Allergic reactions to enzymes used in plant cloning experiments

Ransom, James H.; Schuster, Michael

doi:10.1016/0091-6749(81)90088-9

Cited by 10 publications

(7 citation statements)

References 4 publications

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“…Cellulases derived from these fungi are used in baking to break up roughage in dough and as a digestive aid in the food industry [13, 79, 80]. The first case of OA caused by cellulase was reported in 1981 in a plant pathologist [49, 81], and later these findings were confirmed in two pharmaceutical workers [80], four laboratory workers [14], and two bakers [49]. In each of these studies, the workers had specific IgE to the cellulase antigens.…”

Section: Fungal Enzyme Allergensmentioning

confidence: 99%

Industrial Fungal Enzymes: An Occupational Allergen Perspective

Green

Beezhold

2011

Journal of Allergy

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Occupational exposure to high-molecular-weight allergens is a risk factor for the development and pathogenesis of IgE-mediated respiratory disease. In some occupational environments, workers are at an increased risk of exposure to fungal enzymes used in industrial production. Fungal enzymes have been associated with adverse health effects in the work place, in particular in baking occupations. Exposure-response relationships have been demonstrated, and atopic workers directly handling fungal enzymes are at an increased risk for IgE-mediated disease and occupational asthma. The utilization of new and emerging fungal enzymes in industrial production will present new occupational exposures. The production of antibody-based immunoassays is necessary for the assessment of occupational exposure and the development of threshold limit values. Allergen avoidance strategies including personal protective equipment, engineering controls, protein encapsulation, and reduction of airborne enzyme concentrations are required to mitigate occupational exposure to fungal enzymes.

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Section: Fungal Enzyme Allergensmentioning

confidence: 99%

Industrial Fungal Enzymes: An Occupational Allergen Perspective

Green

Beezhold

2011

Journal of Allergy

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“…Follow-up tests were carried out to determine whether the intervention had becn sufficient to prevent new cases. The studies were perforlned in 1991-1993. gies to, for example, alpha-amylase and cellulase (8,9).…”

mentioning

confidence: 99%

Sensitization to industrial enzymes in enzyme research and production

Vanhanen¹,

Tuomi²,

Nordman³

et al. 1997

Scand J Work Environ Health

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“…Although it is clinically impossible to differentiate protein contact dermatitis caused by type I allergy reaction from delayed type IV allergy reaction, the positive patch test reactions confirmed the delayed type allergy in patients 2 and 4. Enzymes can cause different types of allergy (5)(6)(7)(8)(9)(10)(11)(12)(18)(19)(20). Type I. type HI and type IV allergy caused by alpha-amylase used as a dough additive has been described in a baker [13].…”

Section: Discussionmentioning

confidence: 99%

“…14 19]. Few reports on allergic reactions caused by cellulases have been published [12,20], although cellulase has a long history of use in digestive aids and in the foods industry [12]. Here we report the cases of four patients who developed allergic respiratory and skin symptoms after occupational exposure to celtulase or xytanase.…”

Section: Introductionmentioning

confidence: 95%

Allergy from cellulase and xylanase enzymes

Tarvainen

Kanerva

Túpasela

et al. 1991

Clin Experimental Allergy

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Modern biotechnical methods have enabled production of many new types of potentially allergenic proteins. Enzymes have long been known to be respiratory allergens, but relatively few cases of skin allergy have been reported. Here we describe four patients who developed occupational allergic respiratory symptoms, three with bronchial asthma and one with allergic rhinitis, caused by cellulase and/or xylanase enzymes. Each patient also had urticarial symptoms after skin contact with these enzymes. In addition, one of the patients had allergic contact dermatitis from cellulase, and one from xylanase. Allergic contact dermatitis was verified by positive patch tests with the enzymes, and the immediate allergy was revealed by skin prick tests, specific IgE determinations (RAST) and RAST-inhibition tests. All patients had positive RASTs to both cellulase and xylanase. In the RAST inhibition test 20 microliters of cellulase brought about a 94% inhibition, indicating the specificity of the RAST. Xylanase (20 microliters, 5% w/v) gave an 92% inhibition of cellulase RAST, indicating cross-reactivity between cellulase and xylanase. Three patients have been able to continue at their previous places of work, but at different worksites. One of the patients requires continuous medication for asthma and had to change her job because of persistent symptoms.

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Allergic reactions to enzymes used in plant cloning experiments

Cited by 10 publications

References 4 publications

Industrial Fungal Enzymes: An Occupational Allergen Perspective

Industrial Fungal Enzymes: An Occupational Allergen Perspective

Sensitization to industrial enzymes in enzyme research and production

Allergy from cellulase and xylanase enzymes

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