Allergic gastrointestinal motility disorders in infancy and early childhood

Heine, Ralf G.

doi:10.1111/j.1399-3038.2008.00785.x

Cited by 53 publications

(43 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Eosinophilic esophagitis has recently been identified as another condition closely related to food allergy, particularly in children [136]. Symptoms of gastrointestinal food allergy include persistent diarrhea, rectal bleeding, vomiting, failure to thrive, irritable behavior, and feeding difficulties [137,138]. These conditions are caused by non-IgE-mediated mechanisms and are generally characterized by noninfective gastrointestinal inflammation with an increase in mucosal T lymphocytes, eosinophils, mast cells, or basophils.…”

Section: Probiotics and Allergic Gastrointestinal Diseasementioning

confidence: 99%

Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position Paper

Fiocchi

Burks

Bahna

et al. 2012

World Allergy Organization Journal

Self Cite

124

View full text Add to dashboard Cite

BackgroundProbiotic administration has been proposed for the prevention and treatment of specific allergic manifestations such as eczema, rhinitis, gastrointestinal allergy, food allergy, and asthma. However, published statements and scientific opinions disagree about the clinical usefulness.ObjectiveA World Allergy Organization Special Committee on Food Allergy and Nutrition review of the evidence regarding the use of probiotics for the prevention and treatment of allergy.MethodsA qualitative and narrative review of the literature on probiotic treatment of allergic disease was carried out to address the diversity and variable quality of relevant studies. This variability precluded systematization, and an expert panel group discussion method was used to evaluate the literature. In the absence of systematic reviews of treatment, meta-analyses of prevention studies were used to provide data in support of probiotic applications.ResultsDespite the plethora of literature, probiotic research is still in its infancy. There is a need for basic microbiology research on the resident human microbiota. Mechanistic studies from biology, immunology, and genetics are needed before we can claim to harness the potential of immune modulatory effects of microbiota. Meanwhile, clinicians must take a step back and try to link disease state with alterations of the microbiota through well-controlled long-term studies to identify clinical indications.ConclusionsProbiotics do not have an established role in the prevention or treatment of allergy. No single probiotic supplement or class of supplements has been demonstrated to efficiently influence the course of any allergic manifestation or long-term disease or to be sufficient to do so. Further epidemiologic, immunologic, microbiologic, genetic, and clinical studies are necessary to determine whether probiotic supplements will be useful in preventing allergy. Until then, supplementation with probiotics remains empirical in allergy medicine. In the future, basic research should focus on homoeostatic studies, and clinical research should focus on preventive medicine applications, not only in allergy. Collaborations between allergo-immunologists and microbiologists in basic research and a multidisciplinary approach in clinical research are likely to be the most fruitful.

show abstract

Section: Probiotics and Allergic Gastrointestinal Diseasementioning

confidence: 99%

Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position Paper

Fiocchi

Burks

Bahna

et al. 2012

World Allergy Organization Journal

Self Cite

124

View full text Add to dashboard Cite

show abstract

“…Infant colic (more than 3 hours of crying a day, 3 days for more than 3 weeks) is not unanimously considered as a consequence of CMPA. The paediatrician has to consider the opportunity of a cow's milk free diet in the most troublesome cases [26,27]. Mild immediate reactions may be of difficult interpretation because they can be the result of causes different from CMPA.…”

Section: A Child Fed With Cow's Milk Formula With Mild- Moderate Sympmentioning

confidence: 99%

Cow's milk protein allergy in children: a practical guide

et al. 2010

View full text Add to dashboard Cite

A joint study group on cow's milk allergy was convened by the Emilia-Romagna Working Group for Paediatric Allergy and by the Emilia-Romagna Working Group for Paediatric Gastroenterology to focus best practice for diagnosis, management and follow-up of cow's milk allergy in children and to offer a common approach for allergologists, gastroenterologists, general paediatricians and primary care physicians.The report prepared by the study group was discussed by members of Working Groups who met three times in Italy. This guide is the result of a consensus reached in the following areas. Cow's milk allergy should be suspected in children who have immediate symptoms such as acute urticaria/angioedema, wheezing, rhinitis, dry cough, vomiting, laryngeal edema, acute asthma with severe respiratory distress, anaphylaxis. Late reactions due to cow's milk allergy are atopic dermatitis, chronic diarrhoea, blood in the stools, iron deficiency anaemia, gastroesophageal reflux disease, constipation, chronic vomiting, colic, poor growth (food refusal), enterocolitis syndrome, protein-losing enteropathy with hypoalbuminemia, eosinophilic oesophagogastroenteropathy. An overview of acceptable means for diagnosis is included. According to symptoms and infant diet, three different algorithms for diagnosis and follow-up have been suggested.

show abstract

“…Allergic GI motility disorders are common in infancy and early childhood 51. Symptoms are shared by many IgE and non-IgE CMP-induced disorders 40.…”

Section: Immune-mediated Reactions To Cow's Milkmentioning

confidence: 99%

Identifying and managing cow's milk protein allergy

Toit

Shah

Heine

et al. 2010

Archives of Disease in Childhood - Education and Practice

View full text Add to dashboard Cite

Cow's milk protein (CMP) is usually one of the first complementary foods to be introduced into the infant's diet and is commonly consumed throughout childhood as part of a balanced diet. CMP is capable of inducing a multitude of adverse reactions in children, which may involve organs like the skin, gastrointestinal (GI) tract or respiratory system. The diagnosis of CMP-induced adverse reactions requires an understanding of their classification and immunological basis as well as the strengths and limitations of diagnostic modalities. In addition to the well-recognised, immediate-onset IgE-mediated allergies, there is increasing evidence to support the role of CMP-induced allergy in a spectrum of delayed-onset disorders ranging from GI symptoms to chronic eczema. The mainstay of treatment is avoidance of CMP; this requires dietetic input to ensure that this does not lead to any nutritional compromise. This review is intended to highlight the broad spectrum of manifestations of CMP allergy and to offer an approach to the diagnosis and treatment thereof.

show abstract

Allergic gastrointestinal motility disorders in infancy and early childhood

Cited by 53 publications

References 68 publications

Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position Paper

Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position Paper

Cow's milk protein allergy in children: a practical guide

Identifying and managing cow's milk protein allergy

Contact Info

Product

Resources

About