Research efforts in allergic rhinitis have always been intense. Over the past 3 years, numerous breakthroughs in basic science and clinical research have been made, augmenting our understanding of this condition that afflicts a significant proportion of the global population. New epidemiological findings, novel insights into the molecular and cellular mechanisms of allergy, enhancement of current developmental theories, new concepts of the goals and endpoints of management, and latest therapeutic modalities that includes the harnessing of information technology and big data are some areas where important advances were made. We attempt to bring you a summary of the key research advances made in the field of allergic rhinitis from 2013 to 2015.Allergic rhinitis (AR) is a common condition that affects a significant proportion of the global population, across all age groups, and is often a life-long condition. Its impact on direct and indirect healthcare costs is significant and it negatively impacts patients' quality of life, work performance and social functioning (1). Overall, AR poses a significant public health burden. Research efforts on AR have been intensive given its significance. Busy clinicians and scientists may find it difficult to keep up with the plethora of published articles and sift out the salient points. We performed this review of articles published mainly in Allergy (2013Allergy ( -2015, a representative journal in the field, to provide an update on important research findings on AR.Interesting research findings on the epidemiology, developmental theories and pathophysiology, novel technology and management have emerged. However, these studies are of diverse and unique content. We grouped these studies into a coherent bundle, which might aid in contextual understanding and interpretation. Areas of debate and uncertainty are discussed for potential research to be considered for the clarification of these knowledge gaps.
Prevalence, burden and comorbidities of AR
Preschool children: a neglected populationThe international ISAAC studies have elucidated the prevalence of AR, AD and asthma in children above the age of six and have enhanced our understanding of allergy in paediatric populations (2, 3). Data in preschool children are, however, lacking. A nationwide study in Portugal found that 43.4% of preschool children had rhinitis based on an adapted ISAAC questionnaire (4). A Brazilian study used Phase III EISL and modified ISAAC questionnaires to assess rhinitis symptoms in infants aged 12-15 months. This study found that 48.3% of children had at least one episode of sneezing, runny or blocked nose without cold or flu in the first year of life, and a quarter of infants had recurrent wheezing (≥3 episodes) and wheezing was more frequent in the presence of AR symptoms (5). A higher prevalence in preschool children may be expected as infectious rhinitis or other types of rhinitis is common due to a wide spectrum of risk factors (e.g. viruses, bacteria, moulds and other stimAllergy 70 (2015) ...