Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet, Jean; Khaltaev, Nikolaï; Cruz, Álvaro Augusto; Denburg, Judah A.; Fokkens, Wytske J.; Togias, Alkis; Zuberbier, Torsten; Baena-Cagnani, Carlos E.; Canonica, Giorgio Walter; Weel, Chris van; Agache, Ioana; Aït-Khaled, N; Bachert, Claus; Blaiss, Michael S.; Бонини, С.; Boulet, L.P.; Bousquet, Philippe; Camargos, Paulo Augusto Moreira; Carlsen, Kai‐Håkon; Chen, Y.; Čustović, Adnan; Dahl, Ronald; Demoly, Pascal; Douagui, H.; Durham, Stephen R.; Wijk, Roy Gerth van; Kalaycı, Ömer; Kaliner, Michael; Kim, Y.-Y.; Kowalski, Marek L.; Kuna, Piotr; Le, L. T. T.; Lemière, Catherine; Li, J.; Lockey, Richard F.; Mavale‐Manuel, S.; Meltzer, Eli O.; Mohammad, Yousser; Mullol, Joaquim; Naclerio, Robert; O’Hehir, Robin; Ohta, Ken; Ouedraogo, S.; Palkonen, Susanna; Papadopoulos, Nikolaos G.; Passalacqua, Giovanni; Pawankar, Ruby; Popov, Todor A.; Rabe, Klaus F.; Rosado‐Pinto, J.; Scadding, Glenis K.; Simons, F. Estelle R.; Toskala, Elina; Valovirta, Erkka; Cauwenberge, Paul Van; Wang, D.-Y.; Wickman, Magnus; Yawn, Barbara P.; Yorgancıoğlu, Arzu; Yusuf, Osman; Zar, Heather J.; Annesi‐Maesano, Isabella; Bateman, Eric D.; Kheder, A. Ben; Boakye, Daniel; Bouchard, Jacques; Burney, Peter; Busse, William W.; Chan‐Yeung, Moira; Chavannes, Niels H.; Chuchalin, Alexander; Dolen, William K.; Ėmužytė, Regina; Grouse, L.; Humbert, Marc; Jackson, Cathy; Johnston, Sebastian L.; Keith, Paul K.; Kemp, James P.; Klossek, J.-M.; Larenas‐Linnemann, Désirée; Lipworth, Brian J.; Malo, Jean‐Luc; Marshall, Gailen D.; Naspitz, Charles K.; Nékám, K; Niggemann, B.; Niżankowska‐Mogilnicka, Ewa; Okamoto, Yoshitaka; Orrù, Marco; Potter, Paul; Price, David; Stoloff, Stuart W.; Vandenplas, Olivier; Viegi, Giovanni; Williams, Dennis; Renseigné, Non

doi:10.1111/j.1398-9995.2007.01620.x

Cited by 3,859 publications

(1,879 citation statements)

References 2,033 publications

(1,708 reference statements)

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“…Non-atopic asthma without rhinosinusitis may be a pre-requisite factor for the development of FAO in our patient cohort, because atopic asthma is usually milder, has an earlier onset and is more commonly accompanied by other allergic disease such as allergic rhinosinusitis [1,31,32]. Classification of severe asthma into several groups through cluster analysis also found that one cluster was characterized by childhood onset, more atopic and presence of RAO, while the other cluster consisted of patients with later-onset disease, less atopic and FAO[4].…”

Section: Discussionmentioning

confidence: 99%

Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study

Lee

Bae

et al. 2011

Respir Res

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BackgroundThe clinical manifestations of severe asthma are heterogeneous. Some individuals with severe asthma develop irreversible fixed airway obstruction, which is associated with poor outcomes. We therefore investigated the factors associated with fixed airway obstruction in Korean patients with severe asthma.MethodsSevere asthma patients from a Korean adult asthma cohort were divided into two groups according to the results of serial pulmonary function tests. One group had fixed airway obstruction (FAO) [forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio < 0.7, n = 119] and the other had reversible airway obstruction (RAO) [FEV1/FVC ratio ≥ 0.7, n = 116]. Clinical and demographic parameters were compared between the two groups.ResultsMultivariate analysis showed that longer duration of disease, greater amount of cigarette smoking and absence of rhinosinusitis were significantly related to the development of FAO in severe asthmatics. Other parameters, including atopic status, pattern of airway inflammatory cells in induced sputum, and frequency of asthma exacerbations did not differ between the FAO and RAO groups.ConclusionSevere asthma patients with longer disease duration and the absence of rhinosinusitis are more likely to develop FAO. This study also demonstrates the importance of quitting smoking in order to prevent irreversible airway obstruction. Further investigation is required to determine the mechanism by which these factors can modify the disease course in Korean patients with severe asthma.

