ratio (OR) of association of a high IgA level (≥ 280 mg/dL) with HDM sensitization was significant (0.617; 95% confidence interval [CI], 0.415 to 0.916; p = 0.017). Among younger subjects (≤ 45 years of age) with AHR, the prevalence of moderate/severe AHR progressively decreased (70.6%, 52.3%, and 47.1% in groups I, II, and III [n = 34, 149, and 51]), respectively (p = 0.045). The IgA < 140 mg/dL was a significant risk factor for moderate/severe AHR (OR, 2.306; 95% CI, 1.049 to 5.071; p = 0.038).ConclusionsSensitization to HDM and methacholine-AHR were significantly associated with serum IgA levels in suspected asthmatics, even when those levels were normal.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship between serum IgA level and allergy/asthma

Kim

Choi

Kim

et al. 2017

Korean J Intern Med

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“…Elevated IgE and IgA levels in the BALF of T-bet Ϫ/Ϫ mice likely reflect persistent stimulation of the respiratory mucosa by M. pulmonis. Elevated IgA levels also are associated with the asthmatic phenotype and AHR (50,51). IgG2b Abs play a major role in the clearance of M. pulmonis, and failure to mount an IgG2b response is associated with increased disease susceptibility (52,53).…”

Section: Discussionmentioning

confidence: 99%

T-bet Deficiency Facilitates Airway Colonization byMycoplasma pulmonisin a Murine Model of Asthma

Bakshi

Malik

Carrico³

et al. 2006

The Journal of Immunology

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Epidemiological and clinical evidence suggest a correlation between asthma and infection with atypical bacterial respiratory pathogens. However, the cellular and molecular underpinnings of this correlation remain unclear. Using the T-bet-deficient (T-bet−/−) murine model of asthma and the natural murine pathogen Mycoplasma pulmonis, we provide a mechanistic explanation for this correlation. In this study, we demonstrate the capacity of asthmatic airways to facilitate colonization by M. pulmonis and the capacity of M. pulmonis to exacerbate symptoms associated with acute and chronic asthma. This mutual synergism results from an inability of T-bet−/− mice to mount an effective immune defense against respiratory infection through release of IFN-γ and the ability of M. pulmonis to trigger the production of Th2-type cytokines (e.g., IL-4 and IL-5), and Abs (e.g., IgG1, IgE, and IgA), eosinophilia, airway remodeling, and hyperresponsiveness; all pathophysiological hallmarks of asthma. The capacity of respiratory pathogens such as Mycoplasma spp. to dramatically augment the pathological changes associated with asthma likely explains their association with acute asthmatic episodes in juvenile patients and with adult chronic asthmatics, >50% of whom are found to be PCR positive for M. pneumoniae. In conclusion, our study demonstrates that in mice genetically predisposed to asthma, M. pulmonis infection elicits an inflammatory milieu in the lungs that skews the immune response toward the Th2-type, thus exacerbating the pathophysiological changes associated with asthma. For its part, airways exhibiting an asthmatic phenotype provide a fertile environment that promotes colonization by Mycoplasma spp. and one which is ill-equipped to kill and clear respiratory pathogens.

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“…Low sIgA have been associated with atopic eczema (13). In children with chronic airways diseases there was only a slight increase of secretory IgA during the first 4 years of live (14).…”

Section: Introductionmentioning

confidence: 99%