Allergic Reactions Due to Ibuprofen in Children

Jara, Margarita; Montero, Alina; Bara, María Teresa Gracia; Cabrerizo, S.; Zapatero, L.; Molero, M. I. Martínez

doi:10.1046/j.1525-1470.2001.018001066.x

Cited by 28 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the level of case reports or specific cases within reported case series, we have found documentation of the following clinical presentations in children less than 6 years of age: in the group of nonspecific, cross-reactive, most likely COX inhibitor-dependent reactions, cases of cross-reactive AERD [9-12,32], cross-reactive angioedema/urticaria in children with chronic urticaria [33-37], cross-reactive angioedema/urticaria in children without chronic urticaria1[5,38-40] and mixed reactions, i.e. angioedema/urticaria and acute respiratory symptoms, bronchospasm has been documented [15,41].…”

Section: Resultsmentioning

confidence: 99%

“…In the group of drug-specific, most likely immune-mediated reactions, published cases were found detailing immediate single drug-mediated urticaria/angioedema [38,42] and cases of delayed-type hypersensitivity reactions, that is, fixed drug eruptions and toxic epidermal necrolysis [38,43-46]. No publications of ASA- or NSAID-induced aseptic meningitis or hypersensitivity pneumonitis were identified in the studied age group.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Preschool Children

Kidon

Kang

Chin

et al. 2007

All Asth Clin Immun

View full text Add to dashboard Cite

Although extensively studied in adults, nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity in children, especially in young children, remains poorly defined. Pediatricians, prescribing antipyretics for children, rarely encounter significant problems, but the few epidemiologic studies performed show conflicting results. Although it is clear that some patients with acetylsalicylic acid (ASA)-sensitive asthma have their clinical onset of disease in childhood and bronchoconstriction after ASA challenge is seen in 0 to 22% of asthmatic children so challenged, ibuprofen at antipyretic doses may cause acute respiratory problems only in a very small number of mild to moderate asthmatics. The recently elucidated mechanism of action of acetaminophen may explain some occurrences of adverse reactions in patients with cross-reactive NSAID hypersensitivity on the basis of its inhibitory activity on the newly described enzyme, cyclooxygenase (COX)-3. This nonspecific sensitivity to inhibition of COX is most likely genetically determined and shows a remarkable association with atopic disease even in the very young age group and possibly an increased predilection in specific ethnic groups. This review summarizes state-of-the-art published data on NSAID hypersensitivity in preschool children.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Preschool Children

Kidon

Kang

Chin

et al. 2007

All Asth Clin Immun

View full text Add to dashboard Cite

show abstract

“…Therefore it is not surprising that paediatric patients are exposed to a rate of potentially dangerous medication errors three times higher than that for adult patients (23). However, only a small proportion of these medication errors will lead to ADRs and be recognized as such.…”

Section: Other Areasmentioning

confidence: 99%

“…There have been recent reports of significant ADRs to ibuprofen in children primarily as a result of its availability as an over-thecounter preparation (23,24). The predominant reactions were rash (acute urticaria, fixed medicine eruption), gastrointestinal and respiratory side-effects, and even haematemesis.…”

Section: Anti-pyretic and Anti-inflammatory Medicinesmentioning

confidence: 99%

Untitled

2016

IJPSR

View full text Add to dashboard Cite

“…Reports on topical provocation with naproxen and metamizol, two nonsteroidal anti-inflammatory drugs (NSAIDs), are very rare in the literature. [1][2][3][4][5][6] The aim of this open prospective study was to investigate the usefulness of topical provocation in the diagnosis of naproxen-and metamizol-induced FDE and its correlation with oral provocation.…”

Section: Reportmentioning

confidence: 99%

Topical provocation in fixed drug eruption due to metamizol and naproxen

Özkaya‐Bayazit

2004

Clin Exp Dermatol

View full text Add to dashboard Cite

The aim of this study was to investigate the usefulness of topical provocation in the diagnosis of metamizol- and naproxen-induced fixed drug eruption (FDE). Five patients with metamizol- and four patients with naproxen-induced FDE established by oral provocation were tested with the causative drugs at concentrations of 10%, 20%, and 50% in white petrolatum both on previously involved and uninvolved skin using the occlusive patch test technique. Additionally, four patients with metamizol- and five patients with naproxen-induced FDE, and 20 healthy controls were tested openly with drug preparations in dimethyl sulfoxide (DMSO). Tape-stripping occlusive patch testing in petrolatum remained negative in all. Open testing with drug preparations in DMSO revealed positive results in all four patients tested with metamizol mainly at concentrations of 20%, and in three of five patients tested with naproxen exclusively at concentrations of 50%. No positive reaction was seen on previously uninvolved skin and in healthy controls with any drug concentration and pure DMSO. In conclusion, repeated open testing with concentrations of the drugs up to 50% in DMSO seems to be a reliable test method in metamizol-induced FDE whereas oral provocation is still the most reliable method for naproxen-induced FDE as false negative results were common when testing topically with naproxen.

show abstract

Allergic Reactions Due to Ibuprofen in Children

Cited by 28 publications

References 7 publications

Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Preschool Children

Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Preschool Children

Untitled

Topical provocation in fixed drug eruption due to metamizol and naproxen

Contact Info

Product

Resources

About