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Section: Discussionmentioning

confidence: 99%

Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study

Lee

Bae

et al. 2011

Respir Res

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“…Patients with allergic rhinitis and severe asthma are treated with antihistamines, nasal steroids, saline irrigation and specific allergen immunotherapy [135]. Furthermore, anti-leukotrienes may target both upper and lower airways [135,136].…”

Section: Management Of Severe Asthmamentioning

confidence: 99%

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Porsbjerg

Ulrik

Skjold

et al. 2018

European Clinical Respiratory Journal

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Although a minority of asthma patients suffer from severe asthma, they represent a major clinical challenge in terms of poor symptom control despite high-dose treatment, risk of exacerbations, and side effects. Novel biological treatments may benefit patients with severe asthma, but are expensive, and are only effective in appropriately targeted patients. In some patients, symptoms are driven by other factors than asthma, and all patients with suspected severe asthma (‘difficult asthma’) should undergo systematic assessment, in order to differentiate between true severe asthma, and ‘difficult-to-treat’ patients, in whom poor control is related to factors such as poor adherence or co-morbidities. The Nordic Consensus Statement on severe asthma was developed by the Nordic Severe Asthma Network, consisting of members from Norway, Sweden, Finland, Denmark, Iceland and Estonia, including representatives from the respective national respiratory scientific societies with the aim to provide an overview and recommendations regarding the diagnosis, systematic assessment and management of severe asthma. Furthermore, the Consensus Statement proposes recommendations for the organization of severe asthma management in primary, secondary, and tertiary care.

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“…Second generation AHs are usually effective against sneezing and rhinorrhea through H 1 receptor blockade but are less effective against nasal congestion, which is induced by mediators other than histamine5,24. LCTZ is a potent anti-allergic drug, classified as a second-generation antihistamine, with an early onset of action and a long duration of effects on the symptoms of AR25.…”

Section: Discussionmentioning

confidence: 99%

“…The former exert a rapid reduction in early-phase AR symptoms, such as sneezing, rhinorrhea, and nasal itching, through their effects on histamine5, while the latter have inhibitory effects mainly on late-phase AR reactions through the reduction of inflammatory cell recruitment and inflammatory mediator release33. Therefore, a combination therapy involving both an AH and an INS might have combined effects on allergen-induced symptoms and seems to be of clinical benefit.…”

Section: Discussionmentioning

confidence: 99%

“…According to the ARIA guidelines5, a second-generation H1-anti-histamine (AH) is recommended as the first line therapy in patients with mild-to-moderate symptoms, while intra-nasal corticosteroids (INSs) are recommended for patients with moderate-to-severe symptoms5. If such a treatment does not have a satisfactory effect, combination therapy with an AH or a leukotriene receptor antagonist (LTRA) is possible.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber

Hashiguchi

Kanzaki

Wakabayashi

et al. 2013

Journal of Drug Assessment

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ObjectiveThis study investigated the clinical efficacy of a combination therapy of levocetirizine (LCTZ) and fluticasone furoate nasal spray (FFNS), compared with LCTZ monotherapy, for the suppression of seasonal allergic rhinitis (SAR) symptoms induced in an artificial exposure chamber.MethodsThis study was a single-center, placebo-controlled, randomized, 3-way cross-over comparative study performed in 42 Japanese cedar pollinosis patients. These subjects received (1) LCTZ plus FFNS (combination group), (2) LCTZ plus FFNS placebo (monotherapy group), or (3) LCTZ placebo plus FFNS placebo (placebo group) once on the night prior to exposure, with a 1-week washout period between exposures. Nasal (sneezing, rhinorrhea, nasal congestion, and itchy nose) and ocular (eye itching and tearing) symptoms were recorded every 15 min, and the number of sneezes, nose blowing events, and the amount of nasal secretions were measured during exposure. The primary end-point was the cumulative incidence of SAR symptoms during exposure and the ‘ime to occurrence of symptoms’. The secondary end-points were the total nasal symptom score, the ocular symptom score, the amount of nasal discharge, and the number of sneezes and nose blowing events.ResultsAt all the measurement points, the lowest cumulative incidences for the nasal symptoms were observed in the combination group, followed by the monotherapy and placebo groups. All the subjects in the placebo group developed nasal symptoms within 2 h after pollen exposure, while three and eight subjects in the monotherapy and combination groups, respectively, did not develop any nasal symptoms during exposure. In addition, combination therapy delayed the onset of symptoms.ConclusionsThe results demonstrated that combination therapy with FFNS and LCTZ significantly suppressed the induced SAR symptoms and delayed the onset of symptoms compared with LCTZ monotherapy and placebo. Although the conditions of the allergen challenge study using an exposure chamber are different from those in real life, combination therapy with FF and LCTZ was confirmed to be an effective treatment for SAR.

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Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Cited by 3,859 publications

References 2,033 publications

Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study

Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber

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