Allergic Reaction Following Arachnoid Plasty With a Fibrin Sealant  -Case Report-

Kanazawa, Ryuzaburo; Sato, Shun; Iwamoto, Naotaka; Teramoto, Akira

doi:10.2176/nmc.50.608

Cited by 30 publications

(29 citation statements)

References 11 publications

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“…1,8,13 However, an allergic reaction was reported after arachnoid plasty using a fibrin sealant, and the overall benefits and risks of such procedures have not yet been ascertained based on a large case series. 9 The current study is limited, because it is based on a retrospective review of a case series from a single institution. However, the large number of patients and strict radiological follow-up of the subdural complications until their resolution allow for a high level of confidence in the identified risk factors and final outcomes.…”

Section: Discussionmentioning

confidence: 99%

Postoperative subdural hygroma and chronic subdural hematoma after unruptured aneurysm surgery: age, sex, and aneurysm location as independent risk factors

Park¹,

Cho²,

Goh³

et al. 2016

JNS

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Section: Discussionmentioning

confidence: 99%

Postoperative subdural hygroma and chronic subdural hematoma after unruptured aneurysm surgery: age, sex, and aneurysm location as independent risk factors

Park¹,

Cho²,

Goh³

et al. 2016

JNS

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“…7,8 However, fibrin glue is used along with a synthetic substance such as aprotinin, fibrinogen, and thrombin to create a fibrin clot; therefore, the fibrin glue carries the risk of unknown viral transfer, or the patient may develop an anaphylactic reaction to aprotinin. 4,9,17,18 Recently, a PEG hydrogel sealant was developed to achieve a watertight dural closure. 15,16 A PEG hydrogel sealant eliminates the risk of viral transmission and reduces the risk of allergic reactions.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of fibrin and chemical synthetic sealant on dural regeneration and brain damage

Itō¹,

Horiuchi²,

Oyanagi³

et al. 2013

SPI

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Object Several materials, such as polyethylene glycol (PEG) hydrogel and fibrin glue, have been used to seal dural incisions after brain and spinal surgeries. Although the use of PEG sealant is gaining popularity, it can be associated with postoperative cerebrospinal fluid leakage and infection. However, the reasons for this association are currently unknown. The present study aimed to investigate the effects of PEG sealant and fibrin glue on wound healing and brain damage in vivo. Methods Oval-shaped bone defects and dural defects were created bilaterally over the parietal lobes of 22 Japanese white rabbits. The dural defects were covered with 0.5 ml of fibrin glue on one side and 0.5 ml of PEG sealant on the other side. Dural regeneration and brain damage were investigated in each harvested brain and dura mater using light microscopy. Results Dural regeneration was more effective in the presence of fibrin glue than it was with PEG sealant (p = 0.014). Of the 22 rabbits, 11 showed thick (Grades ++ and +++) dural regeneration by 28 days postsurgery in the hemisphere where fibrin glue was used, whereas Grade +++ dural regeneration was not observed in the PEG hydrogel hemisphere, and only 4 rabbits showed Grade ++ regeneration. Abscess and granulation formation also tended to be more severe when PEG hydrogel sealant was used. No Grade ++ granulation/abscess formation was observed with fibrin glue, and Grade + was only observed in 13 of 22 rabbits. Conversely, with PEG hydrogel sealant, only 2 rabbits did not show granulation/abscess formation, and Grade +, ++, and +++ granulation/abscess formation was observed in 8, 7, and 5 rabbits, respectively. The extent of cortical damage was significantly greater in rabbits with abscesses and granulations, compared with rabbits without these lesions (p = 0.007). Conclusions Dural regeneration tended to occur more rapidly with fibrin glue, whereas granulation was more likely with PEG hydrogel sealant, which led to postoperative complications. Histological analysis indicated that PEG hydrogel sealant inhibited the normal tissue healing process and that outcomes were improved by the use of fibrin glue.

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“…humans, in and on the cerebral surface and nerves with only few adverse events indicate that its use is safe and well tolerated (4,6,12,15,16,19,22,24,25,27).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Minimizing Collateral Brain Injury Using a Protective Layer of Fibrin Glue: Technical Note

et al. 2015

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Allergic Reaction Following Arachnoid Plasty With a Fibrin Sealant -Case Report-

Cited by 30 publications

References 11 publications

Postoperative subdural hygroma and chronic subdural hematoma after unruptured aneurysm surgery: age, sex, and aneurysm location as independent risk factors

Postoperative subdural hygroma and chronic subdural hematoma after unruptured aneurysm surgery: age, sex, and aneurysm location as independent risk factors

Comparative study of fibrin and chemical synthetic sealant on dural regeneration and brain damage

Minimizing Collateral Brain Injury Using a Protective Layer of Fibrin Glue: Technical Note

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