Allergic diseases in the elderly

Abstract

Recent increases in allergic diseases are thought to be caused by better hygiene, Westernized diets, air pollution, climate change, and other factors that influence host microbiota, a key player in the induction and maintenance of immunoregulatory circuits and tolerance. The increase of allergic diseases in the elderly is also related to additional factors, such as various comorbidities that may interfere with the development and the type of allergic reactions. Immunosenescence plays a central role in these reactions, altering microbiota responses and triggering inflammageing. In addition, in the elderly, there is a shift from Th1 to Th2 immunity, thus favoring allergic responses. A better understanding of the mechanisms responsible for immunosenescence and its effects on allergic inflammation will most certainly lead to improved therapies.

Use of omalizumab and allergen-specific immunotherapy for the treatment of respiratory allergic diseases in children and adults

“…2024; 2: 38-49. https://doi.org/10.53529/2500-1175-2024-2-38-49 ВВЕДЕНИЕ В настоящее время количество и тяжесть течения аллергических заболеваний и в том числе респираторных аллергических болезней (аллергического ринита, бронхиальной астмы) неуклонно возрастает. Это показано во многих работах, в различных регионах мира [1][2][3][4][5]. В данных условиях особенно актуальными становятся методы лечения и профилактики, способные улучшить течение аллергического заболевания, обеспечить предупреждение его, прекращение прогрессирования аллергического процесса, развитие его осложнений.…”