Allergic rhinitis and associated risk of migraine among children: a nationwide population‐based cohort study

Wang, I-Chung; Tsai, Jeng-Dau; Lin, Cheng‐Li; Shen, Te Chun; Li, Tsai‐Chung; Wei, Chang-Ching

doi:10.1002/alr.21654

Cited by 18 publications

(14 citation statements)

References 44 publications

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“…In a univariate analysis, we also found a negative association between allergic rhinitis or conjunctivitis and migraine. This is inconsistent with previous studies that found a positive association in adults or children . Previous studies in children presented methodological limitations that may have biased the conclusions, in particular variability in the diagnosis of allergic rhinitis and possible recall bias.…”

Section: Discussioncontrasting

confidence: 90%

Association Between Migraine and Atopic Diseases in Childhood: A Potential Protective Role of Anti‐Allergic Drugs

et al. 2017

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Persistent childhood asthma was associated with increased risk of migraine and higher frequency of migraine attacks. History of anti-asthmatic or anti-allergic therapies was associated with decreased risk of migraine in children and adolescents. The role of these therapies on the pathogenesis and occurrence of migraine needs to be further elucidated because of the huge potential impact in terms of public health.

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Section: Discussioncontrasting

confidence: 90%

Association Between Migraine and Atopic Diseases in Childhood: A Potential Protective Role of Anti‐Allergic Drugs

et al. 2017

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“…Several studies have correlated allergic rhinitis with migraine in childhood, pointing either to a prominent prevalence of the latter in patients with atopy 10 , or to a higher than expected frequency of allergic conditions in migraineurs 5,7-9 . The susceptibility for developing migraine in children suffering from allergic rhinitis was also suggested 11,12 .…”

Section: Discussionmentioning

confidence: 99%

“…Although this relationship may be bidirectional, two longitudinal surveys from Taiwan have reported a higher risk of developing migraine in atopic children in comparison with nonatopic children, especially those with allergic rhinitis 11,12 , suggesting a role of the immune system in the manifestation of migraine. On the other hand, anti-asthmatic and anti-allergic therapies were associated with decreased risk of migraine in children and adolescents 8 .…”

mentioning

confidence: 99%

The influence of allergic rhinoconjunctivitis on migraine disability in children

Forcelini

Ramos

Santos

et al. 2019

Arq. Neuro-Psiquiatr.

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Migraine is a common condition in the pediatric population and causes a significant impact on the quality of life. Atopic disorders are some of the migraine comorbidities. Objective We hypothesized that allergic rhinitis could aggravate migraine in the pediatric population. Methods This cross-sectional study consecutively evaluated 90 pediatric outpatients (46 children 6–12 years of age; 44 adolescents up to 18 years of age) who sought medical assistance because of migraine at a general neurology clinic in Passo Fundo, RS, Brazil. They, and their parents, were given three questionnaires, to evaluate the diagnosis of current allergic rhinitis, allergic rhinoconjunctivitis and seasonal allergic rhinitis, as well as the disability caused by headache (ISAAC - International Study of Asthma and Allergies in Childhood; CARATkids - Control of Allergic Rhinitis and Asthma Test for Children; PedMIDAS - Pediatric Migraine Disability Assessment). The study was approved by the local ethics committee. Results According to the ISAAC questionnaire, children with current allergic rhinoconjunctivitis in the last year showed higher scores on the PedMIDAS than those patients without atopy (median and interquartile range 26 [10–58] vs. 5 [1–13], p = 0.008). A significant positive correlation of CARATkids scores with PedMIDAS scores was found (p = 0.007, rho = 0.39). After including other putative predictors of migraine disability (age, body mass index, time since onset of migraine) in a multiple regression analysis, only the scores on the CARATkids remained a significant independent variable correlated with PedMIDAS scores (p = 0.001; R = 0.55; R2 = 0.30). Conclusions Current allergic rhinoconjunctivitis is related to enhanced disability caused by headache in childhood migraine.

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“…Finally, the present research only included adults. Children with allergic rhinitis have been found to have a higher incidence and subsequent risk of migraine 30 . The results from our exploratory investigation in adult migraine patients do not exclude the possibility of a major relationship in the pediatric population, which is not affected by the senility of the immune system, or the influence of sex hormones observed in adults, especially women.…”

Section: Discussionmentioning

confidence: 99%

Is allergic rhinitis related to migraine disability in adults?

Forcelini

Gradaschi

Tonin

et al. 2019

Arq. Neuro-Psiquiatr.

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Migraine is a chronic condition with complex pathophysiology. Although immunologic disturbances have been linked to migraine, only few attempts have been made to assess the possibility of allergic rhinitis as a worsening factor of migraine in adults. Objective This survey aimed to compare migraine disability between adult migraineurs with and without current allergic rhinitis. Methods This cross-sectional study comprised 118 adult migraineurs who were consecutively assisted at an outpatient clinic. After ordinary neurological evaluation, participants were evaluated for headache disability using the Migraine Disability Assessment (MIDAS). The presence of current allergic rhinitis, allergic rhinoconjunctivitis and seasonal allergic rhinitis was scored for each participant according to the International Study of Asthma and Allergies in questionnaire. Results There was no significant difference between the MIDAS scores of those with current allergic rhinitis, allergic rhinoconjunctivitis, or seasonal allergic rhinitis and nonatopic migraineurs. The disability caused by allergic symptoms also did not influence the MIDAS scores of patients with allergic rhinitis. The frequency of headache days during the last three months was higher in the subset of patients without allergic rhinitis (median and interquartile range 12 [8–19.2] vs. 8 [4–14]; p = 0.03). Conclusions Our results suggest that current allergic rhinitis, allergic rhinoconjunctivitis, and seasonal allergic rhinitis are not related to headache disability in adults with episodic migraine.

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Allergic rhinitis and associated risk of migraine among children: a nationwide population‐based cohort study

Abstract: Children with AR had a higher incidence and subsequent risk of migraine. Physicians should be more aware of migraine in children with AR who complain of headache.

Cited by 18 publications

References 44 publications

Association Between Migraine and Atopic Diseases in Childhood: A Potential Protective Role of Anti‐Allergic Drugs

Association Between Migraine and Atopic Diseases in Childhood: A Potential Protective Role of Anti‐Allergic Drugs

The influence of allergic rhinoconjunctivitis on migraine disability in children

Is allergic rhinitis related to migraine disability in adults?

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